Search Results - "Schneider, MR"

IGF-binding protein-5: flexible player in the IGF system and effector on its own by Schneider, MR, Wolf, E, Hoeflich, A, Lahm, H

“…The multiple activities of IGF-I and -II are modulated by a family of IGF-binding proteins (IGFBP-1 to -6). Although structurally related, each IGFBP has…”
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Prostacyclin and its analogues: antimetastatic effects and mechanisms of action by Schneider, M R, Tang, D G, Schirner, M, Honn, K V

“…More than a decade ago, prostacyclin, a dienoic bicyclic eicosanoid derived from the metabolism of arachidnoic acid, was found to possess potent inhibitory…”
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Insulin-like growth factor-binding protein-4 inhibits growth of the thymus in transgenic mice by Zhou, R, Flaswinkel, H, Schneider, MR, Lahm, H, Hoeflich, A, Wanke, R, Wolf, E

“…Numerous in vitro studies have demonstrated that IGF-binding protein (IGFBP)-4 is a consistent inhibitor of IGF actions. In order to investigate the functions…”
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PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration by WOOD, J. M, BOLD, G, PERSOHN, E, RÖSEL, J, SCHNELL, C, STOVER, D, THEUER, A, TOWBIN, H, WENGER, F, WOODS-COOK, K, MENRAD, A, SIEMEISTER, G, BUCHDUNGER, E, SCHIRNER, M, THIERAUCH, K.-H, SCHNEIDER, M. R, DREVS, J, MARTINY-BARON, G, TOTZKE, F, MARME, D, COZENS, R, FERRARI, S, FREI, J, HOFMANN, F, MESTAN, J, METT, H, O'REILLY, T

“…PTK787/ZK 222584 (1-[4-chloroanilino]-4-[4-pyridylmethyl] phthalazine succinate) is a potent inhibitor of vascular endothelial growth factor (VEGF) receptor…”
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Switch from antagonist to agonist of the androgen receptor blocker bicalutamide is associated with prostate tumour progression in a new model system by CULIG, Z, HOFFMANN, J, KLOCKER, H, ERDEL, M, EDER, I. E, HOBISCH, A, HITTMAIR, A, BARTSCH, G, UTERMANN, G, SCHNEIDER, M. R, PARCZYK, K

“…Advanced prostate cancer is treated by androgen ablation and/or androgen receptor (AR) antagonists. In order to investigate the mechanisms relevant to the…”
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Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors by LICHTNER, Rosemarie B, MENRAD, Andreas, SOMMER, Anette, KLAR, Ulrich, SCHNEIDER, Martin R

“…Several inhibitors of EGF receptor (EGFR) tyrosine kinase activity have been developed that compete with ATP at its binding site such as the quinazolines PD…”
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Betacellulin Overexpression in Transgenic Mice Causes Disproportionate Growth, Pulmonary Hemorrhage Syndrome, and Complex Eye Pathology by Schneider, Marlon R, Dahlhoff, Maik, Herbach, Nadja, Renner-Mueller, Ingrid, Dalke, Claudia, Puk, Oliver, Graw, Jochen, Wanke, Rüdiger, Wolf, Eckhard

“…The EGF family comprises a network of ligands and receptors that regulate proper development and elicit diverse functions in physiology and pathology…”
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Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells by Schneider, Marlon R, Hoeflich, Andreas, Fischer, Jürgen R, Wolf, Eckhard, Sordat, Bernard, Lahm, Harald

“…Interleukin-6 (IL-6) is a pleiotropic cytokine which exerts biological activities on various cell types including neoplastic cells. We have investigated the…”
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Genotyping of transgenic mice: Old principles and recent developments by Schneider, Marlon R., Wolf, Eckhard

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Characterization of new estrogen receptor destabilizing compounds: Effects on estrogen-sensitive and tamoxifen-resistant breast cancer by HOFFMANN, Jens, BOHLMANN, Rolf, GIESCHEN, Hille, ULBRICH, Hannes-F, SCHNEIDER, Martin R, HEINRICH, Nikolaus, HOFMEISTER, Helmut, KROLL, Jörg, KÜNZER, Hermann, LICHTNER, Rosemarie B, NISHINO, Yuki, PARCZYK, Karsten, SAUER, Gerhard

“…Antiestrogens of the selective estrogen receptor modulator (SERM) type, such as tamoxifen, have two major limitations: their mixed agonist and antagonist…”
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Transgenic mouse models for studying the functions of insulin‐like growth factor‐binding proteins by Schneider, Marlon R., Lahm, Harald, Wu, Minyao, Hoeflich, Andreas, Wolf, Eckhard

“…The insulin‐like growth factor‐binding proteins (IGFBPs) comprise a family of six related peptides that interact with high affinity with IGFs. IGFBPs compete…”
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Comparison of Proteomic and Genomic Analyses of the Human Breast Cancer Cell Line T47D and the Antiestrogen-resistant Derivative T47D-r by Huber, Martina, Bahr, Inke, Krätzschmar, Jörn R, Becker, Andreas, Müller, Eva-Christina, Donner, Peter, Pohlenz, Hans-Dieter, Schneider, Martin R, Sommer, Anette

“…In search of novel mechanisms leading to the development of antiestrogen-resistance in human breast tumors, we analyzed differences in the gene and protein…”
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Photodynamic therapy for symptomatic circumscribed choroidal hemangioma by MAYER, CF, WACKERNAGEL, W, LACKNER, EM, SCHNEIDER, MR, HAAS, A, WEGER, M, LANGMANN, G

“…Purpose Photodynamic therapy (PDT) is a well established treatment option for symptomatic choroidal hemangioma. We present seven patients treated with PDT at…”
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Immunohistochemical findings and proliferation markers in uveal melanomas after gamma‐knife radiosurgery by WACKERNAGEL, W, MAYER, CF, LACKNER, EM, SCHNEIDER, MR, LANGMANN, G, UNGER, F, KLEINERT, R

“…Purpose We describe immunohistochemical characteristics and tumor cell proliferation in 12 eyes with uveal melanoma enucleated after Gamma‐Knife radiosurgery…”
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Antiangiogenic chemotherapeutic agents: characterization in comparison to their tumor growth inhibition in human renal cell carcinoma models by SCHIRNER, M, HOFFMANN, J, MENRAD, A, SCHNEIDER, M. R

“…The mechanism of action of anticancer chemotherapeutic agents is mainly thought to be due to a direct inhibition of tumor cell proliferation. The enhanced…”
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Insulin-like Growth Factor-Binding Protein-5 Inhibits Growth and Induces Differentiation of Mouse Osteosarcoma Cells by Schneider, Marlon R., Zhou, Rui, Hoeflich, Andreas, Krebs, Ottheinz, Schmidt, Jörg, Mohan, Subburaman, Wolf, Eckhard, Lahm, Harald

“…The precise role of insulin-like growth factor-binding protein-5 (IGFBP-5) in regulating the growth of tumor cells, especially of bone-derived malignant cells,…”
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A highly sensitive model for quantification of in vivo tumor angiogenesis induced by alginate-encapsulated tumor cells by HOFFMANN, J, SCHIRNER, M, MENRAD, A, SCHNEIDER, M. R

“…A remarkable approach to a specific tumor angiogenesis model in vivo is the use of alginate implants encapsulating tumor cells. However, this previously…”
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Studies on the development of resistance to the pure antiestrogen Faslodex™ in three human breast cancer cell lines by Sommer, Anette, Hoffmann, Jens, Lichtner, Rosemarie B., Schneider, Martin R., Parczyk, Karsten

“…In order to understand the mechanisms underlying the development of resistance to a pure antiestrogen we established three human breast carcinoma cell lines…”
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Functional consequences of IGFBP excess-lessons from transgenic mice by Wolf, Eckhard, Schneider, Marlon R, Zhou, Rui, Fisch, Thomas M, Herbach, Nadja, Dahlhoff, Maik, Wanke, Rüdiger, Hoeflich, Andreas

“…The functions of insulin-like growth factor-binding proteins (IGFBPs) have been studied extensively in vitro, revealing IGF-dependent and also IGF-independent…”
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Ring opening of phenylaziridines with allylsilanes by Schneider, Marie-Reine, Mann, André, Taddei, Maurizio

“…N-tosyl phenylaziridines are opened regioselectively with allylsilanes in presence of BF 3.Et 2O to form γ-amino olefins. During the reaction a formal [3+2]…”
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