Search Results - "Schneider, Ian C."

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells by Haage, Amanda, Schneider, Ian C.

“…The pathogenesis of cancer is often driven by local invasion and metastasis. Recently, mechanical properties of the tumor microenvironment have been identified…”
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Mechanical integration of actin and adhesion dynamics in cell migration by Gardel, Margaret L, Schneider, Ian C, Aratyn-Schaus, Yvonne, Waterman, Clare M

“…Directed cell migration is a physical process that requires dramatic changes in cell shape and adhesion to the extracellular matrix. For efficient movement,…”
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Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation by Pasapera, Ana M, Schneider, Ian C, Rericha, Erin, Schlaepfer, David D, Waterman, Clare M

“…Focal adhesions (FAs) are mechanosensitive adhesion and signaling complexes that grow and change composition in response to myosin II-mediated cytoskeletal…”
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Directed cell migration in multi-cue environments by Lara Rodriguez, Laura, Schneider, Ian C

“…Cell migration plays a critical role in development, angiogenesis, immune response, wound healing and cancer metastasis. During these processes, cells are…”
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Epidermal growth factor-induced contraction regulates paxillin phosphorylation to temporally separate traction generation from de-adhesion by Schneider, Ian C, Hays, Cristen K, Waterman, Clare M

“…Directed cell migration is mediated by cycles of protrusion, adhesion, traction generation on the extracellular matrix and retraction. However, how the events…”
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Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli by Lee, Ki Baek, Nam, Dong Hyun, Nuhn, Jacob A M, Wang, Juan, Schneider, Ian C, Ge, Xin

“…As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal…”
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Quantitative elucidation of a distinct spatial gradient-sensing mechanism in fibroblasts by Schneider, Ian C, Haugh, Jason M

“…Migration of eukaryotic cells toward a chemoattractant often relies on their ability to distinguish receptor-mediated signaling at different subcellular…”
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Mechanisms of Gradient Sensing and Chemotaxis: Conserved Pathways, Diverse Regulation by Schneider, Ian C., Haugh, Jason M.

“…Directed cell migration is critical for normal development, immune responses, and wound healing and plays a prominent role in tumor metastasis. In eukaryotes,…”
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Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery of Antigen and Improve Vaccine Efficacy while Inducing Low Inflammation by Senapati, Sujata, Darling, Ross J, Loh, Darren, Schneider, Ian C, Wannemuehler, Michael J, Narasimhan, Balaji, Mallapragada, Surya K

“…As the focus has shifted from traditional killed or live, attenuated vaccines toward subunit vaccines, improvements in vaccine safety have been confronted with…”
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Kinetic Analysis of Platelet-derived Growth Factor Receptor/Phosphoinositide 3-Kinase/Akt Signaling in Fibroblasts by Park, Chang Shin, Schneider, Ian C., Haugh, Jason M.

“…Isoforms of the serine-threonine kinase Akt coordinate multiple cell survival pathways in response to stimuli such as platelet-derived growth factor (PDGF)…”
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Myosin phosphorylation on stress fibers predicts contact guidance behavior across diverse breast cancer cells by Wang, Juan, Schneider, Ian C

“…Abstract During cancer progression the extracellular matrix is remodeled, forming aligned collagen fibers that proceed radially from the tumor, resulting in…”
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Cancer cell migration in collagen-hyaluronan composite extracellular matrices by Unnikandam Veettil, Shalini R., Hwang, Dohgyu, Correia, Jacinta, Bartlett, Michael D., Schneider, Ian C.

“…Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness. While the molecular weight (MW)…”
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Matrix metalloproteinase-14 is a mechanically regulated activator of secreted MMPs and invasion by Haage, Amanda, Nam, Dong Hyun, Ge, Xin, Schneider, Ian C.

“…•MMP-14 function blocking mAbs are 10-fold more potent than pan MMP-inhibitors.•MMP-14 activates soluble MMPs in response to mechanical stimuli.•MMP-14 unction…”
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Contact guidance diversity in rotationally aligned collagen matrices by Nuhn, Jacob A.M., Perez, Anai M., Schneider, Ian C.

“…[Display omitted] Cancer cell metastasis is responsible for approximately 90% of deaths related to cancer. The migration of cancer cells away from the primary…”
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Tubulin CFEOM mutations both inhibit or activate kinesin motor activity by Luchniak, Anna, Roy, Pallavi Sinha, Kumar, Ambuj, Schneider, Ian C, Gelfand, Vladimir I, Jernigan, Robert L, Gupta, Jr, Mohan L

“…Kinesin-mediated transport along microtubules is critical for axon development and health. Mutations in the kinesin Kif21a, or the microtubule subunit…”
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Epitaxially Grown Collagen Fibrils Reveal Diversity in Contact Guidance Behavior among Cancer Cells by Wang, Juan, Petefish, Joseph W., Hillier, Andrew C., Schneider, Ian C.

“…Invasion of cancer cells into the surrounding tissue is an important step during cancer progression and is driven by cell migration. Cell migration can be…”
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Microtissue size and cell-cell communication modulate cell migration in arrayed 3D collagen gels by Nuhn, Jacob A. M., Gong, Shenmin, Che, Xiangchen, Que, Long, Schneider, Ian C.

“…Cells communicate through the extracellular matrix (ECM) in many physiological and pathological processes. This is particularly important during cell…”
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Tuning surface functionalization and collagen gel thickness to regulate cancer cell migration by Unnikandam Veettil, Shalini R., Van Bruggen, Shawn M., Hwang, Doh-Gyu, Bartlett, Michael D., Schneider, Ian C.

“…[Display omitted] •3D collagen gel size and attachment to stiff interfaces alter cancer cell biology.•Attachment increases cell area close to interfaces, but…”
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Transfer of assembled collagen fibrils to flexible substrates for mechanically tunable contact guidance cues by Wang, Juan, Koelbl, Joseph, Boddupalli, Anuraag, Yao, Zhiqi, Bratlie, Kaitlin M, Schneider, Ian C

“…Contact guidance or bidirectional migration along aligned fibers modulates many physiological and pathological processes such as wound healing and cancer…”
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Correction to: Microtissue size and cell-cell communication modulate cell migration in arrayed 3D collagen gels by Nuhn, Jacob A. M., Gong, Shenmin, Che, Xiangchen, Que, Long, Schneider, Ian C.

“…The original version of this article unfortunately contained a mistake. One line indicating statistical significance was improperly placed in Fig. 5…”
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