Search Results - "Schneider, Anneliese"

Dissecting the mechanism of cytokine release induced by T-cell engagers highlights the contribution of neutrophils by Leclercq, Gabrielle, Servera, Llucia Alberti, Danilin, Sabrina, Challier, John, Steinhoff, Nathalie, Bossen, Claudia, Odermatt, Alex, Nicolini, Valeria, Umaña, Pablo, Klein, Christian, Bacac, Marina, Giusti, Anna-Maria, Schneider, Anneliese, Haegel, Hélène

“…T cell engagers represent a novel promising class of cancer-immunotherapies redirecting T cells to tumor cells and have some promising outcomes in the clinic…”
Get full text

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies by Kerns, S Jordan, Belgur, Chaitra, Petropolis, Debora, Kanellias, Marianne, Barrile, Riccardo, Sam, Johannes, Weinzierl, Tina, Fauti, Tanja, Freimoser-Grundschober, Anne, Eckmann, Jan, Hage, Carina, Geiger, Martina, Ng, Patrick Ray, Tien-Street, William, Manatakis, Dimitris V, Micallef, Virginie, Gerard, Regine, Bscheider, Michael, Breous-Nystrom, Ekaterina, Schneider, Anneliese, Giusti, Anna Maria, Bertinetti-Lapatki, Cristina, Grant, Heather Shannon, Roth, Adrian B, Hamilton, Geraldine A, Singer, Thomas, Karalis, Katia, Moisan, Annie, Bruenker, Peter, Klein, Christian, Bacac, Marina, Gjorevski, Nikolce, Cabon, Lauriane

“…Traditional drug safety assessment often fails to predict complications in humans, especially when the drug targets the immune system. Here, we show the…”
Get full text

Transforming growth factor‐beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer by Schlingensiepen, Karl‐Hermann, Jaschinski, Frank, Lang, Sven Arke, Moser, Christian, Geissler, Edward Kenneth, Schlitt, Hans Jürgen, Kielmanowicz, Marcus, Schneider, Anneliese

“…Pancreatic cancer is one of the most aggressive human cancers with a 5‐year survival rate of <5%. Overexpression of transforming growth factor‐beta 2 (TGF‐β2)…”
Get full text

Quantification of oligonucleotides by LC-MS/MS: the challenges of quantifying a phosphorothioate oligonucleotide and multiple metabolites by Ewles, Matthew, Goodwin, Lee, Schneider, Anneliese, Rothhammer-Hampl, Tanja

“…LC-MS/MS allows quantification of therapeutic oligonucleotides in biological fluids at low ng/ml concentrations. Achieving selectivity between metabolites and…”
Get full text

JAK and mTOR inhibitors prevent cytokine release while retaining T cell bispecific antibody in vivo efficacy by Leclercq, Gabrielle, Haegel, Hélène, Toso, Alberto, Zimmermann, Tina, Green, Luke, Steinhoff, Nathalie, Sam, Johannes, Pulko, Vesna, Schneider, Anneliese, Giusti, Anna Maria, Challier, John, Freimoser-Grundschober, Anne, Larivière, Laurent, Odermatt, Alex, Stern, Martin, Umana, Pablo, Bacac, Marina, Klein, Christian

“…BackgroundT cell engaging therapies, like chimeric antigen receptor T cells and T cell bispecific antibodies (TCBs), efficiently redirect T cells towards tumor…”
Get full text

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies by Leclercq, Gabrielle, Haegel, Hélène, Schneider, Anneliese, Giusti, Anna Maria, Marrer-Berger, Estelle, Boetsch, Christophe, Walz, Antje-Christine, Pulko, Vesna, Sam, Johannes, Challier, John, Ferlini, Cristiano, Odermatt, Alex, Umaña, Pablo, Bacac, Marina, Klein, Christian

“…BackgroundT cell engagers are bispecific antibodies recognizing, with one moiety, the CD3ε chain of the T cell receptor and, with the other moiety, specific…”
Get full text

Human immunocompetent choroid-on-chip: a novel tool for studying ocular effects of biological drugs by Cipriano, Madalena, Schlünder, Katharina, Probst, Christopher, Linke, Kirstin, Weiss, Martin, Fischer, Mona Julia, Mesch, Lena, Achberger, Kevin, Liebau, Stefan, Mesquida, Marina, Nicolini, Valeria, Schneider, Anneliese, Giusti, Anna Maria, Kustermann, Stefan, Loskill, Peter

“…Disorders of the eye leading to visual impairment are a major issue that affects millions of people. On the other side ocular toxicities were described for…”
Get full text

The antisense oligonucleotide trabedersen (AP 12009) for the targeted inhibition of TGF-β2 by Jaschinski, Frank, Rothhammer, Tanja, Jachimczak, Piotr, Seitz, Christian, Schneider, Anneliese, Schlingensiepen, Karl-Hermann

“…Despite remarkable advances in cancer research, patients with malignant tumors such as high-grade glioma or advanced pancreatic carcinoma still face a poor…”
Get more information

Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids by Harter, Marius F., Recaldin, Timothy, Gerard, Regine, Avignon, Blandine, Bollen, Yannik, Esposito, Cinzia, Guja-Jarosz, Karolina, Kromer, Kristina, Filip, Adrian, Aubert, Julien, Schneider, Anneliese, Bacac, Marina, Bscheider, Michael, Stokar-Regenscheit, Nadine, Piscuoglio, Salvatore, Beumer, Joep, Gjorevski, Nikolche

“…Predicting the toxicity of cancer immunotherapies preclinically is challenging because models of tumours and healthy organs do not typically fully recapitulate…”
Get full text

Abstract 2961: HLA-G-TCB (RG6353), a T cell bispecific antibody for the treatment of solid tumors in monotherapy and combination with immunomodulator agents by Majety, Meher, Hage, Carina, Bujotzek, Alexander, Schneider, Anneliese, Lechmann, Martin, Nair, Nitya, Zimmerman, Stefan, Morel, Anthony, Klein, Christian, Umana, Pablo

“…Abstract T-cell bispecific antibodies (TCB) represent a class of therapeutic agents that specifically activate T cells to attack and kill tumor cells. TCBs…”
Get full text

Abstract 1235: Impact of anti-CD3 and tumor-target binder affinities on in-vitro potency, in-vivo efficacy, and cytokine release by Abdelmotaleb, Omar, Schneider, Anneliese, Hofer, Thomas, Sam, Johannes, Lechmann, Martin, Waldhauer, Inja, Bransi, Ali, Eigenmann, Miro, Freimoser-Grundschober, Anne, Gassner, Christian, Odermatt, Alex, Brünker, Peter, Colombetti, Sara, Klein, Christian

“…Abstract Background: First generation T cell bispecifics (TCBs) were developed by utilizing high CD3 and tumor target binder affinities to induce a potent…”
Get full text

Abstract 1979: Dissecting the cellular and molecular players of T Cell Bispecific (TCB) antibody-mediated CRS by Leclercq, Gabrielle, Steinhoff, Nathalie, Alberti-Serverra, LLucia, Yángüez, Emilio, Nassiri, Sina, Giusti, Anna-Maria, Schneider, Anneliese, Klein, Christian, Haegel, Hélène, Umaña, Pablo, Sam, Johannes, Bacac, Marina

“…Abstract T-cell bispecific antibodies (TCBs) are a promising class of immunotherapies that activate T cells by engaging the CD3ε chain of the T-cell receptor…”
Get full text

653 Dasatinib as a rapid pharmacological ON/OFF switch for T cell bispecific antibody-induced T cell activation and cytokine release by Leclercq, Gabrielle, Haegel, Helene, Schneider, Anneliese, Berger, Estelle Marrer, Walz, Antje, Boetsch, Christophe, Pulko, Vesna, Ferlini, Cristiano, Klein, Christian

“…BackgroundT cell bispecific antibodies (TCBs) are extremely potent T cell engagers, harboring a 2+1 format with one binder to the CD3ε chain and two binders to…”
Get full text

Abstract 2362: Targeted suppression of TGF-beta2 by trabedersen (AP 12009) in an orthotopic xenograft melanoma mouse model by Rothhammer-Hampl, Tanja, Jaschinski, Frank, Bäuerlein, Veronika, Haarstrich, Carina, Heinrichs, Hubert, Schneider, Anneliese

“…Abstract Background: TGF-β2 is a mediator of carcinogenesis by regulating key mechanisms such as cell proliferation, metastasis, and immunosuppression. The…”
Get full text

Small, Potent, and Selective Diaryl Phosphonate Inhibitors for Urokinase-Type Plasminogen Activator with In Vivo Antimetastatic Properties by Joossens, Jurgen, Ali, Omar M, El-Sayed, Ibrahim, Surpateanu, Georgiana, Van der Veken, Pieter, Lambeir, Anne-Marie, Setyono-Han, Buddy, Foekens, John A, Schneider, Anneliese, Schmalix, Wolfgang, Haemers, Achiel, Augustyns, Koen

“…A set of small nonpeptidic diaryl phosphonate inhibitors was prepared. Some of these inhibitors show potent and highly selective irreversible uPA inhibition…”
Get full text

Inducing anti-tumor cytokines and an immune response in melanoma by inhibition of MIA using the peptide AR71 by RIECHERS, Alexander, SCHMIDT, Jennifer, DETTMER, Katja, OEFNER, Peter, JACHIMCZAK, Piotr, SCHNEIDER, Anneliese, BOSSERHOFF, Anja-Katrin

“…Malignant melanoma is known for its aggressive metastatic spread and suppression of the host immune system. Immunosuppression in melanoma is mediated in part…”
Get full text

Functional observation battery in nonhuman primates with continuous intracerebral infusion by Authier, Simon, Bienvenu, Jean-Guy, Tavcar, Robert, Fournier, Sebastien, Schneider, Anneliese, Wong, Karen

Get full text

Final results of a phase I/II study in patients with pancreatic cancer, malignant melanoma, and colorectal carcinoma with trabedersen by Oettle, Helmut, Seufferlein, Thomas, Luger, Thomas, Schmid, Roland M., von Wichert, Goetz, Endlicher, Esther, Garbe, Claus, Kaehler, Katharina K., Enk, Alexander, Schneider, Anneliese, Rothhammer-Hampl, Tanja, Grosser, Susanne, Kiessling, Peter

“…Abstract only 4034 Background: TGF-β2 overexpression in solid tumors triggers key cancer pathomechanisms, i.e. suppression of antitumor immune responses system…”
Get full text

Stable Expression of Human Cytochrome P450 1B1 in V79 Chinese Hamster Cells and Metabolically Catalyzed DNA Adduct Formation of Dibenzo[a,l]pyrene by Luch, Andreas, Coffing, Stephanie L, Tang, Yong M, Schneider, Anneliese, Soballa, Volker, Greim, Helmut, Jefcoate, Colin R, Seidel, Albrecht, Greenlee, William F, Baird, William M, Doehmer, Johannes

“…Chinese hamster V79 cell lines were constructed for stable expression of human cytochrome P450 1B1 (P450 1B1) in order to study its role in the metabolic…”
Get full text

Stable Expression of Human Cytochrome P450 3A4 in Conjunction with Human NADPH-Cytochrome P450 Oxidoreductase in V79 Chinese Hamster Cells by Schneider, Anneliese, Schmalix, Wolfgang A., Siruguri, Vasanthi, de Groene, Els M., Horbach, G.Jean, Kleingeist, Britta, Lang, Dieter, Böcker, Ronald, Belloc, Claire, Beaune, Philippe, Greim, Helmut, Doehmer, Johannes

“…V79 Chinese hamster cells were constructed for stable expression of human cytochrome P450 3A4 with and without coexpression of human NADPH-cytochrome P450…”
Get full text