Search Results - "Schnebli, H"

Chelator‐induced iron excretion in iron‐overloaded marmosets by Sergejew, Thomas, Forgiarini, Peter, Schnebli, Hans‐Peter

“…In order to test new orally active iron chelators in a predictive way, a primate model has been developed. This model makes use of the marmoset monkey…”
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Anti-neutrophil elastase defense of the normal human respiratory epithelial surface provided by the secretory leukoprotease inhibitor by VOGELMEIER, C, HUBBARD, R. C, FELLS, G. A, SCHNEBLI, H.-P, THOMPSON, R. C, FRITZ, H, CRYSTAL, R. G

“…Secretory leukoprotease inhibitor (SLPI), a 12-kD nonglycosylated serine antiprotease with a high capacity for inhibiting neutrophil elastase (NE), is produced…”
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Aerosolization of recombinant SLPI to augment antineutrophil elastase protection of pulmonary epithelium by Vogelmeier, C, Buhl, R, Hoyt, R F, Wilson, E, Fells, G A, Hubbard, R C, Schnebli, H P, Thompson, R C, Crystal, R G

“…In a variety of lung diseases the respiratory epithelial surface must contend with an increased burden of neutrophil elastase (NE). One candidate for…”
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Crystal and molecular structure of the bovine alpha-chymotrypsin-eglin c complex at 2.0 A resolution by Frigerio, F, Coda, A, Pugliese, L, Lionetti, C, Menegatti, E, Amiconi, G, Schnebli, H P, Ascenzi, P, Bolognesi, M

“…The crystal structure of the complex between bovine alpha-chymotrypsin and the leech (Hirudo medicinalis) protein proteinase inhibitor eglin c has been refined…”
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Toxicity of oral iron chelator L1 by Berdoukas, V, Bentley, P, Frost, H, Schnebli, H P

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Crystal and molecular structure of the inhibitor eglin from leeches in complex with subtilisin Carlsberg by McPhalen, C.A., Schnebli, H.P., James, M.N.G.

“…The crystal structure of the molecular complex of eglin, a serine proteinase inhibitor from leeches, with subtilisin Carlsberg has been determined at 2.0 Å…”
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Fibronectin-Cleaving Activity in Bronchial Secretions of Patients with Cystic Fibrosis by Suter, Susanne, Schaad, U. B., Morgenthaler, J. J., Chevallier, I., Schnebli, H. P.

“…In cystic fibrosis, colonization of the airways with Pseudomonas aeruginosa follows colonization with Staphylococcus aureus and is related to accelerated…”
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Free radicals inactivate human neutrophil elastase and its inhibitors with comparable efficiency by Dean, R T, Nick, H P, Schnebli, H P

“…Free radicals produced in a Fenton reaction (H202/Cu), modelling some xenobiotic and cell-mediated inflammatory affronts, efficiently inactivated the…”
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Structure of the proteinase inhibitor eglin c with hydrolysed reactive centre at 2.0 Å resolution by Betzel, Christian, Dauter, Zbigniew, Genov, Nicolay, Lamzin, Victor, Navaza, Jorge, Schnebli, Hans Peter, Visan, Marcia, Wilson, Keith S.

“…The inhibition of serine proteinases by both synthetic and natural inhibitors has been widely studied. Eglin c is a small thermostable protein isolated from…”
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Future of oral iron chelator deferiprone (L1) by Mehta, J, Singhal, S, Mehta, B C

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Control of exogenous proteinases and their inhibitors at the macrophage cell surface by Dean, R T, Schnebli, H P

“…The actions and availability of human neutrophil elastase and its protein inhibitor, Eglin, when co-incubated with macrophages were investigated. Eglin did not…”
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Different susceptibility of elastase inhibitors to inactivation by proteinases from Staphylococcus aureus and Pseudomonas aeruginosa by Sponer, M, Nick, H P, Schnebli, H P

“…Neutrophil elastase is thought to contribute to the lung pathology in patients with cystic fibrosis (CF). Therefore, intrapulmonary application of elastase…”
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Recombinant elastase inhibitors for therapy by Schnebli, H P

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Binding of the recombinant proteinase inhibitor eglin c from leech Hirudo medicinalis to serine (pro)enzymes: a comparative thermodynamic study by Ascenzi, P, Aducci, P, Amiconi, G, Ballio, A, Guaragna, A, Menegatti, E, Schnebli, H P, Bolognesi, M

“…The binding of the recombinant proteinase inhibitor eglin c from the leech Hirudo medicinalis to serine (pro)enzymes belonging to the chymotrypsin and…”
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Future of oral iron chelator deferiprone (L1) by Pfannkuch, F, Bentley, P, Schnebli, H P

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Development of Eglin c as a drug: pharmacokinetics by Nick, H P, Probst, A, Schnebli, H P

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Preliminary crystallographic data on the complex of bovine alpha-chymotrypsin with the recombinant proteinase inhibitor eglin c from Hirudo medicinalis by Pugliese, L, Gatti, G, Bolognesi, M, Coda, A, Menegatti, E, Schnebli, H P, Ascenzi, P, Amiconi, G

“…The molecular complex built by bovine alpha-chymotrypsin and the recombinant proteinase inhibitor eglin c from Hirudo medicinalis has been crystallized from…”
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Isolation and characterization of an enkephalin-degrading aminopeptidase from rat brain by Schnebli, H P, Phillipps, M A, Barclay, R K

“…An enkephalin-degrading aminopeptidase from rat brain extracts has been purified to apparent homogeneity. This enzyme cleaves the N-terminal tyrosine from…”
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Selective Inhibition of Growth of Transformed Cells by Protease Inhibitors by Schnebli, Hans Peter, Burger, Max M.

“…Five protease inhibitors with different modes of action were found to reduce the growth of transformed mouse (Py3T3, SV3T3, and 3T12) and hamster (PyBHK)…”
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Quantitation of human leukocyte elastase, cathepsin G, alpha-2-macroglobulin and alpha-1-proteinase inhibitor in osteoarthrosis and rheumatoid arthritis synovial fluids by Virca, G D, Mallya, R K, Pepys, M B, Schnebli, H P

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