Search Results - "Schnabel, Robert"

Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds by Saatchi, Mahdi, Schnabel, Robert D, Taylor, Jeremy F, Garrick, Dorian J

“…The availability of high-density SNP assays including the BovineSNP50 (50 K) enables the identification of novel quantitative trait loci (QTL) and improvement…”
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Development and Characterization of a High Density SNP Genotyping Assay for Cattle by Matukumalli, Lakshmi K, Lawley, Cynthia T, Schnabel, Robert D, Taylor, Jeremy F, Allan, Mark F, Heaton, Michael P, O'Connell, Jeff, Moore, Stephen S, Smith, Timothy P.L, Sonstegard, Tad S, Van Tassell, Curtis P

“…The success of genome-wide association (GWA) studies for the detection of sequence variation affecting complex traits in human has spurred interest in the use…”
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Powerful detection of polygenic selection and evidence of environmental adaptation in US beef cattle by Rowan, Troy N, Durbin, Harly J, Seabury, Christopher M, Schnabel, Robert D, Decker, Jared E

“…Selection on complex traits can rapidly drive evolution, especially in stressful environments. This polygenic selection does not leave intense sweep signatures…”
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Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs by Marsden, Clare D., Vecchyo, Diego Ortega-Del, O’Brien, Dennis P., Taylor, Jeremy F., Ramirez, Oscar, Vilà, Carles, Marques-Bonet, Tomas, Schnabel, Robert D., Wayne, Robert K., Lohmueller, Kirk E.

“…Population bottlenecks, inbreeding, and artificial selection can all, in principle, influence levels of deleterious genetic variation. However, the relative…”
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Biomarker-based high-throughput sperm phenotyping: Andrology in the age of precision medicine and agriculture by Tirpak, Filip, Hamilton, Lauren E., Schnabel, Robert D., Sutovsky, Peter

“…Reproductive efficiency is crucial for animal agriculture. This economically important aspect can be influenced by environmental burdens, nutritional…”
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Genome-wide association analyses identify genotype-by-environment interactions of growth traits in Simmental cattle by Braz, Camila U., Rowan, Troy N., Schnabel, Robert D., Decker, Jared E.

“…Understanding genotype-by-environment interactions (G × E) is crucial to understand environmental adaptation in mammals and improve the sustainability of…”
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Identification of genomic variants causing sperm abnormalities and reduced male fertility by Taylor, Jeremy F., Schnabel, Robert D., Sutovsky, Peter

“…•Over 3000 cattle have now been whole genome sequenced.•More than 120 million bovine variants have been discovered.•Variants with gene regulation or expression…”
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Genome-wide association and genotype by environment interactions for growth traits in U.S. Red Angus cattle by Smith, Johanna L, Wilson, Miranda L, Nilson, Sara M, Rowan, Troy N, Schnabel, Robert D, Decker, Jared E, Seabury, Christopher M

“…Abstract Background Genotypic information produced from single nucleotide polymorphism (SNP) arrays has routinely been used to identify genomic regions…”
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New World cattle show ancestry from multiple independent domestication events by McTavish, Emily Jane, Decker, Jared E, Schnabel, Robert D, Taylor, Jeremy F, Hillis, David M

“…Previous archeological and genetic research has shown that modern cattle breeds are descended from multiple independent domestication events of the wild…”
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De novo assembly of the cattle reference genome with single-molecule sequencing by Rosen, Benjamin D, Bickhart, Derek M, Schnabel, Robert D, Koren, Sergey, Elsik, Christine G, Tseng, Elizabeth, Rowan, Troy N, Low, Wai Y, Zimin, Aleksey, Couldrey, Christine, Hall, Richard, Li, Wenli, Rhie, Arang, Ghurye, Jay, McKay, Stephanie D, Thibaud-Nissen, Françoise, Hoffman, Jinna, Murdoch, Brenda M, Snelling, Warren M, McDaneld, Tara G, Hammond, John A, Schwartz, John C, Nandolo, Wilson, Hagen, Darren E, Dreischer, Christian, Schultheiss, Sebastian J, Schroeder, Steven G, Phillippy, Adam M, Cole, John B, Van Tassell, Curtis P, Liu, George, Smith, Timothy P L, Medrano, Juan F

“…Abstract Background Major advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10–12 years. These…”
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Copy number variation of individual cattle genomes using next-generation sequencing by Bickhart, Derek M, Hou, Yali, Schroeder, Steven G, Alkan, Can, Cardone, Maria Francesca, Matukumalli, Lakshmi K, Song, Jiuzhou, Schnabel, Robert D, Ventura, Mario, Taylor, Jeremy F, Garcia, Jose Fernando, Van Tassell, Curtis P, Sonstegard, Tad S, Eichler, Evan E, Liu, George E

“…Copy number variations (CNVs) affect a wide range of phenotypic traits; however, CNVs in or near segmental duplication regions are often intractable. Using a…”
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Evidence of rare misassemblies in the bovine reference genome revealed by population genetic metrics by Qanbari, Saber, Schnabel, Robert D., Wittenburg, Dörte

“…Creation of the bovine reference assembly paved the way to develop the high‐throughput genotyping arrays of the single nucleotide polymorphisms (SNPs) based on…”
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Uncovering the architecture of selection in two Bos taurus cattle breeds by Rowan, Troy N., Schnabel, Robert D., Decker, Jared E.

“…Directional selection alters the genome via hard sweeps, soft sweeps, and polygenic selection. However, mapping polygenic selection is difficult because it…”
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Candidate lethal haplotypes and causal mutations in Angus cattle by Hoff, Jesse L, Decker, Jared E, Schnabel, Robert D, Taylor, Jeremy F

“…If unmanaged, high rates of inbreeding in livestock populations adversely impact their reproductive fitness. In beef cattle, historical selection strategies…”
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Review: Genomics of bull fertility by Taylor, Jeremy F., Schnabel, Robert D., Sutovsky, Peter

“…Fertility is one of the most economically important traits in both beef and dairy cattle production; however, only female fertility is typically subjected to…”
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Genome-wide association and genotype by environment interactions for growth traits in U.S. Gelbvieh cattle by Smith, Johanna L, Wilson, Miranda L, Nilson, Sara M, Rowan, Troy N, Oldeschulte, David L, Schnabel, Robert D, Decker, Jared E, Seabury, Christopher M

“…Single nucleotide polymorphism (SNP) arrays have facilitated discovery of genetic markers associated with complex traits in domestic cattle; thereby enabling…”
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Immunological Response to Single Pathogen Challenge with Agents of the Bovine Respiratory Disease Complex: An RNA-Sequence Analysis of the Bronchial Lymph Node Transcriptome by Tizioto, Polyana C, Kim, JaeWoo, Seabury, Christopher M, Schnabel, Robert D, Gershwin, Laurel J, Van Eenennaam, Alison L, Toaff-Rosenstein, Rachel, Neibergs, Holly L, Taylor, Jeremy F

“…Susceptibility to bovine respiratory disease (BRD) is multi-factorial and is influenced by stress in conjunction with infection by both bacterial and viral…”
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CRUMBLER: A tool for the prediction of ancestry in cattle by Crum, Tamar E, Schnabel, Robert D, Decker, Jared E, Regitano, Luciana C A, Taylor, Jeremy F

“…In many beef and some dairy production systems, crossbreeding is used to take advantage of breed complementarity and heterosis. Admixed animals are frequently…”
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Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation by Yurchenko, Andrey A., Daetwyler, Hans D., Yudin, Nikolay, Schnabel, Robert D., Vander Jagt, Christy J., Soloshenko, Vladimir, Lhasaranov, Bulat, Popov, Ruslan, Taylor, Jeremy F., Larkin, Denis M.

“…Domestication and selective breeding has resulted in over 1000 extant cattle breeds. Many of these breeds do not excel in important traits but are adapted to…”
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Detection of selective sweeps in cattle using genome-wide SNP data by Ramey, Holly R, Decker, Jared E, McKay, Stephanie D, Rolf, Megan M, Schnabel, Robert D, Taylor, Jeremy F

“…The domestication and subsequent selection by humans to create breeds and biological types of cattle undoubtedly altered the patterning of variation within…”
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