Search Results - "Schmutzler, C"

Regulation of the sodium/iodide symporter by retinoids--a review by Schmutzler, C

“…Decrease or loss of iodide uptake, due to impaired expression and/or function of the sodium/iodide-symporter (NIS), is a major obstacle to the treatment of…”
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Clinical impact of retinoids in redifferentiation therapy of advanced thyroid cancer: final results of a pilot study by SIMON, D, KÖRBER, C, RÖHER, H. D, REINERS, C, KRAUSCH, M, SEGERING, J, GROTH, P, GÖRGES, R, GRÜNWALD, F, MÜLLER-GÄRTNER, H. W, SCHMUTZLER, C, KÖHRLE, J

“…Differentiated thyroid cancer is a malignant tumour that has a fairly good prognosis, with patients surviving for many years. Multimodal therapy with surgery,…”
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Retinoic Acid Increases Sodium/Iodide Symporter mRNA Levels in Human Thyroid Cancer Cell Lines and Suppresses Expression of Functional Symporter in Nontransformed FRTL-5 Rat Thyroid Cells by Schmutzler, C., Winzer, R., Meissner-Weigl, J., Köhrle, J.

“…Decreased iodide uptake in de-differentiated thyroid carcinomas impedes radioiodide therapy. RT-PCR analysis revealed reduced expression of Na+/I−symporter…”
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Human thyroid carcinoma cell lines show different retinoic acid receptor repertoires and retinoid responses by Schmutzler, C, Hoang-Vu, C, Ruger, B, Kohrle, J

“…OBJECTIVE: Disturbed expression of retinoic acid (RA) receptors (RAR/RXR) contributes to the pathogenesis and tumor progression of epithelial carcinomas…”
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Taxonomic diversity of ant (Hymenoptera: Formicidae) assemblages in forest remnants in the Northeast of Argentina by Larrea, Dario D., Achitte-Schmutzler, Helga C., Sánchez, José M.

“…Argentina is among the ten countries in the world with loss of large areas of forests in recent years. Deforestation leads to an inevitable loss of…”
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The promoter of the human sodium/iodide-symporter gene responds to retinoic acid by Schmutzler, C., Schmitt, T.L., Glaser, F., Loos, U., Köhrle, J.

“…It was shown previously that hNIS mRNA expression is stimulated by retinoic acid (RA) in human follicular thyroid carcinoma cell lines FTC-133 and FTC-238, and…”
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First description of the male of the spider Tibellus paraguensis Simon, 1897 (Araneae: Philodromidae), with new distribution records by Achitte-Schmutzler, Helga C, Rubio, Gonzalo D

“…The genus Tibellus Simon, 1875 currently includes 51 species (WSC 2016); it presents some taxonomic difficulties, due to morphological variability, and…”
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Implications of the molecular characterization of the sodium-iodide symporter (NIS) by Schmutzler, C, Köhrle, J

“…The recently cloned sodium-iodide symporter (NIS) represents a key molecule for thyroid function by efficiently accumulating iodide from the circulation into…”
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Double heterozygosity for mutations in BRCA1 and BRCA2 in German breast cancer patients: implications on test strategies and clinical management by Heidemann, Simone, Fischer, Christine, Engel, Christoph, Fischer, Barbara, Harder, Lana, Schlegelberger, Brigitte, Niederacher, Dieter, Goecke, Timm O., Doelken, Sandra C., Dikow, Nicola, Jonat, Walter, Morlot, Susanne, Schmutzler, Rita C., Arnold, Norbert K.

“…Double heterozygosity for disease-causing BRCA1 and BRCA2 mutations is a very rare condition in most populations. Here we describe genetic and clinical data of…”
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Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules by Brtko, J, Bobálová, J, Podoba, J, Schmutzler, C, Köhrle, J

“…The majority of thyroid adenomas are of clonal origin. In a subset of toxic adenomas (TAs) and cold nodules (CNs) activating mutations in the thyrotropin (TSH)…”
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Expression of Selenoproteins in Various Rat and Human Tissues and Cell Lines by Dreher, I., Schmutzler, C., Jakob, F., Köhrle, J.

“…Various rat and human tissues and cell lines naturally exposed to endogenous or exogenous oxidative stress were examined for their pattern of selenoprotein…”
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Effects of retinoids and role of retinoic acid receptors in human thyroid carcinomas and cell lines derived therefrom by Schmutzler, C, Brtko, J, Bienert, K, Köhrle, J

“…Retinoic acids (RAs), well characterized regulators of proliferation and differentiation, partly re-differentiate follicular thyroid carcinoma cell lines…”
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Redifferentiation therapy of differentiated thyroid carcinoma with retinoic acid: basics and first clinical results by Simon, D, Köhrle, J, Schmutzler, C, Mainz, K, Reiners, C, Röher, H D

“…Retinoic acids (RA) regulate growth and differentiation of normal epithelial tissue. They have been employed in anticancer treatment and showed positive…”
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Thyroid gland goes genomic by Bennett, Simon T., Schmutzler, Cornelia

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Retinoic Acid Increases Sodium/Iodide Symporter mRNA Levels in Human Thyroid Cancer Cell Lines and Suppresses Expression of Functional Symporter in Nontransformed FRTL-5 Rat Thyroid Cells by Schmutzler, C., Winzer, R., Meissner-Weigl, J., Köhrle, J.

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The primary structure of the Pol-RFamide neuropeptide precursor protein from the hydromedusa Polyorchis penicillatus indicates a novel processing proteinase activity by SCHMUTZLER, C, DIEKHOFF, D, GRIMMELIKHUIJZEN, C. J. P

“…Neuropeptides containing the C-terminal sequence Arg-Phe-NH2 (RFamide) occur throughout the Animal Kingdom and are abundant in evolutionarily 'old' nervous…”
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Primary Structure of the Precursor for the Sea Anemone Neuropeptide Antho-RFamide (<Glu-Gly-Arg-Phe-NH2) by Darmer, Dorothea, Schmutzler, Cornelia, Diekhoff, Dagmar, Cornelis J. P. Grimmelikhuijzen

“…Neuropeptides containing the carboxyl-terminal sequence Arg-Phe-NH2are found throughout the animal kingdom and are important substances mediating neuronal…”
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Identification of a novel type of processing sites in the precursor for the sea anemone neuropeptide Antho-RFamide (<Glu-Gly-Arg-Phe-NH2) from Anthopleura elegantissima by SCHMUTZLER, C, DARMER, D, DIEKHOFF, D, GRIMMELIKHUIJZEN, C. J. P

“…Neuropeptides are synthesized as large precursor proteins that undergo posttranslational cleavages and modifications to produce bioactive peptides. Here, we…”
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Effects of a 5-day treatment with the UV-filter octyl-methoxycinnamate (OMC) on the function of the hypothalamo-pituitary–thyroid function in rats by Klammer, Holger, Schlecht, Christiane, Wuttke, Wolfgang, Schmutzler, Cornelia, Gotthardt, Inka, Köhrle, Josef, Jarry, Hubertus

“…Abstract Octyl-methoxycinnamate (OMC) is one of the most frequently used UV-filters in sunscreens to protect the skin against the noxious influence of UV…”
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Endocrine active compounds affect thyrotropin and thyroid hormone levels in serum as well as endpoints of thyroid hormone action in liver, heart and kidney by Schmutzler, Cornelia, Hamann, Inka, Hofmann, Peter J., Kovacs, Gabor, Stemmler, Luise, Mentrup, Birgit, Schomburg, Lutz, Ambrugger, Petra, Grüters, Annette, Seidlova-Wuttke, Dana, Jarry, Hubertus, Wuttke, Wolfgang, Köhrle, Josef

“…To assess interference with endocrine regulation of the thyroid axis, rats (female, ovariectomised) were treated for 12 weeks with the suspected endocrine…”
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