Search Results - "Schmuck, Eric G"

Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors by Zhang, Jianhua, Tao, Ran, Campbell, Katherine F., Carvalho, Juliana L., Ruiz, Edward C., Kim, Gina C., Schmuck, Eric G., Raval, Amish N., da Rocha, André Monteiro, Herron, Todd J., Jalife, José, Thomson, James A., Kamp, Timothy J.

“…Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. The limited availability of human CFs from native heart impedes…”
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Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors by Lalit, Pratik A., Salick, Max R., Nelson, Daryl O., Squirrell, Jayne M., Shafer, Christina M., Patel, Neel G., Saeed, Imaan, Schmuck, Eric G., Markandeya, Yogananda S., Wong, Rachel, Lea, Martin R., Eliceiri, Kevin W., Hacker, Timothy A., Crone, Wendy C., Kyba, Michael, Garry, Daniel J., Stewart, Ron, Thomson, James A., Downs, Karen M., Lyons, Gary E., Kamp, Timothy J.

“…Several studies have reported reprogramming of fibroblasts into induced cardiomyocytes; however, reprogramming into proliferative induced cardiac progenitor…”
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Cultured cardiac fibroblasts and myofibroblasts express Sushi Containing Domain 2 and assemble a unique fibronectin rich matrix by Schmuck, Eric G., Roy, Sushmita, Dhillon, Anisa, Walker, Sydney, Spinali, Keith, Colevas, Sophia, Zhou, Tianhua, Chhabra, Gagan, Liu, Yuming, Kader Sagar, Md Abdul, Childs, Charlie J., Kink, John A., Eliceiri, Kevin W., Hematti, Peiman, Raval, Amish N.

“…Cardiac fibroblasts and myofibroblasts assemble and maintain extracellular matrix during normal development and following injury. Culture expansion of these…”
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A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats by Lindholm, Christopher R., Ertel, Rebecca L., Bauwens, Jake D., Schmuck, Eric G., Mulligan, Jacob D., Saupe, Kurt W.

“…Consumption of a high-fat diet (HFD) in experimental animal models initiates a series of molecular events and outcomes, including insulin resistance and…”
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Caveolae-Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis by Egorov, Yuriy V, Lang, Di, Tyan, Leonid, Turner, Daniel, Lim, Evi, Piro, Zachary D, Hernandez, Jonathan J, Lodin, Rylie, Wang, Rose, Schmuck, Eric G, Raval, Amish N, Ralphe, Carter J, Kamp, Timothy J, Rosenshtraukh, Leonid V, Glukhov, Alexey V

“…Background Atrial fibrillation often occurs in the setting of hypertension and associated atrial dilation with pathologically increased cardiomyocyte stretch…”
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Biodistribution and Clearance of Human Mesenchymal Stem Cells by Quantitative Three‐Dimensional Cryo‐Imaging After Intravenous Infusion in a Rat Lung Injury Model by Schmuck, Eric G., Koch, Jill M., Centanni, John M., Hacker, Timothy A., Braun, Rudolf K., Eldridge, Marlowe, Hei, Derek J., Hematti, Peiman, Raval, Amish N.

“…To study three‐dimensional (3D) cryo‐imaging to measure cell biodistribution and clearance after intravenous infusion, the authors established a lung injury…”
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Impact of statins on cellular respiration and de‐differentiation of myofibroblasts in human failing hearts by Emelyanova, Larisa, Sra, Amar, Schmuck, Eric G., Raval, Amish N., Downey, Francis X., Jahangir, Arshad, Rizvi, Farhan, Ross, Gracious R.

“…Aims Fibroblast to myofibroblast trans‐differentiation with altered bioenergetics precedes cardiac fibrosis (CF). Either prevention of differentiation or…”
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Identifying molecular and functional similarities and differences between human primary cardiac valve interstitial cells and ventricular fibroblasts by Floy, Martha E, Shabnam, Fathima, Givens, Sophie E, Patil, Vaidehi A, Ding, Yunfeng, Li, Grace, Roy, Sushmita, Raval, Amish N, Schmuck, Eric G, Masters, Kristyn S, Ogle, Brenda M, Palecek, Sean P

“…Fibroblasts are mesenchymal cells that predominantly produce and maintain the extracellular matrix (ECM) and are critical mediators of injury response. In the…”
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Beneficial effects of mesenchymal stem cell delivery via a novel cardiac bioscaffold on right ventricles of pulmonary arterial hypertensive rats by Schmuck, Eric G, Hacker, Timothy A, Schreier, David A, Chesler, Naomi C, Wang, Zhijie

“…Right ventricular failure (RVF) is a common cause of death in patients suffering from pulmonary arterial hypertension (PAH). The current treatment for PAH only…”
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Human left ventricular cardiac fibroblasts undergo a dynamic shift in secretome and gene expression toward a cardiac myofibroblast phenotype during early passage in typical culture expansion conditions by Schmuck, Eric G, Roy, Sushmita, Zhou, Tianhua, Wille, Delani, Reeves, Sophie Mixon, Conklin, James, Raval, Amish N

“…Cardiac fibroblasts (CFs) are critical components of the cardiac niche and primarily responsible for assembly and maintenance of the cardiac extracellular…”
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Induced cardiac progenitor cells repopulate decellularized mouse heart scaffolds and differentiate to generate cardiac tissue by Alexanian, Ruben A., Mahapatra, Kaushiki, Lang, Di, Vaidyanathan, Ravi, Markandeya, Yogananda S., Gill, Ramandeep K., Zhai, Andrew J., Dhillon, Anisa, Lea, Martin R., Abozeid, Sara, Schmuck, Eric G., Raval, Amish N., Eckhardt, Lee L., Glukhov, Alexey V., Lalit, Pratik A., Kamp, Timothy J.

“…Native myocardium has limited regenerative potential post injury. Advances in lineage reprogramming have provided promising cellular sources for regenerative…”
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Natural Sources of Extracellular Matrix for Cardiac Repair by Spinali, Keith L, Schmuck, Eric G

“…Tissue engineering and regenerative medicine have adopted the use of extracellular matrix (ECM) as a cell delivery device and bioactive regenerative agent. To…”
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Bilateral administration of autologous CD133+ cells in ambulatory patients with refractory critical limb ischemia: lessons learned from a pilot randomized, double-blind, placebo-controlled trial by Raval, Amish N, Schmuck, Eric G, Tefera, Girma, Leitzke, Cathlyn, Ark, Cassondra Vander, Hei, Derek, Centanni, John M, de Silva, Ranil, Koch, Jill, Chappell, Richard G, Hematti, Peiman

“…Abstract Background aims CD133+ cells confer angiogenic potential and may be beneficial for the treatment of critical limb ischemia (CLI). However, patient…”
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Cardiac fibroblast derived matrix-educated macrophages express VEGF and IL-6, and recruit mesenchymal stromal cells by Roy, Sushmita, Spinali, Keith, Schmuck, Eric G., Kink, John A., Hematti, Peiman, Raval, Amish N.

“…The polarization of monocytes into macrophages that possess anti-inflammatory and pro-angiogenic properties could provide a novel therapeutic strategy for…”
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Cold tolerance, cold-induced hyperphagia, and nonshivering thermogenesis are normal in α₁-AMPK-/- mice by Bauwens, Jake D, Schmuck, Eric G, Lindholm, Christopher R, Ertel, Rebecca L, Mulligan, Jacob D, Hovis, Ian, Viollet, Benoit, Saupe, Kurt W

“…Recent studies indicate that a substantial amount of metabolically active brown adipose tissue (BAT) exists in adult humans. Given the unique ability of BAT to…”
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Cardiopulmonary and histological characterization of an acute rat lung injury model demonstrating safety of mesenchymal stromal cell infusion by Braun, Rudolf K, Koch, Jill M, Hacker, Timothy A, Pegelow, David, Kim, Jaehyup, Raval, Amish N, Schmuck, Eric G, Schwahn, Denise J, Hei, Derek J, Centanni, John M, Eldridge, Marlowe, Hematti, Peiman

“…Abstract Background aims In the field of cellular therapy, potential cell entrapment in the lungs following intravenous administration in a compromised or…”
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Cardiac Fibroblast-Derived 3D Extracellular Matrix Seeded with Mesenchymal Stem Cells as a Novel Device to Transfer Cells to the Ischemic Myocardium by Schmuck, Eric G., Mulligan, Jacob D., Ertel, Rebecca L., Kouris, Nicholas A., Ogle, Brenda M., Raval, Amish N., Saupe, Kurt W.

“…Demonstrate a novel manufacturing method to generate extracellular matrix scaffolds from cardiac fibroblasts (CF-ECM) as a therapeutic mesenchymal stem…”
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Lineage Reprogramming of Fibroblasts to Proliferative Induced Cardiac Progenitor Cells by Defined Factors by Lalit, Pratik A., Salick, Max R., Nelson, Daryl O., Squirrell, Jayne M., Shafer, Christina M., Patel, Neel G., Saeed, Imaan, Schmuck, Eric G., Markandeya, Yogananda S., Wong, Rachel, Lea, Martin R., Eliceiri, Kevin W., Hacker, Timothy, Crone, Wendy C., Kyba, Michael, Garry, Daniel J., Stewart, Ron, Thomson, James A., Downs, Karen M., Lyons, Gary E., Kamp, Timothy J.

“…Several studies have reported reprogramming of fibroblasts to induced cardiomyocytes; however, reprogramming to proliferative induced cardiac progenitor cells…”
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Macrophages Educated with Exosomes from Primed Mesenchymal Stem Cells Treat Acute Radiation Syndrome by Promoting Hematopoietic Recovery by Kink, John A., Forsberg, Matthew H., Reshetylo, Sofiya, Besharat, Soroush, Childs, Charlie J., Pederson, Jessica D., Gendron-Fitzpatrick, Annette, Graham, Melissa, Bates, Paul D., Schmuck, Eric G., Raval, Amish, Hematti, Peiman, Capitini, Christian M.

“…•Activation of human mesenchymal stem cells, in a lipopolysaccharide (LPS) dose-dependent manner, generates exosomes that can polarize human macrophages into…”
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Intravenous Followed by X-ray Fused with MRI-Guided Transendocardial Mesenchymal Stem Cell Injection Improves Contractility Reserve in a Swine Model of Myocardial Infarction by Schmuck, Eric G., Koch, Jill M., Hacker, Timothy A., Hatt, Charles R., Tomkowiak, Michael T., Vigen, Karl K., Hendren, Nicholas, Leitzke, Cathlyn, Zhao, Ying-qi, Li, Zhanhai, Centanni, John M., Hei, Derek J., Schwahn, Denise, Kim, Jaehyup, Hematti, Peiman, Raval, Amish N.

“…The aim of this study is to determine the effects of early intravenous (IV) infusion later followed by transendocardial (TE) injection of allogeneic…”
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