Search Results - "Schmitz‐Spanke, Simone"

A systematic review: metabolomics‐based identification of altered metabolites and pathways in the skin caused by internal and external factors by Masutin, Viktor, Kersch, Christian, Schmitz‐Spanke, Simone

“…The skin's ability to function optimally is affected by many diverse factors. Metabolomics has a great potential to improve our understanding of the underlying…”
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Mode of action-based risk assessment of genotoxic carcinogens by Hartwig, Andrea, Arand, Michael, Epe, Bernd, Guth, Sabine, Jahnke, Gunnar, Lampen, Alfonso, Martus, Hans-Jörg, Monien, Bernhard, Rietjens, Ivonne M. C. M., Schmitz-Spanke, Simone, Schriever-Schwemmer, Gerlinde, Steinberg, Pablo, Eisenbrand, Gerhard

“…The risk assessment of chemical carcinogens is one major task in toxicology. Even though exposure has been mitigated effectively during the last decades, low…”
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Recent advances in the use of Sus scrofa (pig) as a model system for proteomic studies by Verma, Nisha, Rettenmeier, Albert W, Schmitz-Spanke, Simone

“…Of the numerous animal models available for proteomic studies only a small number have been successfully used in understanding human biology. To date, rodents…”
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Syncarcinogenesis of natural UV radiation and polycyclic aromatic hydrocarbons in the development of squamous cell carcinomas of the skin? by Weistenhöfer, Wobbeke, Lutz, Regina, Hiller, Julia, Schmitz‐Spanke, Simone, Drexler, Hans

“…Summary Squamous cell carcinomas (SCC) of the skin can be induced by occupational exposures to polycyclic aromatic hydrocarbons (PAHs), as in tar and soot, or…”
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Assessment of the different skin sensitization potentials of irritants and allergens as single substances and in combination using the KeratinoSens assay by De Rentiis, Anna M. A., Pink, Mario, Verma, Nisha, Schmitz‐Spanke, Simone

“…Background People are exposed to mixtures containing allergens and irritants often causing contact dermatitis. Therefore, regulatory authorities require…”
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Synkanzerogenese von natürlicher UV‐Strahlung und polyzyklischen aromatischen Kohlenwasserstoffen bei der Entstehung von Plattenepithelkarzinomen der Haut? by Weistenhöfer, Wobbeke, Lutz, Regina, Hiller, Julia, Schmitz‐Spanke, Simone, Drexler, Hans

“…Zusammenfassung Plattenepithelkarzinome der Haut können durch berufsbedingte Exposition gegenüber polyzyklischen aromatischen Kohlenwasserstoffen (PAK) wie in…”
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Protein expression profiling in chemical carcinogenesis: A proteomic-based approach by Schmitz-Spanke, Simone, Rettenmeier, Albert W

“…The simultaneous analysis of a wide array of proteins may provide valuable information on the activation and suppression of cellular systems at different…”
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Differential effects of benzo[a]pyrene exposure on glutathione and purine metabolism in keratinocytes: Dose‐dependent and UV co‐exposure effects by Masutin, Viktor, Kersch, Christian, Alsaleh, Rasha, Schmitz‐Spanke, Simone

“…Polycyclic aromatic hydrocarbons with the key substance benzo[a]pyrene (B[a]P) are widespread pollutants in the environment and at working places. Nonetheless,…”
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A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure by Verma, Nisha, Pink, Mario, Schmitz-Spanke, Simone

“…Toxicological studies propose that exposure to carbon black nanoparticles induces organ injuries and inflammatory responses. Besides, current understanding of…”
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Review on proteomic analyses of benzo[a]pyrene toxicity by Verma, Nisha, Pink, Mario, Rettenmeier, Albert W., Schmitz-Spanke, Simone

“…Benzo[a]pyrene (BaP), a five‐ring polycyclic aromatic hydrocarbon, is a well‐recognized environmental pollutant. Coal‐processing waste products, petroleum…”
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Benzo[a]pyrene-induced metabolic shift from glycolysis to pentose phosphate pathway in the human bladder cancer cell line RT4 by Verma, Nisha, Pink, Mario, Boland, Stefan, Rettenmeier, Albert W., Schmitz-Spanke, Simone

“…Benzo[a]pyrene (B[a]P), a well-known polyaromatic hydrocarbon, is known for its lung carcinogenicity, however, its role in bladder cancer development is still…”
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CBB staining protocol with higher sensitivity and mass spectrometric compatibility by Pink, Mario, Verma, Nisha, Rettenmeier, Albert W, Schmitz-Spanke, Simone

“…Various CBB-based methods for staining proteins separated by 2-D gel electrophoresis were compared with regard to sensitivity and resolution. A modified Kang's…”
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The chemical composition of secondary organic aerosols regulates transcriptomic and metabolomic signaling in an epithelial-endothelial in vitro coculture by Offer, Svenja, Di Bucchianico, Sebastiano, Czech, Hendryk, Pardo, Michal, Pantzke, Jana, Bisig, Christoph, Schneider, Eric, Bauer, Stefanie, Zimmermann, Elias J, Oeder, Sebastian, Hartner, Elena, Gröger, Thomas, Alsaleh, Rasha, Kersch, Christian, Ziehm, Till, Hohaus, Thorsten, Rüger, Christopher P, Schmitz-Spanke, Simone, Schnelle-Kreis, Jürgen, Sklorz, Martin, Kiendler-Scharr, Astrid, Rudich, Yinon, Zimmermann, Ralf

“…The formation of secondary organic aerosols (SOA) by atmospheric oxidation reactions substantially contributes to the burden of fine particulate matter (PM ),…”
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Correction to: Mode of action-based risk assessment of genotoxic carcinogens by Hartwig, Andrea, Arand, Michael, Epe, Bernd, Guth, Sabine, Jahnke, Gunnar, Lampen, Alfonso, Martus, Hans-Jörg, Monien, Bernhard, Rietjens, Ivonne M. C. M., Schmitz-Spanke, Simone, Schriever-Schwemmer, Gerlinde, Steinberg, Pablo, Eisenbrand, Gerhard

“…The author would like to thank N. Bakhiya, S. Hessel-Pras, B. Sachse, and B. Dusemund for their support in the chapter about pyrrolizidine alkaloids…”
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Gel-based separation of phosphoproteins in samples stored in urea/thiourea after precipitation by lanthanum chloride by Pink, Mario, Stein, Christine, Verma, Nisha, Rettenmeier, Albert W., Schmitz-Spanke, Simone

“…The recent introduction of the La3+ precipitation method for the enrichment of phosphoproteins allows a gel‐based analysis of these posttranslationally…”
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Proteome and phosphoproteome of primary cultured pig urothelial cells by Verma, Nisha, Bäuerlein, Carolin, Pink, Mario, Rettenmeier, Albert W., Schmitz-Spanke, Simone

“…Epithelial tissue lining the inner side of the urinary bladder is the most common target for bladder cancer‐related diseases. Bladders of freshly slaughtered…”
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Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton by Atemnkeng, Veronika Anyigoh, Pink, Mario, Schmitz-Spanke, Simone, Wu, Xian-Jun, Dong, Liang-Liang, Zhao, Kai-Hong, May, Caroline, Laufer, Stefan, Langer, Barbara, Kaiser, Annette

“…Primaquine, an 8-aminoquinoline, is the only drug which cures the dormant hypnozoites of persistent liver stages from P. vivax. Increasing resistance needs the…”
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Toxicogenomics – What added Value Do These Approaches Provide for Carcinogen Risk Assessment? by Schmitz-Spanke, Simone

“…It is still a major challenge to protect humans at workplaces and in the environment. To cope with this task, it is a prerequisite to obtain detailed…”
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Benchmark dose analyses of toxic endpoints in lung cells provide sensitivity and toxicity ranking across metal oxide nanoparticles and give insights into the mode of action by Pink, Mario, Verma, Nisha, Schmitz-Spanke, Simone

“…•Benchmark dose (BMD) analysis is an effective tool to rank sensitivity and toxicity.•BMD analysis was used to support modes of action basing on endpoint…”
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Differential effects of benzopyrene exposure on glutathione and purine metabolism in keratinocytes: Dose‐dependent and UV co‐exposure effects by Masutin, Viktor, Kersch, Christian, Alsaleh, Rasha, Simone Schmitz‐Spanke

“…Polycyclic aromatic hydrocarbons with the key substance benzo[a]pyrene (B[a]P) are widespread pollutants in the environment and at working places. Nonetheless,…”
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