Search Results - "Schmitz, Karl R"

Bioinformatic identification of ClpI, a distinct class of Clp unfoldases in Actinomycetota by Jiang, Jialiu, Schmitz, Karl R

“…All clades of bacteria possess Hsp100/Clp family unfoldase enzymes that contribute to aspects of protein quality control. In Actinomycetota, these include…”
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Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains by Schmitz, Karl R., Bagchi, Atrish, Roovers, Rob C., van Bergen en Henegouwen, Paul M.P., Ferguson, Kathryn M.

“…The epidermal growth factor receptor (EGFR) is implicated in human cancers and is the target of several classes of therapeutic agents, including antibody-based…”
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Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine by Stinson, Benjamin M., Nager, Andrew R., Glynn, Steven E., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.

“…ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power conformational changes that unfold and translocate target proteins into…”
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Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine by Cordova, Juan Carlos, Olivares, Adrian O., Shin, Yongdae, Stinson, Benjamin M., Calmat, Stephane, Schmitz, Karl R., Aubin-Tam, Marie-Eve, Baker, Tania A., Lang, Matthew J., Sauer, Robert T.

“…ClpXP and other AAA+ proteases recognize, mechanically unfold, and translocate target proteins into a chamber for proteolysis. It is not known whether these…”
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Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation by Amor, Alvaro J., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.

“…IGF‐motif loops project from the hexameric ring of ClpX and are required for docking with the self‐compartmentalized ClpP peptidase, which consists of…”
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Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery by Schmitz, Karl R, Carney, Daniel W, Sello, Jason K, Sauer, Robert T

“…Significance Caseinolytic peptidase P (ClpP) normally collaborates with ATPases associated with diverse activities (AAA+) partner proteins, such as ClpX and…”
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Structural basis for inhibition of the epidermal growth factor receptor by cetuximab by Li, Shiqing, Schmitz, Karl R., Jeffrey, Philip D., Wiltzius, Jed J.W., Kussie, Paul, Ferguson, Kathryn M.

“…Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular regions have identified an unexpected mechanism for ligand-induced…”
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Kinase Associated-1 Domains Drive MARK/PAR1 Kinases to Membrane Targets by Binding Acidic Phospholipids by Moravcevic, Katarina, Mendrola, Jeannine M., Schmitz, Karl R., Wang, Yu-Hsiu, Slochower, David, Janmey, Paul A., Lemmon, Mark A.

“…Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in location-dependent regulation of many protein kinases. Here, we identify the…”
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Comparison of Saccharomyces cerevisiae F-BAR Domain Structures Reveals a Conserved Inositol Phosphate Binding Site by Moravcevic, Katarina, Alvarado, Diego, Schmitz, Karl R., Kenniston, Jon A., Mendrola, Jeannine M., Ferguson, Kathryn M., Lemmon, Mark A.

“…F-BAR domains control membrane interactions in endocytosis, cytokinesis, and cell signaling. Although they are generally thought to bind curved membranes…”
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Identification of Arginine Phosphorylation in Mycolicibacterium smegmatis by Ogbonna, Emmanuel C, Anderson, Henry R, Schmitz, Karl R

“…Tuberculosis is a leading cause of worldwide infectious mortality. The prevalence of multidrug-resistant Mycobacterium tuberculosis infections drives an urgent…”
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PtdIns4P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking by Wood, Christopher S, Schmitz, Karl R, Bessman, Nicholas J, Setty, Thanuja Gangi, Ferguson, Kathryn M, Burd, Christopher G

“…Targeting and retention of resident integral membrane proteins of the Golgi apparatus underly the function of the Golgi in glycoprotein and glycolipid…”
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Golgi Localization of Glycosyltransferases Requires a Vps74p Oligomer by Schmitz, Karl R., Liu, Jingxuan, Li, Shiqing, Setty, Thanuja Gangi, Wood, Christopher S., Burd, Christopher G., Ferguson, Kathryn M.

“…The mechanism of glycosyltransferase localization to the Golgi apparatus is a long-standing question in secretory cell biology. All Golgi glycosyltransferases…”
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Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1 by Ogbonna, Emmanuel C, Anderson, Henry R, Beardslee, Patrick C, Bheemreddy, Priyanka, Schmitz, Karl R

“…The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important…”
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Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase by Schmitz, Karl R., Sauer, Robert T.

“…Summary Mycobacterial Clp‐family proteases function via collaboration of the heteromeric ClpP1P2 peptidase with a AAA+ partner, ClpX or ClpC1. These enzymes…”
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Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in Vitro by Schmitz, Karl R., Handy, Emma L., Compton, Corey L., Gupta, Shashank, Bishai, William R., Sauer, Robert T., Sello, Jason K.

“…Proteolytic complexes in Mycobacterium tuberculosis (Mtb), the deadliest bacterial pathogen, are major foci in tuberculosis drug development programs. The Clp…”
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Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity by Carney, Daniel W, Schmitz, Karl R, Truong, Jonathan V, Sauer, Robert T, Sello, Jason K

“…The cyclic acyldepsipeptide (ADEP) antibiotics are a new class of antibacterial agents that kill bacteria via a mechanism that is distinct from all clinically…”
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Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX by Stinson, Benjamin M, Baytshtok, Vladimir, Schmitz, Karl R, Baker, Tania A, Sauer, Robert T

“…The hexameric ClpX AAA+ ATPase requires subunit asymmetry and switching between nucleotide-loadable and nucleotide-unloadable conformations for cooperative ATP…”
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Interaction of antibodies with ErbB receptor extracellular regions by Schmitz, Karl R., Ferguson, Kathryn M.

“…Antibodies to the extracellular region of the ErbB receptors have played key roles in the development of a mechanistic understanding of this family of receptor…”
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Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase by Compton, Corey L, Schmitz, Karl R, Sauer, Robert T, Sello, Jason K

“…There is rapidly mounting evidence that intracellular proteases in bacteria are compelling targets for antibacterial drugs. Multiple reports suggest that the…”
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A Simple Fragment of Cyclic Acyldepsipeptides Is Necessary and Sufficient for ClpP Activation and Antibacterial Activity by Carney, Daniel W., Compton, Corey L., Schmitz, Karl R., Stevens, Julia P., Sauer, Robert T., Sello, Jason K.

“…The development of new antibacterial agents, particularly those with unique biological targets, is essential to keep pace with the inevitable emergence of drug…”
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