Search Results - "Schmitz, Jorn E."

A Nonfucosylated Variant of the anti-HIV-1 Monoclonal Antibody b12 Has Enhanced FcγRIIIa-Mediated Antiviral Activity In Vitro but Does Not Improve Protection against Mucosal SHIV Challenge in Macaques by MOLDT, Brian, SHIBATA-KOYAMA, Mami, DUGAST, Anne-Sophie, PARREN, Paul W. H. I, NIMMERJAHN, Falk, EVANS, David T, ALTER, Galit, FORTHAL, Donald N, SCHMITZ, Jörn E, IIDA, Shigeru, POIGNARD, Pascal, WATKINS, David I, RAKASZ, Eva G, HESSELL, Ann J, BURTONA, Dennis R, SCHULTZ, Niccole, KANDA, Yutaka, CAMERON DUNLOP, D, FINSTAD, Samantha L, CHENGGANG JIN, LANDUCCI, Gary, ALPERT, Michael D

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Comparison of Simian Immunodeficiency Virus SIVagmVer Replication and CD4+ T-Cell Dynamics in Vervet and Sabaeus African Green Monkeys by GOLDSTEIN, Simoy, BROWN, Charles R, HIRSCH, Vanessa M, OURMANOV, Ilnour, PANDREA, Ivona, BUCKLER-WHITE, Alicia, ERB, Christopher, NANDI, Jayashree S, FOSTER, Gabriel J, AUTISSIER, Patrick, SCHMITZ, Jörn E

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Augmentation of Immune Responses to HIV-1 and Simian Immunodeficiency Virus DNA Vaccines by IL-2/Ig Plasmid Administration in Rhesus Monkeys by Barouch, Dan H., Craiu, Abie, Kuroda, Marcelo J., Schmitz, Jorn E., Zheng, Xin Xiao, Santra, Sampa, Frost, Julie D., Krivulka, Georgia R., Lifton, Michelle A., Crabbs, Carroll L., Heidecker, Gwendolyn, Perry, Helen C., Davies, Mary-Ellen, Xie, Hong, Nickerson, Christine E., Steenbeke, Tavis D., Lord, Carol I., Montefiori, David C., Strom, Terry B., Shiver, John W., Lewis, Mark G., Letvin, Norman L.

“…The potential utility of plasmid DNA as an HIV-1 vaccination modality currently is an area of active investigation. However, recent studies have raised doubts…”
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Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts by Silvestri, Guido, Sodora, Donald L, Allan, Jonathan S, Apetrei, Cristian, Brenchley, Jason M, Douek, Daniel C, Else, James G, Estes, Jacob D, Hahn, Beatrice H, Hirsch, Vanessa M, Kaur, Amitinder, Kirchhoff, Frank, Muller-Trutwin, Michaela, Pandrea, Ivona, Schmitz, Jörn E

“…The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine…”
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Recombinant Modified Vaccinia Virus Ankara-Simian Immunodeficiency Virus gag pol Elicits Cytotoxic T Lymphocytes in Rhesus Monkeys Detected by a Major Histocompatibility Complex Class I/Peptide Tetramer by Seth, Aruna, Ourmanov, Ilnour, Kuroda, Marcelo J., Schmitz, Jorn E., Carroll, Miles W., Wyatt, Linda S., Moss, Bernard, Forman, Meryl A., Hirsch, Vanessa M., Letvin, Norman L.

“…The utility of modified vaccinia virus Ankara (MVA) as a vector for eliciting AIDS virus-specific cytotoxic T lymphocytes (CTL) was explored in the simian…”
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Preserved CD4+ Central Memory T Cells and Survival in Vaccinated SIV-Challenged Monkeys by Letvin, Norman L, Mascola, John R, Sun, Yue, Gorgone, Darci A, Buzby, Adam P, Xu, Ling, Yang, Zhi-yong, Chakrabarti, Bimal, Rao, Srinivas S, Schmitz, Jörn E, Montefiori, David C, Barker, Brianne R, Bookstein, Fred L, Nabel, Gary J

“…Vaccine-induced cellular immunity controls virus replication in simian immunodeficiency virus (SIV)-infected monkeys only transiently, leading to the question…”
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KIR2DL4 Copy Number Variation Is Associated with CD4+ T-Cell Depletion and Function of Cytokine-Producing NK Cell Subsets in SIV-Infected Mamu-A01-Negative Rhesus Macaques by Hellmann, Ina, Letvin, Norman L, Schmitz, Jörn E

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Control of Viremia in Simian Immunodeficiency Virus Infection by CD8$^+$ Lymphocytes by Schmitz, Jörn E., Kuroda, Marcelo J., Santra, Sampa, Sasseville, Vito G., Simon, Meredith A., Lifton, Michelle A., Racz, Paul, Tenner-Racz, Klara, Dalesandro, Margaret, Scallon, Bernhard J., Ghrayeb, John, Forman, Meryl A., Montefiori, David C., Rieber, E. Peter, Letvin, Norman L., Reimann, Keith A.

“…Clinical evidence suggests that cellular immunity is involved in controlling human immunodeficiency virus-1 (HIV-1) replication. An animal model of acquired…”
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A Rationally Engineered Anti-HIV Peptide Fusion Inhibitor with Greatly Reduced Immunogenicity by BRAUER, Frances, SCHMIDT, Kerstin, ZAHN, Roland C, RICHTER, Cornelia, RADEKE, Heinfried H, SCHMITZ, Jorn E, VON LAER, Dorothee, EGERER, Lisa

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Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination by Barouch, Dan H., Santra, Sampa, Schmitz, Jörn E., Kuroda, Marcelo J., Fu, Tong-Ming, Wagner, Wendeline, Bilska, Miroslawa, Craiu, Abie, Zheng, Xin Xiao, Krivulka, Georgia R., Beaudry, Kristin, Lifton, Michelle A., Nickerson, Christine E., Trigona, Wendy L., Punt, Kara, Freed, Dan C., Guan, Liming, Dubey, Sheri, Casimiro, Danilo, Simon, Adam, Davies, Mary-Ellen, Chastain, Michael, Strom, Terry B., Gelman, Rebecca S., Montefiori, David C., Lewis, Mark G., Emini, Emilio A., Shiver, John W., Letvin, Norman L.

“…With accumulating evidence indicating the importance of cytotoxic T lymphocytes (CTLs) in containing human immunodeficiency virus-1 (HIV-1) replication in…”
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Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes by Barouch, Dan H, Kunstman, Jennifer, Kuroda, Marcelo J, Schmitz, Jörn E, Santra, Sampa, Peyerl, Fred W, Krivulka, Georgia R, Beaudry, Kristin, Lifton, Michelle A, Gorgone, Darci A, Montefiori, David C, Lewis, Mark G, Wolinsky, Steven M, Letvin, Norman L

“…Potent virus-specific cytotoxic T lymphocyte (CTL) responses elicited by candidate AIDS vaccines have recently been shown to control viral replication and…”
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Magnitude and Quality of Vaccine-Elicited T-Cell Responses in the Control of Immunodeficiency Virus Replication in Rhesus Monkeys by YUE SUN, SANTRA, Sampa, SCHMITZ, Jörn E, ROEDERER, Mario, LETVIN, Norman L

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Effect of CD8+ Lymphocyte Depletion on Virus Containment after Simian Immunodeficiency Virus SIVmac251 Challenge of Live Attenuated SIVmac239Δ3-Vaccinated Rhesus Macaques by SCHMITZ, Jörn E, JOHNSON, R. Paul, PIATAK, Michael, LIFSON, Jeffrey D, GROSSCHUPFF, Gudrun, RACZ, Paul, TENNER-RACZ, Klara, RIEBER, E. Peter, KUUS-REICHEL, Kristine, GELMAN, Rebecca S, LETVIN, Norman L, MONTEFIORI, David C, MCCLURE, Harold M, RUPRECHT, Ruth M, DESROSIERS, Ronald C, REIMANN, Keith A, MANSON, Kelledy H, WYAND, Michael S, KURODA, Marcelo J, LIFTON, Michelle A, KHUNKHUN, Rajinder S, MCEVERS, Kimberly J, GILLIS, Jacqueline

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Virus-Specific Cellular Immune Correlates of Survival in Vaccinated Monkeys after Simian Immunodeficiency Virus Challenge by YUE SUN, SCHMITZ, Jörn E, BUZBY, Adam P, BARKER, Brianne R, RAO, Srinivas S, LING XU, YANG, Zhi-Yong, MASCOLA, John R, NABEL, Gary J, LETVIN, Norman L

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Activating KIR Copy Number Variation Is Associated with Granzyme B Release by NK Cells during Primary Simian Immunodeficiency Virus Infection in Rhesus Monkeys by HELLMANN, Ina, SCHMITZ, Jörn E, LETVIN, Norman L

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Survival of the fittest: positive selection of CD4+ T cells expressing a membrane-bound fusion inhibitor following HIV-1 infection by Kimpel, Janine, Braun, Stephen E, Qiu, Gang, Wong, Fay Eng, Conolle, Michelle, Schmitz, Jörn E, Brendel, Christian, Humeau, Laurent M, Dropulic, Boro, Rossi, John J, Berger, Annemarie, von Laer, Dorothee, Johnson, R Paul

“…Although a variety of genetic strategies have been developed to inhibit HIV replication, few direct comparisons of the efficacy of these inhibitors have been…”
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Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys by Barouch, Dan H, Kunstman, Jennifer, Glowczwskie, Jennifer, Kunstman, Kevin J, Egan, Michael A, Peyerl, Fred W, Santra, Sampa, Kuroda, Marcelo J, Schmitz, Jörn E, Beaudry, Kristin, Krivulka, Georgia R, Lifton, Michelle A, Gorgone, Darci A, Wolinsky, Steven M, Letvin, Norman L

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Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys by Schmitz, Jörn E, Zahn, Roland C, Brown, Charles R, Rett, Melisa D, Li, Ming, Tang, Haili, Pryputniewicz, Sarah, Byrum, Russell A, Kaur, Amitinder, Montefiori, David C, Allan, Jonathan S, Goldstein, Simoy, Hirsch, Vanessa M

“…African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To…”
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Simian Immunodeficiency Virus (SIV)-Specific CD8+ T-Cell Responses in Vervet African Green Monkeys Chronically Infected with SIVagm by Zahn, Roland C, Rett, Melisa D, Korioth-Schmitz, Birgit, Sun, Yue, Buzby, Adam P, Goldstein, Simoy, Brown, Charles R, Byrum, Russell A, Freeman, Gordon J, Letvin, Norman L, Hirsch, Vanessa M, Schmitz, Jörn E

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Role of CD8+ Lymphocytes in Control and Clearance of Measles Virus Infection of Rhesus Monkeys by Permar, Sallie R, Klumpp, Sherry A, Mansfield, Keith G, Kim, Woong-Ki, Gorgone, Darci A, Lifton, Michelle A, Williams, Kenneth C, Schmitz, Jörn E, Reimann, Keith A, Axthelm, Michael K, Polack, Fernando P, Griffin, Diane E, Letvin, Norman L

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