Search Results - "Schmitt, Thomas M."

T Cells Engineered against a Native Antigen Can Surmount Immunologic and Physical Barriers to Treat Pancreatic Ductal Adenocarcinoma by Stromnes, Ingunn M., Schmitt, Thomas M., Hulbert, Ayaka, Brockenbrough, J. Scott, Nguyen, Hieu N., Cuevas, Carlos, Dotson, Ashley M., Tan, Xiaoxia, Hotes, Jennifer L., Greenberg, Philip D., Hingorani, Sunil R.

“…Pancreatic ductal adenocarcinomas (PDAs) erect physical barriers to chemotherapy and induce multiple mechanisms of immune suppression, creating a sanctuary for…”
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Perceptions of ecosystem services: Comparing socio-cultural and environmental influences by Thiemann, Miriam, Riebl, Rebekka, Haensel, Maria, Schmitt, Thomas M, Steinbauer, Manuel J, Landwehr, Theresa, Fricke, Ute, Redlich, Sarah, Koellner, Thomas

“…Ecosystem services such as food provisioning, climate regulation, nutrient cycling, or recreation in open landscapes underpin human wellbeing. They are highly…”
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Plural valuation in space: mapping values of grasslands and their ecosystem services by Schmitt, Thomas M., Riebl, Rebekka, Martín-López, Berta, Hänsel, Maria, Koellner, Thomas

“…The agricultural management of grasslands not only is strongly linked to fodder production but also provides other valuable ecosystem services such as carbon…”
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Where and why is landscape considered valuable? Societal actors' perceptions of ecosystem services across Bavaria (Germany) by Küchen, Lisa, Schmitt, Thomas M., Riebl, Rebekka, Hänsel, Maria, Steinbauer, Manuel J., Fricke, Ute, Redlich, Sarah, Koellner, Thomas

“…Balancing the demand for ecosystem services (ES) with available supply is one key challenge for decision making in sustainable landscape management. ES demand…”
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Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis by Chour, William, Choi, Jongchan, Xie, Jingyi, Chaffee, Mary E., Schmitt, Thomas M., Finton, Kathryn, DeLucia, Diana C., Xu, Alexander M., Su, Yapeng, Chen, Daniel G., Zhang, Rongyu, Yuan, Dan, Hong, Sunga, Ng, Alphonsus H. C., Butler, Jonah Z., Edmark, Rick A., Jones, Lesley C., Murray, Kim M., Peng, Songming, Li, Guideng, Strong, Roland K., Lee, John K., Goldman, Jason D., Greenberg, Philip D., Heath, James R.

“…The discovery and characterization of antigen-specific CD8 + T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC…”
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Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation by Ciofani, Maria, Schmitt, Thomas M, Ciofani, Amelia, Michie, Alison M, Cuburu, Nicolas, Aublin, Anne, Maryanski, Janet L, Zuniga-Pflucker, Juan Carlos

“…The first checkpoint during T cell development, known as beta selection, requires the successful rearrangement of the TCR-beta gene locus. Notch signaling has…”
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Improving Agri-environmental Schemes: Suggestions from Farmers and Nature Managers in a Central European Region by Zindler, Manuela, Haensel, Maria, Fricke, Ute, Schmitt, Thomas M., Tobisch, Cynthia, Koellner, Thomas

“…Agri-environmental schemes (AES) are important policy instruments within the Common Agricultural Policy (CAP) of the European Union for environmental…”
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(Why) did Desertec fail? An interim analysis of a large-scale renewable energy infrastructure project from a Social Studies of Technology perspective by Schmitt, Thomas M.

“…In 2009 the Desertec Industrial Initiative (DII) was founded by several, predominant German enterprises. The objective of DII was to organise the conditions…”
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Teaching the Modeling of Human–Environment Systems: Acknowledging Complexity with an Agent-Based Model by Haensel, Maria, Schmitt, Thomas M., Bogenreuther, Jakob

“…Agent-based modeling is a promising tool for familiarizing students with complex systems as well as programming skills. Human–environment systems, for…”
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T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant by Chapuis, Aude G., Egan, Daniel N., Bar, Merav, Schmitt, Thomas M., McAfee, Megan S., Paulson, Kelly G., Voillet, Valentin, Gottardo, Raphael, Ragnarsson, Gunnar B., Bleakley, Marie, Yeung, Cecilia C., Muhlhauser, Petri, Nguyen, Hieu N., Kropp, Lara A., Castelli, Luca, Wagener, Felecia, Hunter, Daniel, Lindberg, Marcus, Cohen, Kristen, Seese, Aaron, McElrath, M. Juliana, Duerkopp, Natalie, Gooley, Ted A., Greenberg, Philip D.

“…Relapse after allogeneic hematopoietic cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) entering HCT with…”
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Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains by Harris, Daniel T, Hager, Marlies V, Smith, Sheena N, Cai, Qi, Stone, Jennifer D, Kruger, Philipp, Lever, Melissa, Dushek, Omer, Schmitt, Thomas M, Greenberg, Philip D, Kranz, David M

“…Adoptive T cell therapies have achieved significant clinical responses, especially in hematopoietic cancers. Two types of receptor systems have been used to…”
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A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia by Oda, Shannon K., Daman, Andrew W., Garcia, Nicolas M., Wagener, Felecia, Schmitt, Thomas M., Tan, Xiaoxia, Chapuis, Aude G., Greenberg, Philip D.

“…Acute myeloid leukemia (AML), the most common adult acute leukemia in the United States, has the poorest survival rate, with 26% of patients surviving 5 years…”
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Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro by Schmitt, Thomas M, Aggen, David H, Ishida-Tsubota, Kumiko, Ochsenreither, Sebastian, Kranz, David M, Greenberg, Philip D

“…The affinity of T cells for tumor self-antigens is improved by a culture system that identifies optimal T-cell-receptor B chains. Many promising targets for…”
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The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor by Hudecek, Michael, Schmitt, Thomas M., Baskar, Sivasubramanian, Lupo-Stanghellini, Maria Teresa, Nishida, Tetsuya, Yamamoto, Tori N., Bleakley, Marie, Turtle, Cameron J., Chang, Wen-Chung, Greisman, Harvey A., Wood, Brent, Maloney, David G., Jensen, Michael C., Rader, Christoph, Riddell, Stanley R.

“…Monoclonal antibodies and T cells modified to express chimeric antigen receptors specific for B-cell lineage surface molecules such as CD20 exert antitumor…”
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Induction of T Cell Development from Hematopoietic Progenitor Cells by Delta-like-1 In Vitro by Schmitt, Thomas M., Zúñiga-Pflücker, Juan Carlos

“…The molecular interactions provided by the thymic microenvironment that predicate T cell development remain obscure. Here, we show that a bone marrow stromal…”
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Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients by Chapuis, Aude G, Ragnarsson, Gunnar B, Nguyen, Hieu N, Chaney, Colette N, Pufnock, Jeffrey S, Schmitt, Thomas M, Duerkopp, Natalie, Roberts, Ilana M, Pogosov, Galina L, Ho, William Y, Ochsenreither, Sebastian, Wölfl, Matthias, Bar, Merav, Radich, Jerald P, Yee, Cassian, Greenberg, Philip D

“…Relapse remains a leading cause of death after allogeneic hematopoietic cell transplantation (HCT) for patients with high-risk leukemias. The potentially…”
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New Strategies in Engineering T-cell Receptor Gene-Modified T cells to More Effectively Target Malignancies by Schmitt, Thomas M, Stromnes, Ingunn M, Chapuis, Aude G, Greenberg, Philip D

“…The immune system, T cells in particular, have the ability to target and destroy malignant cells. However, antitumor immune responses induced from the…”
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Re-adapting T cells for cancer therapy: from mouse models to clinical trials by Stromnes, Ingunn M., Schmitt, Thomas M., Chapuis, Aude G., Hingorani, Sunil R., Greenberg, Philip D.

“…Summary Adoptive T‐cell therapy involves the isolation, expansion, and reinfusion of T lymphocytes with a defined specificity and function as a means to…”
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Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency by Lahman, Miranda C, Schmitt, Thomas M, Paulson, Kelly G, Vigneron, Nathalie, Buenrostro, Denise, Wagener, Felecia D, Voillet, Valentin, Martin, Lauren, Gottardo, Raphael, Bielas, Jason, McElrath, Julie M, Stirewalt, Derek L, Pogosova-Agadjanyan, Era L, Yeung, Cecilia C, Pierce, Robert H, Egan, Daniel N, Bar, Merav, Hendrie, Paul C, Kinsella, Sinéad, Vakil, Aesha, Butler, Jonah, Chaffee, Mary, Linton, Jonathan, McAfee, Megan S, Hunter, Daniel S, Bleakley, Marie, Rongvaux, Anthony, Van den Eynde, Benoit J, Chapuis, Aude G, Greenberg, Philip D

“…Designing effective antileukemic immunotherapy will require understanding mechanisms underlying tumor control or resistance. Here, we report a mechanism of…”
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T cell receptor gene therapy for cancer by Schmitt, Thomas M, Ragnarsson, Gunnar B, Greenberg, Philip D

“…T cell-based adoptive immunotherapy has been shown to be a promising treatment for various types of cancer. However, adoptive T cell therapy currently requires…”
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