Search Results - "Schmitt, Julie"
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Design and Synthesis of a Trifunctional Molecular System “Programmed” to Block Epidermal Growth Factor Receptor Tyrosine Kinase, Induce High Levels of DNA Damage, and Inhibit the DNA Repair Enzyme (Poly(ADP-ribose) Polymerase) in Prostate Cancer Cells
Published in Journal of medicinal chemistry (11-06-2020)Get full text
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Molecular Analysis of the Superior Efficacy of a Dual Epidermal Growth Factor Receptor (EGFR)-DNA-Targeting Combi-Molecule in Comparison with Its Putative Prodrugs 6-Mono-Alkylamino- and 6,6-Dialkylaminoquinazoline in a Human Osteosarcoma Xenograft Model
Published in Cells (Basel, Switzerland) (01-03-2023)“…: ZR2002 is a dual EGFR-DNA-targeting combi-molecule that carries a chloroethyl group at the six-position of the quinazoline ring designed to alkylate DNA…”
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Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy
Published in Angewandte Chemie International Edition (02-01-2015)“…Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and…”
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Disruption of Intracellular Metal Homeostasis As a Vulnerability in SF3B1 Mutated AML
Published in Blood (15-11-2022)Get full text
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Mechanisms and Antitumor Activity of a Binary EGFR/DNA-Targeting Strategy Overcomes Resistance of Glioblastoma Stem Cells to Temozolomide
Published in Clinical cancer research (15-12-2019)“…Glioblastoma (GBM) is a fatal primary malignant brain tumor. GBM stem cells (GSC) contribute to resistance to the DNA-damaging chemotherapy, temozolomide. The…”
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A Theranostic Agent Combining a Two-Photon-Absorbing Photosensitizer for Photodynamic Therapy and a Gadolinium(III) Complex for MRI Detection
Published in Chemistry : a European journal (18-02-2016)“…The convergent synthesis and characterization of a potential theranostic agent, [DPP‐ZnP‐GdDOTA]−, which combines a diketopyrrolopyrrole‐porphyrin component…”
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A Porphyrin Dimer–GdDOTA Conjugate as a Theranostic Agent for One- and Two-Photon Photodynamic Therapy and MRI
Published in Bioconjugate chemistry (21-11-2018)“…A molecular theranostic agent designed for photodynamic therapy (PDT) treatment in the near-infrared and for imaging tissue tumors with magnetic resonance…”
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Four Gadolinium(III) Complexes Appended to a Porphyrin: A Water-Soluble Molecular Theranostic Agent with Remarkable Relaxivity Suited for MRI Tracking of the Photosensitizer
Published in Inorganic chemistry (02-05-2016)“…A molecular theranostic agent for magnetic resonance imaging (MRI) and photodynamic therapy (PDT) consisting of four [GdDTTA]− complexes (DTTA4− =…”
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Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules
Published in European journal of medicinal chemistry (15-04-2020)“…Over the past decade, we described a novel tumour targeted approach that sought to design “combi-molecules” to hit two distinct targets in tumour cells. Here,…”
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π-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers
Published in Supramolecular chemistry (02-11-2017)“…A Zn-porphyrin dimer and its linear conjugate with two diketopyrrolopyrrole (DPP) units have been prepared and their one- and two-photon photophysical…”
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[pi]-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers
Published in Supramolecular chemistry (01-11-2017)“…A Zn-porphyrin dimer and its linear conjugate with two diketopyrrolopyrrole (DPP) units have been prepared and their one- and two-photon photophysical…”
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SF3B1 mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia
Published in Science advances (22-03-2024)“…In a phenotypical screen of 56 acute myeloid leukemia (AML) patient samples and using a library of 10,000 compounds, we identified a hit with increased…”
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Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy
Published in Angewandte Chemie (02-01-2015)“…Two‐photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two‐photon absorption and…”
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14
Trusting your gut. An employee's suspicious behavior teaches a doctor the value of following her instincts
Published in Medical economics (19-11-2010)Get more information
Magazine Article -
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Investigating career counseling and the false dichotomy hypothesis: A systematic case study approach to process research
Published 01-01-2003“…Despite numerous calls by researchers and scholars in the field of counseling psychology, few attempts to examine the underlying elements of the career…”
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Dissertation