Search Results - "Schmitt, Heather M"

Genetic background determines severity of Loxl1-mediated systemic and ocular elastosis in mice by Suarez, Maria F, Schmitt, Heather M, Kuhn, Megan S, Watkins, TeddiJo, Hake, Kristyn M, Weisz, Tara, Flynn, 3rd, Edward J, Elliott, Michael H, Hauser, Michael A, Stamer, W Daniel

“…Pseudoexfoliation syndrome (PEX) is a systemic, age-related disorder characterized by elastosis and extracellular matrix deposits. Its most significant ocular…”
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Targeting HDAC3 in the DBA/2J spontaneous mouse model of glaucoma by Schmitt, Heather M., Grosser, Joshua A., Schlamp, Cassandra L., Nickells, Robert W.

“…High intraocular pressure (IOP) is the most common risk factor associated with glaucoma in humans. While lowering IOP is effective at reducing the rate of…”
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Role of HDACs in optic nerve damage-induced nuclear atrophy of retinal ganglion cells by Schmitt, Heather M., Schlamp, Cassandra L., Nickells, Robert W.

“…•HDACs 1, 2, and 3 play major roles in retinal ganglion cell (RGC) death.•Nuclear atrophy is associated with increased HDAC activity in RGCs.•HDAC3 is…”
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AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury by Nickells, Robert W, Schmitt, Heather M, Maes, Margaret E, Schlamp, Cassandra L

“…Gene therapy of retinal ganglion cells (RGCs) has promise as a powerful therapeutic for the rescue and regeneration of these cells after optic nerve damage…”
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Lysyl oxidase-like 1-antisense 1 (LOXL1-AS1) lncRNA differentially regulates gene and protein expression, signaling and morphology of human ocular cells by Schmitt, Heather M, Hake, Kristyn M, Perkumas, Kristin M, Lê, Brandon M, Suarez, Maria F, De Ieso, Michael L, Rahman, Rashad S, Johnson, William M, Gomez-Caraballo, María, Ashley-Koch, Allison E, Hauser, Michael A, Stamer, W Daniel

“…Pseudoexfoliation glaucoma (PEXG) is characterized by dysregulated extracellular matrix (ECM) homeostasis that disrupts conventional outflow function and…”
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Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression by Schmitt, Heather M., Fehrman, Rachel L., Maes, Margaret E., Yang, Huan, Guo, Lian-Wang, Schlamp, Cassandra L., Pelzel, Heather R., Nickells, Robert W.

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Identification and activity of the functional complex between hnRNPL and the pseudoexfoliation syndrome-associated lncRNA, LOXL1-AS1 by Schmitt, Heather M, Johnson, William M, Aboobakar, Inas F, Strickland, Shelby, Gomez-Caraballo, María, Parker, Megan, Finnegan, Laura, Corcoran, David L, Skiba, Nikolai P, Allingham, R Rand, Hauser, Michael A, Stamer, W Daniel

“…Abstract Individuals with pseudoexfoliation (PEX) syndrome exhibit various connective tissue pathologies associated with dysregulated extracellular matrix…”
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Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury by Schmitt, Heather M, Pelzel, Heather R, Schlamp, Cassandra L, Nickells, Robert W

“…Optic nerve damage initiates a series of early atrophic events in retinal ganglion cells (RGCs) that precede the BAX-dependent committed step of the intrinsic…”
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Preservation of Murine Whole Eyes With Supplemented UW Cold Storage Solution: Anatomical Considerations by Muench, Nicole A., Schmitt, Heather M., Schlamp, Cassandra L., Su, An-Jey A., Washington, Kia, Nickells, Robert W.

“…Retinal ganglion cell (RGC) apoptosis and axon regeneration are the principal obstacles challenging the development of successful whole eye transplantation…”
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Role of Histone Deacetylase-3 (HDAC3) in Retinal Ganglion Cell Death by Schmitt, Heather M

“…Glaucoma is a leading cause of blindness in the developed world, and it is characterized by retinal ganglion cell (RGC) death in response to axonal injury at…”
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