Search Results - "Schmitt, Esther"

High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine by Straimer, Judith, Gandhi, Preetam, Renner, Katalin Csermak, Schmitt, Esther K

“…Abstract In Southeast Asia, mutations in the Plasmodium falciparum K13 gene have led to delayed parasite clearance and treatment failures in patients with…”
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Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation by Wlodarska, Marta, Luo, Chengwei, Kolde, Raivo, d’Hennezel, Eva, Annand, John W., Heim, Cortney E., Krastel, Philipp, Schmitt, Esther K., Omar, Abdifatah S., Creasey, Elizabeth A., Garner, Ashley L., Mohammadi, Sina, O’Connell, Daniel J., Abubucker, Sahar, Arthur, Timothy D., Franzosa, Eric A., Huttenhower, Curtis, Murphy, Leon O., Haiser, Henry J., Vlamakis, Hera, Porter, Jeffrey A., Xavier, Ramnik J.

“…Host factors in the intestine help select for bacteria that promote health. Certain commensals can utilize mucins as an energy source, thus promoting their…”
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Triclabendazole in the treatment of human fascioliasis: a review by Gandhi, Preetam, Schmitt, Esther K, Chen, Chien-Wei, Samantray, Sanjay, Venishetty, Vinay Kumar, Hughes, David

“…Fascioliasis occurs on all inhabited continents. It is caused by Fasciola hepatica and Fasciola gigantica, trematode parasites with complex life cycles, and…”
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Efficacy of Cipargamin (KAE609) in a Randomized, Phase II Dose-Escalation Study in Adults in Sub-Saharan Africa With Uncomplicated Plasmodium falciparum Malaria by Schmitt, Esther K, Ndayisaba, Gilles, Yeka, Adoke, Asante, Kwaku Poku, Grobusch, Martin P, Karita, Etienne, Mugerwa, Henry, Asiimwe, Stephen, Oduro, Abraham, Fofana, Bakary, Doumbia, Seydou, Su, Guoqin, Csermak Renner, Katalin, Venishetty, Vinay Kumar, Sayyed, Sarfaraz, Straimer, Judith, Demin, Ivan, Barsainya, Sarita, Boulton, Caroline, Gandhi, Preetam

“…Abstract Background Cipargamin (KAE609) is a potent antimalarial in a phase II trial. Here we report efficacy, pharmacokinetics, and resistance marker analysis…”
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Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin by Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.

“…With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver-…”
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Nannocystin A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties by Krastel, Philipp, Roggo, Silvio, Schirle, Markus, Ross, Nathan T., Perruccio, Francesca, Aspesi Jr, Peter, Aust, Thomas, Buntin, Kathrin, Estoppey, David, Liechty, Brigitta, Mapa, Felipa, Memmert, Klaus, Miller, Howard, Pan, Xuewen, Riedl, Ralph, Thibaut, Christian, Thomas, Jason, Wagner, Trixie, Weber, Eric, Xie, Xiaobing, Schmitt, Esther K., Hoepfner, Dominic

“…Cultivation of myxobacteria of the Nannocystis genus led to the isolation and structure elucidation of a class of novel cyclic lactone inhibitors of elongation…”
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Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria by Yeung, Bryan K. S, Zou, Bin, Rottmann, Matthias, Lakshminarayana, Suresh B, Ang, Shi Hua, Leong, Seh Yong, Tan, Jocelyn, Wong, Josephine, Keller-Maerki, Sonja, Fischli, Christoph, Goh, Anne, Schmitt, Esther K, Krastel, Philipp, Francotte, Eric, Kuhen, Kelli, Plouffe, David, Henson, Kerstin, Wagner, Trixie, Winzeler, Elizabeth A, Petersen, Frank, Brun, Reto, Dartois, Veronique, Diagana, Thierry T, Keller, Thomas H

“…The antiplasmodial activity of a series of spirotetrahydro β-carbolines is described. Racemic spiroazepineindole (1) was identified from a phenotypic screen on…”
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The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease by Schmitt, Esther K., Riwanto, Meliana, Sambandamurthy, Vasan, Roggo, Silvio, Miault, Charlotte, Zwingelstein, Christian, Krastel, Philipp, Noble, Christian, Beer, David, Rao, Srinivasa P. S., Au, Melvin, Niyomrattanakit, Pornwaratt, Lim, Viviam, Zheng, Jun, Jeffery, Douglas, Pethe, Kevin, Camacho, Luis R.

“…Target practice: The target of the antibiotic cyclomarin A was identified in Mycobacterium. Cyclomarin A (see structure) binds the regulatory subunit of the…”
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The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound by Bouwman, Suzan AM, Zoleko-Manego, Rella, Renner, Katalin Csermak, Schmitt, Esther K., Mombo-Ngoma, Ghyslain, Grobusch, Martin P.

“…Cipargamin (KAE609) is a novel spiroindolone class drug for the treatment of malaria, currently undergoing phase 2 clinical development. This review provides…”
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Natural products as probes in pharmaceutical research by Schmitt, Esther K, Hoepfner, D, Krastel, P

“…From the start of the pharmaceutical research natural products played a key role in drug discovery and development. Over time many discoveries of fundamental…”
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Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa by Ndayisaba, Gilles, Yeka, Adoke, Asante, Kwaku Poku, Grobusch, Martin P, Karita, Etienne, Mugerwa, Henry, Asiimwe, Stephen, Oduro, Abraham, Fofana, Bakary, Doumbia, Seydou, Jain, Jay Prakash, Barsainya, Sarita, Kullak-Ublick, Gerd A, Su, Guoqin, Schmitt, Esther K, Csermak, Katalin, Gandhi, Preetam, Hughes, David

“…The novel anti-malarial cipargamin (KAE609) has potent, rapid activity against Plasmodium falciparum. Transient asymptomatic liver function test elevations…”
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Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu by Morris, Rowan P, Leeds, Jennifer A, Naegeli, Hans Ulrich, Oberer, Lukas, Memmert, Klaus, Weber, Eric, LaMarche, Matthew J, Parker, Christian N, Burrer, Nathalie, Esterow, Stacey, Hein, Andreas E, Schmitt, Esther K, Krastel, Philipp

“…We identified the thiomuracins, a novel family of thiopeptides produced by a rare-actinomycete bacterium typed as a Nonomuraea species, via a screen for…”
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Natural products as catalysts for innovation: a pharmaceutical industry perspective by Schmitt, Esther K, Moore, Charles M, Krastel, Philipp, Petersen, Frank

“…Natural products are evolutionarily designed and chemically distinct from most synthetic library molecules. In addition to their role as drugs, they are…”
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Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo by Gandhirajan, Rajesh Kumar, Staib, Peter Anton, Minke, Katharina, Gehrke, Iris, Plickert, Günther, Schlösser, Axel, Schmitt, Esther Katharina, Hallek, Michael, Kreuzer, Karl-Anton

“…BACKGROUND: Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes…”
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Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin by Rusch, Marion, Thevenon, Arnaud, Hoepfner, Dominic, Aust, Thomas, Studer, Christian, Patoor, Maude, Rollin, Patrick, Livendahl, Madeleine, Ranieri, Beatrice, Schmitt, Esther, Spanka, Carsten, Gademann, Karl, Bouchez, Laure C.

“…Selective and specific inhibitors of Plasmodium falciparum lysyl‐tRNA synthetase represent promising therapeutic antimalarial avenues. Cladosporin was…”
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Gift from Nature: Cyclomarin A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action by Bürstner, Nathalie, Roggo, Silvio, Ostermann, Nils, Blank, Jutta, Delmas, Cecile, Freuler, Felix, Gerhartz, Bernd, Hinniger, Alexandra, Hoepfner, Dominic, Liechty, Brigitta, Mihalic, Manuel, Murphy, Jason, Pistorius, Dominik, Rottmann, Matthias, Thomas, Jason R., Schirle, Markus, Schmitt, Esther K.

“…Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical…”
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Luteipulveratus halotolerans sp. nov., an actinobacterium (Dermacoccaceae) from forest soil by Juboi, Holed, Basik, Ann Anni, Shamsul, Sunita Sara Gill, Arnold, Phil, Schmitt, Esther K, Sanglier, Jean-Jacques, Yeo, Tiong Chia

“…The taxonomic position of an actinobacterium strain, C296001T, isolated from a soil sample collected in Sarawak, Malaysia, was established using a polyphasic…”
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Spiroindolones, a Potent Compound Class for the Treatment of Malaria by Rottmann, Matthias, McNamara, Case, Yeung, Bryan K.S, Lee, Marcus C.S, Zou, Bin, Russell, Bruce, Seitz, Patrick, Plouffe, David M, Dharia, Neekesh V, Tan, Jocelyn, Cohen, Steven B, Spencer, Kathryn R, González-Páez, Gonzalo E, Lakshminarayana, Suresh B, Goh, Anne, Suwanarusk, Rossarin, Jegla, Timothy, Schmitt, Esther K, Beck, Hans-Peter, Brun, Reto, Nosten, Francois, Renia, Laurent, Dartois, Veronique, Keller, Thomas H, Fidock, David A, Winzeler, Elizabeth A, Diagana, Thierry T

“…Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments…”
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Antibacterial and Solubility Optimization of Thiomuracin A by LaMarche, Matthew J, Leeds, Jennifer A, Brewer, Jason, Dean, Karl, Ding, Jian, Dzink-Fox, Joanne, Gamber, Gabe, Jain, Akash, Kerrigan, Ryan, Krastel, Philipp, Lee, Kwangho, Lombardo, Franco, McKenney, David, Neckermann, Georg, Osborne, Colin, Palestrant, Deborah, Patane, Michael A, Rann, Elin M, Robinson, Zachary, Schmitt, Esther, Stams, Travis, Tiamfook, Stacey, Yu, Donghui, Whitehead, Lewis

“…Synthetic studies of the antimicrobial secondary metabolite thiomuracin A (1) provided access to analogues in the Northern region (C2–C10). Selective…”
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A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin by Qiu, Deyun, Pei, Jinxin V., Rosling, James E. O., Thathy, Vandana, Li, Dongdi, Xue, Yi, Tanner, John D., Penington, Jocelyn Sietsma, Aw, Yi Tong Vincent, Aw, Jessica Yi Han, Xu, Guoyue, Tripathi, Abhai K., Gnadig, Nina F., Yeo, Tomas, Fairhurst, Kate J., Stokes, Barbara H., Murithi, James M., Kümpornsin, Krittikorn, Hasemer, Heath, Dennis, Adelaide S. M., Ridgway, Melanie C., Schmitt, Esther K., Straimer, Judith, Papenfuss, Anthony T., Lee, Marcus C. S., Corry, Ben, Sinnis, Photini, Fidock, David A., van Dooren, Giel G., Kirk, Kiaran, Lehane, Adele M.

“…Diverse compounds target the Plasmodium falciparum Na + pump PfATP4, with cipargamin and (+)-SJ733 the most clinically-advanced. In a recent clinical trial for…”
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