Search Results - "Schmitt, Eberhard"
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PML promotes MHC class II gene expression by stabilizing the class II transactivator
Published in The Journal of cell biology (01-10-2012)“…Promyelocytic leukemia (PML) nuclear bodies selectively associate with transcriptionally active genomic regions, including the gene-rich major…”
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In-silico modeling of the mitotic spindle assembly checkpoint
Published in PloS one (06-02-2008)“…The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism that ensures the correct segregation of chromosomes by restraining cell…”
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Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited
Published in Journal of neurology (01-06-2007)“…AbstractBackgroundSeveral case reports have linked iron deficiency anemia with the occurrence of cerebral venous thrombosis (CVT) or stroke, yet, it is unclear…”
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COMBO-FISH enables high precision localization microscopy as a prerequisite for nanostructure analysis of genome loci
Published in International journal of molecular sciences (21-10-2010)“…With the completeness of genome databases, it has become possible to develop a novel FISH (Fluorescence in Situ Hybridization) technique called COMBO-FISH…”
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Spinocerebellar ataxia 14: Novel mutation in exon 2 of PRKCG in a German family
Published in Movement disorders (15-01-2007)“…We describe a novel mutation in the gene coding for protein kinase C gamma (PRKCG) in patients of a German family affected with slowly progressive gait ataxia,…”
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Nuclear position and shape deformation of chromosome 8 territories in pancreatic ductal adenocarcinoma
Published in Analytical cellular pathology (Amsterdam) (01-01-2011)“…Cell type specific radial positioning of chromosome territories (CTs) and their sub-domains in the interphase seem to have functional relevance in…”
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COMBO-FISH: specific labeling of nondenatured chromatin targets by computer-selected DNA oligonucleotide probe combinations
Published in BioTechniques (01-09-2003)“…Here we present the principle of fluorescence in situ hybridization (FISH) with combinatorial oligonucleotide (COMBO) probes as a new approach for the specific…”
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Stochastic effects in a compartmental model for mitotic checkpoint regulation
Published in Journal of integrative bioinformatics (01-12-2007)“…The proper segregation of sister chromatids at onset of anaphase is surveyed by the mitotic spindle assembly checkpoint. The concentration dynamics of the…”
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Risk of Ischemic Stroke and Transient Ischemic Attack Is Increased up to 90 Days after Non-Carotid and Non-Cardiac Surgery
Published in Cerebrovascular diseases (Basel, Switzerland) (01-06-2017)“…The risk of stroke after cardiac and carotid surgery is well established. In contrast, stroke risk in association with non-cardiac and non-carotid surgery and…”
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Localization Microscopy Analyses of MRE11 Clusters in 3D-Conserved Cell Nuclei of Different Cell Lines
Published in Cancers (22-01-2018)“…In radiation biophysics, it is a subject of nowadays research to investigate DNA strand break repair in detail after damage induction by ionizing radiation. It…”
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Adjuvant autologous renal tumour cell vaccine and risk of tumour progression in patients with renal-cell carcinoma after radical nephrectomy: phase III, randomised controlled trial
Published in The Lancet (British edition) (21-02-2004)“…Organ-confined renal-cell carcinoma is associated with tumour progression in up to 50% of patients after radical nephrectomy. At present, no effective adjuvant…”
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Volume increase and spatial shifts of chromosome territories in nuclei of radiation-induced polyploidizing tumour cells
Published in Mutation research (30-08-2013)“…The exposure of tumour cells to high doses of ionizing radiation can induce endopolyploidization as an escape route from cell death. This strategy generally…”
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PNA-COMBO-FISH: From combinatorial probe design in silico to vitality compatible, specific labelling of gene targets in cell nuclei
Published in Experimental cell research (01-07-2016)“…Recently, advantages concerning targeting specificity of PCR constructed oligonucleotide FISH probes in contrast to established FISH probes, e.g. BAC clones,…”
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Mad2 binding is not sufficient for complete Cdc20 sequestering in mitotic transition control (an in silico study)
Published in Biophysical chemistry (01-04-2008)“…For successful mitosis, metaphase has to be arrested until all centromeres are properly attached. The onset of anaphase, which is initiated by activating the…”
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Combinatorial selection of short triplex forming oligonucleotides for fluorescence in situ hybridisation COMBO-FISH
Published in Journal of computational science (01-09-2012)“…For the selection of short triplex forming oligonucleotides for COMBO-FISH hybridisations used in research and medicine for 3D-structure investigations of the…”
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Anemia as a risk factor for cerebral venous thrombosis? : An old hypothesis revisited results of a prospective study
Published in Journal of neurology (01-06-2007)“…Several case reports have linked iron deficiency anemia with the occurrence of cerebral venous thrombosis (CVT) or stroke, yet, it is unclear whether this is a…”
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In silico study of kinetochore control, amplification, and inhibition effects in MCC assembly
Published in BioSystems (2009)“…Eukaryotic cells rely on a surveillance mechanism, the “Spindle Assembly Checkpoint” SAC M in order to ensure accurate chromosome segregation by preventing…”
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Quality Monitoring of Acute Stroke Care in Rhineland-Palatinate, Germany, 2001―2006
Published in Stroke (1970) (01-07-2010)“…Quality monitoring projects are useful tools to improve the quality and to assess temporal trends of stroke care in larger populations. In…”
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