Search Results - "Schmieden, V."

Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors by Laube, B, Kuhse, J, Rundström, N, Kirsch, J, Schmieden, V, Betz, H

“…1. The effect of the divalent cation Zn2+ on inhibitory glycine receptor (GlyR) currents was investigated in rat embryonic spinal cord neurons and Xenopus…”
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Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation by Schmieden, V., Kuhse, J., Betz, H.

“…The inhibitory glycine receptor (GlyR) is a pentameric chloride channel protein which mediates postsynaptic inhibition in the mammalian central nervous system…”
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Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia by Langosch, D., Laube, B., Rundström, N., Schmieden, V., Bormann, J., Betz, H.

“…Hereditary hyperekplexia is a dominant neurological disorder associated with point mutations at the channel‐forming segment M2 of the glycine receptor alpha 1…”
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Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds by Schmieden, V, Betz, H

“…To define structure-activity relations for ligands binding to the inhibitory glycine receptor (GlyR), the agonistic and antagonistic properties of alpha- and…”
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Identification and functional expression of a novel ligand binding subunit of the inhibitory glycine receptor by Kuhse, J, Schmieden, V, Betz, H

“…By homology screening of a rat brain cDNA library we have identified a novel alpha subunit variant of the inhibitory glycine receptor, alpha 3. The deduced…”
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Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes by Grenningloh, G., Schmieden, V., Schofield, P.R., Seeburg, P.H., Siddique, T., Mohandas, T.K., Becker, C.M., Betz, H.

“…Two cDNAs encoding variants (alpha 1 and alpha 2) of the strychnine binding subunit of the inhibitory glycine receptor (GlyR) were isolated from a human fetal…”
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Functional expression in Xenopus oocytes of the strychnine binding 48 kd subunit of the glycine receptor by Schmieden, V., Grenningloh, G., Schofield, P. R., Betz, H.

“…The inhibitory postsynaptic glycine receptor (GlyR) of rat spinal cord is an oligomeric transmembrane protein which forms an agonist‐gated anion channel…”
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Alternative splicing generates two isoforms of the α2 subunit of the inhibitory glycine receptor by Kuhse, J., Kuryatov, A., Maulet, Y., Malosio, M.L., Schmieden, V., Betz, H.

“…The inhibitory glycine receptor (GlyR) is a ligand-gated chloride channel protein which displays developmental heterogeneity in the mammalian central nervous…”
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Cyanotriphenylborate: Subtype-Specific Blocker of Glycine Receptor Chloride Channels by Rundstrom, Nils, Schmieden, Volker, Betz, Heinrich, Bormann, Joachim, Langosch, Dieter

“…The inhibitory glycine receptor is a ligandgated ion-channel protein existing in different homo- and heterooligomeric isoforms. Here we show that the chloride…”
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Novel antagonists of the inhibitory glycine receptor derived from quinolinic acid compounds by Schmieden, V, Jezequel, S, Betz, H

“…Binding of the coagonist glycine to the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors is potently antagonized by 2-carboxy-4-hydroxyquinolines. We…”
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Structure and biology of inhibitory glycine receptors by Betz, H, Langosch, D, Rundström, N, Bormann, J, Kuryatov, A, Kuhse, J, Schmieden, V, Matzenbach, B, Kirsch, J

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Structure, diversity and synaptic localization of inhibitory glycine receptors by Betz, H, Kuhse, J, Fischer, M, Schmieden, V, Laube, B, Kuryatov, A, Langosch, D, Meyer, G, Bormann, J, Rundström, N

“…The inhibitory glycine receptor (GlyR) mediates postsynaptic inhibition in spinal cord, brain stem and other regions of the vertebrate central nervous system…”
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Inhibition of [alpha]-subunit glycine receptors by quinoxallnes by Meier, J, Schmieden, V

“…Quinoxalines are widely used compounds in electrophysiological studies to separate excitatory and inhibitory neurotransmission mediated by the…”
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How to build a glycinergic postsynaptic membrane by BETZ, H, KUHSE, J, SCHMIEDEN, V, MALOSIO, M.-L, LANGOSCH, D, PRIOR, P, SCHMITT, B, KIRSCH, J

“…The inhibitory glycine receptor (GlyR) is a ligand-gated chloride channel protein found at many synapses of the mammalian central nervous system. During…”
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Heterogeneity of the inhibitory glycine receptor by Kuhse, J, Becker, C M, Schmieden, V, Hoch, W, Pribilla, I, Langosch, D, Malosio, M L, Muntz, M, Betz, H

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Alternative splicing generates two variants of the alpha 1 subunit of the inhibitory glycine receptor by Malosio, M L, Grenningloh, G, Kuhse, J, Schmieden, V, Schmitt, B, Prior, P, Betz, H

“…The inhibitory glycine receptor (GlyR) in mammalian spinal cord displays pharmacological and molecular heterogeneity of its strychnine binding alpha subunit…”
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Structure and Functions of Inhibitory and Excitatory Glycine Receptors by BETZ, HEINRICH, KUHSE, JOCHEN, SCHMIEDEN, VOLKER, LAUBE, BODO, KIRSCH, JOACHIM, HARVEY, ROBERT J.

“…The strychnine‐sensitive glycine receptor (GlyR) is a pentameric chloride channel protein that exists in several developmentally and regionally regulated…”
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Cellular and subcellular localization of the inhibitory glycine receptor in hippocampal neurons by Brackmann, Marian, Zhao, Congjian, Schmieden, Volker, Braunewell, Karl-Heinz

“…Inhibitory glycine receptors are most abundant in spinal cord and brainstem, and glycinergic synapses have a well-established role in the regulation of…”
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Mutation of Glycine Receptor Subunit Creates β-Alanine Receptor Responsive to GABA by Schmieden, Volker, Kuhse, Jochen, Betz, Heinrich

“…The amino acid at position 160 of the ligand-binding subunit, α1, is an important determinant of agonist and antagonist binding to the glycine receptor…”
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Short Communication: Characterization of the inhibitory glycine receptor on entorhinal cortex neurons by Breustedt, J, Schmitz, D, Heinemann, U, Schmieden, V

“…In addition to the well-established functional description of the glycine receptor (GlyR) in the spinal cord, GlyR expression has recently been found in higher…”
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