Search Results - "Schmiedel, Benjamin J."

Impact of Genetic Polymorphisms on Human Immune Cell Gene Expression by Schmiedel, Benjamin J., Singh, Divya, Madrigal, Ariel, Valdovino-Gonzalez, Alan G., White, Brandie M., Zapardiel-Gonzalo, Jose, Ha, Brendan, Altay, Gokmen, Greenbaum, Jason A., McVicker, Graham, Seumois, Grégory, Rao, Anjana, Kronenberg, Mitchell, Peters, Bjoern, Vijayanand, Pandurangan

“…While many genetic variants have been associated with risk for human diseases, how these variants affect gene expression in various cell types remains largely…”
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Promoter-interacting expression quantitative trait loci are enriched for functional genetic variants by Chandra, Vivek, Bhattacharyya, Sourya, Schmiedel, Benjamin J., Madrigal, Ariel, Gonzalez-Colin, Cristian, Fotsing, Stephanie, Crinklaw, Austin, Seumois, Gregory, Mohammadi, Pejman, Kronenberg, Mitchell, Peters, Bjoern, Ay, Ferhat, Vijayanand, Pandurangan

“…Expression quantitative trait loci (eQTLs) studies provide associations of genetic variants with gene expression but fall short of pinpointing functionally…”
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COVID-19 genetic risk variants are associated with expression of multiple genes in diverse immune cell types by Schmiedel, Benjamin J., Rocha, Job, Gonzalez-Colin, Cristian, Bhattacharyya, Sourya, Madrigal, Ariel, Ottensmeier, Christian H., Ay, Ferhat, Chandra, Vivek, Vijayanand, Pandurangan

“…Common genetic polymorphisms associated with COVID-19 illness can be utilized for discovering molecular pathways and cell types driving disease pathogenesis…”
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Multi-cell type gene coexpression network analysis reveals coordinated interferon response and cross-cell type correlations in systemic lupus erythematosus by Panwar, Bharat, Schmiedel, Benjamin J, Liang, Shu, White, Brandie, Rodriguez, Enrique, Kalunian, Kenneth, McKnight, Andrew J, Soloff, Rachel, Seumois, Gregory, Vijayanand, Pandurangan, Ay, Ferhat

“…Systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately affecting women. A major obstacle in finding targeted therapies for…”
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Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity by Svensson, Mattias Nd, Doody, Karen M, Schmiedel, Benjamin J, Bhattacharyya, Sourya, Panwar, Bharat, Wiede, Florian, Yang, Shen, Santelli, Eugenio, Wu, Dennis J, Sacchetti, Cristiano, Gujar, Ravindra, Seumois, Gregory, Kiosses, William B, Aubry, Isabelle, Kim, Gisen, Mydel, Piotr, Sakaguchi, Shimon, Kronenberg, Mitchell, Tiganis, Tony, Tremblay, Michel L, Ay, Ferhat, Vijayanand, Pandurangan, Bottini, Nunzio

“…Genetic variants at the PTPN2 locus, which encodes the tyrosine phosphatase PTPN2, cause reduced gene expression and are linked to rheumatoid arthritis (RA)…”
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Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation by Schmiedel, Benjamin J., Arélin, Viktor, Gruenebach, Frank, Krusch, Matthias, Schmidt, Susanne M., Salih, Helmut R.

“…Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to…”
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Fc-optimized NKG2D-Fc constructs induce NK cell antibody-dependent cellular cytotoxicity against breast cancer cells independently of HER2/neu expression status by Raab, Stefanie, Steinbacher, Julia, Schmiedel, Benjamin J, Kousis, Philaretos C, Steinle, Alexander, Jung, Gundram, Grosse-Hovest, Ludger, Salih, Helmut R

“…The ability of NK cells to mediate Ab-dependent cellular cytotoxicity (ADCC) largely contributes to the clinical success of antitumor Abs, including…”
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4‐1BB ligand modulates direct and Rituximab‐induced NK‐cell reactivity in chronic lymphocytic leukemia by Buechele, Corina, Baessler, Tina, Schmiedel, Benjamin J., Schumacher, Carla E., Grosse‐Hovest, Ludger, Rittig, Kilian, Salih, Helmut R.

“…NK cells play an important role in tumor immunosurveillance and largely contribute to the therapeutic success of anti‐tumor antibodies like Rituximab. Here, we…”
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Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity by Baltz, Katrin M., Krusch, Matthias, Baessler, Tina, Schmiedel, Benjamin J., Bringmann, Anita, Brossart, Peter, Salih, Helmut R.

“…NK cell anti-tumor reactivity is governed by a balance of activating and inhibitory receptors including various TNF receptor (TNFR) family members. Here we…”
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Single-cell transcriptomic analysis of allergen-specific T cells in allergy and asthma by Seumois, Grégory, Ramírez-Suástegui, Ciro, Schmiedel, Benjamin J, Liang, Shu, Peters, Bjoern, Sette, Alessandro, Vijayanand, Pandurangan

“…CD4 T helper (T ) cells and regulatory T (T ) cells that respond to common allergens play an important role in driving and dampening airway inflammation in…”
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Precursors of human CD4 + cytotoxic T lymphocytes identified by single-cell transcriptome analysis by Patil, Veena S, Madrigal, Ariel, Schmiedel, Benjamin J, Clarke, James, O'Rourke, Patrick, de Silva, Aruna D, Harris, Eva, Peters, Bjoern, Seumois, Gregory, Weiskopf, Daniela, Sette, Alessandro, Vijayanand, Pandurangan

“…CD4 cytotoxic T lymphocytes (CD4-CTLs) have been reported to play a protective role in several viral infections. However, little is known in humans about the…”
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Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response by Pagadala, Meghana, Sears, Timothy J., Wu, Victoria H., Pérez-Guijarro, Eva, Kim, Hyo, Castro, Andrea, Talwar, James V., Gonzalez-Colin, Cristian, Cao, Steven, Schmiedel, Benjamin J., Goudarzi, Shervin, Kirani, Divya, Au, Jessica, Zhang, Tongwu, Landi, Teresa, Salem, Rany M., Morris, Gerald P., Harismendy, Olivier, Patel, Sandip Pravin, Alexandrov, Ludmil B., Mesirov, Jill P., Zanetti, Maurizio, Day, Chi-Ping, Fan, Chun Chieh, Thompson, Wesley K., Merlino, Glenn, Gutkind, J. Silvio, Vijayanand, Pandurangan, Carter, Hannah

“…With the continued promise of immunotherapy for treating cancer, understanding how host genetics contributes to the tumor immune microenvironment (TIME) is…”
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Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type-dependent effects of disease-risk variants by Schmiedel, Benjamin J, Gonzalez-Colin, Cristian, Fajardo, Vicente, Rocha, Job, Madrigal, Ariel, Ramírez-Suástegui, Ciro, Bhattacharyya, Sourya, Simon, Hayley, Greenbaum, Jason A, Peters, Bjoern, Seumois, Grégory, Ay, Ferhat, Chandra, Vivek, Vijayanand, Pandurangan

“…The impact of genetic variants on cells challenged in biologically relevant contexts has not been fully explored. Here, we activated CD4 T cells from 89…”
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Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties by Upadhye, Aditi, Meza Landeros, Kevin E, Ramírez-Suástegui, Ciro, Schmiedel, Benjamin J, Woo, Edwin, Chee, Serena J, Malicki, Denise, Coufal, Nicole G, Gonda, David, Levy, Michael L, Greenbaum, Jason A, Seumois, Grégory, Crawford, John, Roberts, William D, Schoenberger, Stephen P, Cheroutre, Hilde, Ottensmeier, Christian H, Vijayanand, Pandurangan, Ganesan, Anusha-Preethi

“…Brain tumors in children are a devastating disease in a high proportion of patients. Owing to inconsistent results in clinical trials in unstratified patients,…”
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Prognostic relevance of HER2/neu in acute lymphoblastic leukemia and induction of NK cell reactivity against primary ALL blasts by trastuzumab by Haen, Sebastian P, Schmiedel, Benjamin J, Rothfelder, Kathrin, Schmied, Bastian J, Dang, Truong-Minh, Mirza, Nora, Möhle, Robert, Kanz, Lothar, Vogel, Wichard, Salih, Helmut R

“…The epidermal growth factor receptor HER2/neu is expressed on various cancers and represents a negative prognostic marker, but is also a target for the…”
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Membrane-associated phospholipase A1 beta (LIPI) Is an Ewing tumour-associated cancer/testis antigen by Foell, Juergen L., Hesse, Manuela, Volkmer, Ines, Schmiedel, Benjamin J., Neumann, Ingo, Staege, Martin S.

“…Background Cancer/testis antigens (CTA) represent a heterogeneous group of antigens expressed nearly exclusively in tumour cells and testis. Recently, we…”
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Sequence and expression of the chicken membrane-associated phospholipases A1 alpha (LIPH) and beta (LIPI) by Hesse, Manuela, Willscher, Edith, Schmiedel, Benjamin J., Posch, Stefan, Golbik, Ralph P., Staege, Martin S.

“…Cancer/testis antigens (CTA) are a heterogeneous group of antigens that are expressed preferentially in tumor cells and testis. Based on this definition the…”
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Chromatin interaction maps of active cis-regulatory elements in primary human immune cells reveal extensive overlap with disease-associated genetic variants by Chandra, Vivek, Bhattacharyya, Sourya, Schmiedel, Benjamin J., Madrigal, Ariel, Ay, Ferhat, Vijayanand, Pandurangan

“…Abstract Surveys of purified human immune cell types have revealed that common genetic variants have profound effects of gene expression in a highly…”
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Connecting GWAS SNPs to Target Genes in primary human immune cell types by Chandra, Vivek, Bhattacharyya, Sourya, Schmiedel, Benjamin J., Madrigal, Ariel, Gonzalez-Colin, Cristian, Fotsing, Stephanie, Kronenberg, Mitchell, Peters, Bjoern, Ay, Ferhat, Vijayanand, Pandurangan

“…Abstract Expression quantitative trait loci (eQTLs) studies have provided associations with gene expression for many non-coding genetic variants associated…”
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Impact of genetic polymorphisms on human immune cell gene expression by Schmiedel, Benjamin J, Singh, Divya, Madrigal, Ariel, Valdovino-Gonzalez, Alan G, White, Brandie M, Zapardiel-Gonzalo, Jose, Ha, Brendan, Altay, Gokmen, Greenbaum, Jason A, McVicker, Graham, Seumois, Grégory, Rao, Anjana, Kronenberg, Mitchell, Peters, Bjoern, Vijayanand, Pandurangan

“…Abstract While many genetic variants have been associated with risk for human diseases, how these variants affect gene expression in various cell types remains…”
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