Search Results - "Schmiechen, Zoe C"

Mechanisms Governing Immunotherapy Resistance in Pancreatic Ductal Adenocarcinoma by Schmiechen, Zoe C, Stromnes, Ingunn M

“…Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy with an overall 5-year survival rate of 10%. Disease lethality is due to late diagnosis, early…”
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Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma by Patterson, Michael T., Burrack, Adam L., Xu, Yingzheng, Hickok, Grant H., Schmiechen, Zoe C., Becker, Samuel, Cruz-Hinojoza, Eduardo, Schrank, Patricia R., Kennedy, Ainsley E., Firulyova, Maria M., Miller, Ebony A., Zaitsev, Konstantin, Williams, Jesse W., Stromnes, Ingunn M.

“…Pancreatic ductal adenocarcinoma (PDA) orchestrates a suppressive tumor microenvironment that fosters immunotherapy resistance. Tumor-associated macrophages…”
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Chemotherapy brings virtual memory T cells into reality for cancer therapy by Schmiechen, Zoe C., Burrack, Adam L., Stromnes, Ingunn M.

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Distinct myeloid antigen-presenting cells dictate differential fates of tumor-specific CD8+ T cells in pancreatic cancer by Burrack, Adam L, Schmiechen, Zoe C, Patterson, Michael T, Miller, Ebony A, Spartz, Ellen J, Rollins, Meagan R, Raynor, Jackson F, Mitchell, Jason S, Kaisho, Tsuneyasu, Fife, Brian T, Stromnes, Ingunn M

“…We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid…”
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An aged immune system drives senescence and ageing of solid organs by Yousefzadeh, Matthew J., Flores, Rafael R., Zhu, Yi, Schmiechen, Zoe C., Brooks, Robert W., Trussoni, Christy E., Cui, Yuxiang, Angelini, Luise, Lee, Kyoo-A, McGowan, Sara J., Burrack, Adam L., Wang, Dong, Dong, Qing, Lu, Aiping, Sano, Tokio, O’Kelly, Ryan D., McGuckian, Collin A., Kato, Jonathan I., Bank, Michael P., Wade, Erin A., Pillai, Smitha P. S., Klug, Jenna, Ladiges, Warren C., Burd, Christin E., Lewis, Sara E., LaRusso, Nicholas F., Vo, Nam V., Wang, Yinsheng, Kelley, Eric E., Huard, Johnny, Stromnes, Ingunn M., Robbins, Paul D., Niedernhofer, Laura J.

“…Ageing of the immune system, or immunosenescence, contributes to the morbidity and mortality of the elderly 1 , 2 . To define the contribution of immune system…”
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Recent developments in understanding the mechanisms of food allergy by Schmiechen, Zoe C, Weissler, Katherine A, Frischmeyer-Guerrerio, Pamela A

“…The prevalence of food allergy is rising globally. This review will discuss recent discoveries regarding the immunologic mechanisms that drive the initial…”
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CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model by Burrack, Adam L, Rollins, Meagan R, Spartz, Ellen J, Mesojednik, Taylor D, Schmiechen, Zoe C, Raynor, Jackson F, Wang, Iris X, Kedl, Ross M, Stromnes, Ingunn M

“…Pancreatic cancer is a particularly lethal malignancy that resists immunotherapy. In this study, using a preclinical pancreatic cancer murine model, we…”
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Recent developments in understanding the mechanisms of food allergy by Schmiechen, Zoe C, Weissler, Katherine A, Frischmeyer-Guerrerio, Pamela A

“…The prevalence of food allergy is rising globally. This review will discuss recent discoveries regarding the immunologic mechanisms that drive the initial…”
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The effects of altered TGFβ signaling on human T follicular helper cell development and function by Schmiechen, Zoe C, Weissler, Katherine, Laky, Karen, Guerrerio, Pamela

“…Abstract T follicular helper (Tfh) cells are a subset of CD4+ T cells that play a crucial role in the development of memory B cells and plasma cells. T…”
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Abrogating Regulatory T Cells Overcomes Tumor-Specific T cell Exhaustion and Prevents Metastatic Pancreatic Cancer by Schmiechen, Zoe C, Burrack, Adam L, Miller, Ebony, Butler, Jonah, Cruz, Eduardo, Rollins, Meagan, Patterson, Michael, Wang, Iris, Stromnes, Ingunn

“…Abstract Pancreatic ductal adenocarcinoma (PDA) has a dismal 5-year survival rate of 10%. Lethality is attributed to late diagnosis, early metastasis, and…”
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Abrogating regulatory T cells overcomes tumor-specific T cell exhaustion and prevents metastatic pancreatic cancer by Schmiechen, Zoe C, Burrack, Adam L, Miller, Ebony, Rollins, Meagan, Wang, Iris X, Cruz, Eduardo, Patterson, Michael, Stromnes, Ingunn

“…Abstract Pancreatic ductal adenocarcinoma (PDA) is the 4th leading cause of cancer related deaths and has a dismal 5-year survival rate of 10 percent. PDA…”
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Obesity alters the immune landscape of the small intestine and exacerbates food allergy by Schmiechen, Zoe C, Fredrickson, Gavin, Robert, Sacha, Barrow, Fanta, Revelo, Xavier

“…Abstract In the past few decades, higher rates of obesity have coincided with a rising number of individuals affected by allergic disease. Our study objective…”
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Intertumoral CD4+ T-cells instruct monocyte differentiation in pancreatic ductal adenocarcinoma by Patterson, Mike, Burrack, Adam L, Schmiechen, Zoe C, Xu, Yingzheng, Firulyova, Maria, Miller, Ebony, Schrank, Patricia, Zaitsev, Konstantin, Williams, Jesse, Stromnes, Ingunn

“…Abstract Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy that is currently the third leading cause of cancer related deaths. PDA creates a…”
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Agonistic anti-CD40 overcomes T cell exhaustion induced by chronic myeloid cell IL-27 production in a pancreatic cancer preclinical model by Burrack, Adam L., Rollins, Meagan R., Spartz, Ellen J., Mesojednik, Taylor D., Schmiechen, Zoe C., Raynor, Jackson F., Wang, Iris, Kedl, Ross M., Stromnes, Ingunn M.

“…Pancreatic cancer is a particularly lethal malignancy and resists immunotherapy. Here, using a preclinical pancreatic cancer murine model, we demonstrate a…”
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Abstract 2088: ATLAS-identified Inhibigen-specific responses accelerate tumor growth in mouse melanoma and pancreatic cancer by Starobinets, Hanna S., DeVault, Victoria L., Schmiechen, Zoe C., Miller, Ebony A., Cruz, Eduardo, Rollins, Meagan R., Burrack, Adam L., Rinaldi, Stephanie J., Arnold, Julie, Tjon, Emily, Gonzalez, Kyle, Lineker, Dimitry, Lam, Hubert, Stromnes, Ingunn M., Flechtner, Jessica B.

“…Abstract Genocea’s ATLAS platform is an empirical bioassay that uses patient autologous immune cells to identify both true neoantigens and Inhibigens࣪ for…”
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