Search Results - "Schmidt‐Supprian, Marc"

NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology by Vahl, J Christoph, Heger, Klaus, Knies, Nathalie, Hein, Marco Y, Boon, Louis, Yagita, Hideo, Polic, Bojan, Schmidt-Supprian, Marc

“…Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi-invariant Vα14i-TCR. However, to what extent TCR-mediated…”
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CreERT2 expression from within the c‐Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells by Heger, Klaus, Seidler, Barbara, Vahl, J. Christoph, Schwartz, Christian, Kober, Maike, Klein, Sabine, Voehringer, David, Saur, Dieter, Schmidt‐Supprian, Marc

“…Mast cells are abundantly situated at contact sites between the body and its environment, such as the skin and, especially during certain immune responses, at…”
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T Cell Receptor Expression Timing and Signal Strength in the Functional Differentiation of Invariant Natural Killer T Cells by Dashtsoodol, Nyambayar, Bortoluzzi, Sabrina, Schmidt-Supprian, Marc

“…The CD1d-restricted Vα14 invariant NKT (iNKT) cell lineage in mice (Vα24 in humans) represents an evolutionary conserved innate-like immune cell type that…”
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Phosphatidylcholine Synthesis for Lipid Droplet Expansion Is Mediated by Localized Activation of CTP:Phosphocholine Cytidylyltransferase by Krahmer, Natalie, Guo, Yi, Wilfling, Florian, Hilger, Maximiliane, Lingrell, Susanne, Heger, Klaus, Newman, Heather W., Schmidt-Supprian, Marc, Vance, Dennis E., Mann, Matthias, Farese, Robert V., Walther, Tobias C.

“…Lipid droplets (LDs) are cellular storage organelles for neutral lipids that vary in size and abundance according to cellular needs. Physiological conditions…”
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Notch2-mediated plasticity between marginal zone and follicular B cells by Lechner, Markus, Engleitner, Thomas, Babushku, Tea, Schmidt-Supprian, Marc, Rad, Roland, Strobl, Lothar J., Zimber-Strobl, Ursula

“…Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct mature B cell populations in the spleen, originating from a…”
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Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization by Babushku, Tea, Lechner, Markus, Ehrenberg, Stefanie, Rambold, Ursula, Schmidt-Supprian, Marc, Yates, Andrew J., Rane, Sanket, Zimber-Strobl, Ursula, Strobl, Lothar J.

“…Sustained Notch2 signals induce trans-differentiation of Follicular B (FoB) cells into Marginal Zone B (MZB) cells in mice, but the physiology underlying this…”
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Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis by Vereecke, Lars, Sze, Mozes, Mc Guire, Conor, Rogiers, Brecht, Chu, Yuanyuan, Schmidt-Supprian, Marc, Pasparakis, Manolis, Beyaert, Rudi, van Loo, Geert

“…A20 is a nuclear factor kappaB (NF-kappaB) target gene that encodes a ubiquitin-editing enzyme that is essential for the termination of NF-kappaB activation…”
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Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling by Bortoluzzi, Sabrina, Dashtsoodol, Nyambayar, Engleitner, Thomas, Drees, Christoph, Helmrath, Sabine, Mir, Jonas, Toska, Albulena, Flossdorf, Michael, Öllinger, Rupert, Solovey, Maria, Colomé-Tatché, Maria, Kalfaoglu, Bahire, Ono, Masahiro, Buch, Thorsten, Ammon, Tim, Rad, Roland, Schmidt-Supprian, Marc

“…Innate-like T cell populations expressing conserved TCRs play critical roles in immunity through diverse developmentally acquired effector functions. Focusing…”
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Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells by Tan, Likai, Sandrock, Inga, Odak, Ivan, Aizenbud, Yuval, Wilharm, Anneke, Barros-Martins, Joana, Tabib, Yaara, Borchers, Alina, Amado, Tiago, Gangoda, Lahiru, Herold, Marco J., Schmidt-Supprian, Marc, Kisielow, Jan, Silva-Santos, Bruno, Koenecke, Christian, Hovav, Avi-Hai, Krebs, Christian, Prinz, Immo, Ravens, Sarina

“…IL-17-producing γδ T cells express oligoclonal Vγ4+ and Vγ6+ TCRs, mainly develop in the prenatal thymus, and later persist as long-lived self-renewing cells…”
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Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells by Meininger, Isabel, Griesbach, Richard A., Hu, Desheng, Gehring, Torben, Seeholzer, Thomas, Bertossi, Arianna, Kranich, Jan, Oeckinghaus, Andrea, Eitelhuber, Andrea C., Greczmiel, Ute, Gewies, Andreas, Schmidt-Supprian, Marc, Ruland, Jürgen, Brocker, Thomas, Heissmeyer, Vigo, Heyd, Florian, Krappmann, Daniel

“…MALT1 channels proximal T-cell receptor (TCR) signalling to downstream signalling pathways. With MALT1A and MALT1B two conserved splice variants exist and we…”
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B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 by Afzali, Ali Maisam, Nirschl, Lucy, Sie, Christopher, Pfaller, Monika, Ulianov, Oleksii, Hassler, Tobias, Federle, Christine, Petrozziello, Elisabetta, Kalluri, Sudhakar Reddy, Chen, Hsin Hsiang, Tyystjärvi, Sofia, Muschaweckh, Andreas, Lammens, Katja, Delbridge, Claire, Büttner, Andreas, Steiger, Katja, Seyhan, Gönül, Ottersen, Ole Petter, Öllinger, Rupert, Rad, Roland, Jarosch, Sebastian, Straub, Adrian, Mühlbauer, Anton, Grassmann, Simon, Hemmer, Bernhard, Böttcher, Jan P., Wagner, Ingrid, Kreutzfeldt, Mario, Merkler, Doron, Pardàs, Irene Bonafonte, Schmidt Supprian, Marc, Buchholz, Veit R., Heink, Sylvia, Busch, Dirk H., Klein, Ludger, Korn, Thomas

“…Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen 1 . The…”
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Regulation of the Germinal Center Response by MicroRNA-155 by Thai, To-Ha, Calado, Dinis Pedro, Casola, Stefano, Ansel, K. Mark, Xiao, Changchun, Xue, Yingzi, Murphy, Andrew, Frendewey, David, Valenzuela, David, Kutok, Jeffery L, Schmidt-Supprian, Marc, Rajewsky, Nikolaus, Yancopoulos, George, Rao, Anjana, Rajewsky, Klaus

“…MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the…”
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B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice by Chu, Yuanyuan, Vahl, J. Christoph, Kumar, Dilip, Heger, Klaus, Bertossi, Arianna, Wójtowicz, Edyta, Soberon, Valeria, Schenten, Dominik, Mack, Brigitte, Reutelshöfer, Miriam, Beyaert, Rudi, Amann, Kerstin, van Loo, Geert, Schmidt-Supprian, Marc

“…The ubiquitin-editing enzyme A20/TNFAIP3 is essential for controlling signals inducing the activation of nuclear factor-κB transcription factors. Polymorphisms…”
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Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia by Mangolini, Maurizio, Götte, Frederik, Moore, Andrew, Ammon, Tim, Oelsner, Madlen, Lutzny-Geier, Gloria, Klein-Hitpass, Ludger, Williamson, James C., Lehner, Paul J., Dürig, Jan, Möllmann, Michael, Rásó-Barnett, Lívia, Hughes, Katherine, Santoro, Antonella, Méndez-Ferrer, Simón, Oostendorp, Robert A. J., Zimber-Strobl, Ursula, Peschel, Christian, Hodson, Daniel J., Schmidt-Supprian, Marc, Ringshausen, Ingo

“…The Wnt signalling pathway, one of the core de-regulated pathways in chronic lymphocytic leukaemia (CLL), is activated in only a subset of patients through…”
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Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice by Vlantis, Katerina, Wullaert, Andy, Sasaki, Yoshiteru, Schmidt-Supprian, Marc, Rajewsky, Klaus, Roskams, Tania, Pasparakis, Manolis

“…Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important…”
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PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice by Weber, Julia, de la Rosa, Jorge, Grove, Carolyn S., Schick, Markus, Rad, Lena, Baranov, Olga, Strong, Alexander, Pfaus, Anja, Friedrich, Mathias J., Engleitner, Thomas, Lersch, Robert, Öllinger, Rupert, Grau, Michael, Menendez, Irene Gonzalez, Martella, Manuela, Kohlhofer, Ursula, Banerjee, Ruby, Turchaninova, Maria A., Scherger, Anna, Hoffman, Gary J., Hess, Julia, Kuhn, Laura B., Ammon, Tim, Kim, Johnny, Schneider, Günter, Unger, Kristian, Zimber-Strobl, Ursula, Heikenwälder, Mathias, Schmidt-Supprian, Marc, Yang, Fengtang, Saur, Dieter, Liu, Pentao, Steiger, Katja, Chudakov, Dmitriy M., Lenz, Georg, Quintanilla-Martinez, Leticia, Keller, Ulrich, Vassiliou, George S., Cadiñanos, Juan, Bradley, Allan, Rad, Roland

“…B-cell lymphoma (BCL) is the most common hematologic malignancy. While sequencing studies gave insights into BCL genetics, identification of non-mutated cancer…”
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TNF Family Member B Cell-Activating Factor (BAFF) Receptor-Dependent and -Independent Roles for BAFF in B Cell Physiology by Sasaki, Yoshiteru, Casola, Stefano, Kutok, Jeffery L, Rajewsky, Klaus, Schmidt-Supprian, Marc

“…The cytokine TNF family member B cell-activating factor (BAFF; also termed BLyS) is essential for B cell generation and maintenance. Three receptors have been…”
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NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis by Yang, Chang, McCoy, Kathleen, Davis, Jennifer L, Schmidt-Supprian, Marc, Sasaki, Yoshiteru, Faccio, Roberta, Novack, Deborah Veis

“…Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone, and osteoblasts, which build bone. Disproportionate…”
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Yin Yang 1 is a critical regulator of B-cell development by Liu, Huifei, Schmidt-Supprian, Marc, Shi, Yujiang, Hobeika, Elias, Barteneva, Natasha, Jumaa, Hassan, Pelanda, Roberta, Reth, Michael, Skok, Jane, Rajewsky, Klaus, Shi, Yang

“…The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown. Here we show that specific ablation of YY1 in mouse B cells caused a…”
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Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance by Tsaousidou, Eva, Paeger, Lars, Belgardt, Bengt F., Pal, Martin, Wunderlich, Claudia M., Brönneke, Hella, Collienne, Ursel, Hampel, Brigitte, Wunderlich, F. Thomas, Schmidt-Supprian, Marc, Kloppenburg, Peter, Brüning, Jens C.

“…Activation of c-Jun N-terminal kinase 1 (JNK1)- and inhibitor of nuclear factor kappa-B kinase 2 (IKK2)-dependent signaling plays a crucial role in the…”
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