Search Results - "Schmidt, Tim S."

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis by Nakayama, Masanori, Pitulescu, Mara E, Davy, Alice, Nobes, Catherine D, Adams, Ralf H, Sakakibara, Akira, Barberis, Alcide, Benjamin, Laura E, Adams, Susanne, Bochenek, Magdalena L, Lüthi, Urs, Mäkinen, Taija, Schmidt, Tim S, Deutsch, Urban, Wang, Yingdi

“…In development, tissue regeneration or certain diseases, angiogenic growth leads to the expansion of blood vessels and the lymphatic vasculature. This involves…”
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Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease by Schmidt, Tim S, Alp, Nicholas J

“…NO produced by eNOS (endothelial nitric oxide synthase) is a key mediator of vascular homoeostasis. NO bioavailability is reduced early in vascular disease…”
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Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice by Schmidt, Tim S, McNeill, Eileen, Douglas, Gillian, Crabtree, Mark J, Hale, Ashley B, Khoo, Jeffrey, O'Neill, Charles A, Cheng, Alphonsus, Channon, Keith M, Alp, Nicholas J

“…BH4 (tetrahydrobiopterin) supplementation improves endothelial function in models of vascular disease by maintaining eNOS (endothelial nitric oxide synthase)…”
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Depletion of LAG‐3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781 by Ellis, Joanne, J.B. Marks, Daniel, Srinivasan, Naren, Barrett, Christine, Hopkins, Thomas G., Richards, Anna, Fuhr, Rainard, Albayaty, Muna, Coenen, Martin, Liefaard, Lia, Leavens, Karen, Nevin, Katherine L., Tang, Shuo, Hughes, Stephen A., Fortunato, Léa, Edwards, Ken, Cui, Yi, Anselm, Rabia, Delves, Christopher J., Charles, Emilie, Feeney, Maria, Webb, Thomas M., Brett, Sara J., Schmidt, Tim S., Stone, John, Savage, Caroline O.S., Wisniacki, Nicolas, Tarzi, Ruth M.

“…Activated T cells drive a range of immune‐mediated inflammatory diseases. LAG‐3 is transiently expressed on recently activated CD4+ and CD8+ T cells. We…”
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Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure by Moens, An L, Ketner, Elizabeth A, Takimoto, Eiki, Schmidt, Tim S, O'Neill, Charles A, Wolin, Michael S, Alp, Nicholas J, Channon, Keith M, Kass, David A

“…Abstract The exogenous administration of tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), has been shown to reduce left…”
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Single dose oral tetrahydrobiopterin (BH4) leads to a prolonged increase in aortic BH4 levels in ApoE-KO mice by Schmidt, Tim S, Crabtree, Mark J, Hale, Ashley, Alp, Nicholas J

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Using Skin Biopsies to Measure Target Occupancy of a Renal Antifibrotic Monoclonal Antibody (mAb) in a Phase 1 Clinical Study: PO2267 by Bowcutt, Rowann, Johnston, Geoffrey I., Huang, Linghong, Song, James Z., Schmidt, Tim S., Bigley, Alison L., Ogg, Graham, Wong, Eric, Thomson, Elizabeth S., Chan, Jane Y., Raievska, Anastasiia, Johnson, Timothy S.

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Abstract 5201: Low-dose Tetrahydrobiopterin Supplementation Reduces Atherosclerosis Progression in Apolipoprotein E-Knockout Mice via Effects on Vascular T cell Infiltration by Schmidt, Tim S, McNeill, Eileen, Douglas, Gillian, Crabtree, Mark J, Hale, Ashley B, O’Neill, Charles A, Channon, Keith M, Alp, Nicholas J

“…Abstract only Tetrahydrobiopterin (BH4) supplementation improves endothelial function in models of vascular disease by maintaining endothelial nitric oxide…”
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