Search Results - "Schmidt, Sven"

A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitro by Schlaermann, Philipp, Toelle, Benjamin, Berger, Hilmar, Schmidt, Sven C, Glanemann, Matthias, Ordemann, Jürgen, Bartfeld, Sina, Mollenkopf, Hans J, Meyer, Thomas F

“…Helicobacter pylori is the causative agent of gastric diseases and the main risk factor in the development of gastric adenocarcinoma. In vitro studies with…”
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The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain by Schmidt, Sven H., Knape, Matthias J., Boassa, Daniela, Mumdey, Natascha, Kornev, Alexandr P., Ellisman, Mark H., Taylor, Susan S., Herberg, Friedrich W.

“…Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain protein, and LRRK2 mutants are recognized risk factors for Parkinson’s disease (PD). Although the…”
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LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains by Weng, Jui-Hung, Aoto, Phillip C, Lorenz, Robin, Wu, Jian, Schmidt, Sven H, Manschwetus, Jascha T, Kaila-Sharma, Pallavi, Silletti, Steve, Mathea, Sebastian, Chatterjee, Deep, Knapp, Stefan, Herberg, Friedrich W, Taylor, Susan S

“…The 2 major molecular switches in biology, kinases and GTPases, are both contained in the Parkinson disease-related leucine-rich repeat kinase 2 (LRRK2). Using…”
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Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis by Schmidt, Sven, Klampfleuthner, Felicia A.M., Renkawitz, Tobias, Diederichs, Solvig

“…Mesenchymal stromal cells (MSCs) that are promising for cartilage tissue engineering secrete high amounts of prostaglandin E2 (PGE2), an immunoactive mediator…”
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Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2 by Schmidt, Sven H., Weng, Jui-Hung, Aoto, Phillip C., Boassa, Daniela, Mathea, Sebastian, Silletti, Steve, Hu, Junru, Wallbott, Maximilian, Komives, Elizabeth A., Knapp, Stefan, Herberg, Friedrich W., Taylor, Susan S.

“…To explore how pathogenic mutations of the multidomain leucine-rich repeat kinase 2 (LRRK2) hijack its finely tuned activation process and drive Parkinson’s…”
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Anastomotic leak predicts diminished long-term survival after resection for gastric and esophageal cancer by Andreou, Andreas, MD, Biebl, Matthias, MD, Dadras, Mehran, MD, Struecker, Benjamin, MD, Sauer, Igor M., MD, Thuss-Patience, Peter C., MD, Chopra, Sascha, MD, Fikatas, Panagiotis, MD, Bahra, Marcus, MD, Seehofer, Daniel, MD, Pratschke, Johann, MD, Schmidt, Sven-Christian, MD

“…Background Previous studies have reported on the association between perioperative morbidity and diminished oncologic outcomes in patients undergoing resection…”
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2 by Singh, Ranjan K, Soliman, Ahmed, Guaitoli, Giambattista, Störmer, Eliza, von Zweydorf, Felix, Dal Maso, Thomas, Oun, Asmaa, Van Rillaer, Laura, Schmidt, Sven H, Chatterjee, Deep, David, Joshua A, Pardon, Els, Schwartz, Thomas U, Knapp, Stefan, Kennedy, Eileen J, Steyaert, Jan, Herberg, Friedrich W, Kortholt, Arjan, Gloeckner, Christian Johannes, Versées, Wim

“…Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) are a leading cause of the inherited form of Parkinson's disease (PD), while LRRK2…”
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Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2 by Manschwetus, Jascha T, Wallbott, Maximilian, Fachinger, Alexandra, Obergruber, Claudia, Pautz, Sabine, Bertinetti, Daniela, Schmidt, Sven H, Herberg, Friedrich W

“…Proteins of the 14-3-3 family are well known modulators of the leucine-rich repeat kinase 2 (LRRK2) regulating kinase activity, cellular localization, and…”
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Antibody Profiling: Kinetics with Native Biomarkers for Diagnostic Assay and Drug Developments by Jucknischke, Ute, Friebe, Sebastian, Rehle, Markus, Quast, Laura, Schmidt, Sven H

“…Despite remarkable progress in applied Surface Plasmon Resonance (SPR)-based methods, concise monitoring of kinetic properties for native biomarkers from…”
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Optimization of a drug transporter probe cocktail: potential screening tool for transporter‐mediated drug–drug interactions by Stopfer, Peter, Giessmann, Thomas, Hohl, Kathrin, Hutzel, Sabine, Schmidt, Sven, Gansser, Dietmar, Ishiguro, Naoki, Taub, Mitchell E., Sharma, Ashish, Ebner, Thomas, Müller, Fabian

“…Aims Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P‐gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1,…”
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Enhanced possibilities to make statements on the ossification status of the medial clavicular epiphysis using an amplified staging scheme in evaluating thin-slice CT scans by Kellinghaus, Manuel, Schulz, Ronald, Vieth, Volker, Schmidt, Sven, Pfeiffer, Heidi, Schmeling, Andreas

“…Thin-slice computed tomography provides the imaging modality of choice in analysing the ossification process of the medial clavicular epiphysis for the purpose…”
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Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity by Lorenz, Robin, Moon, Eui-Whan, Kim, Jeong Joo, Schmidt, Sven H, Sankaran, Banumathi, Pavlidis, Ioannis V, Kim, Choel, Herberg, Friedrich W

“…Cyclic AMP and cyclic GMP are ubiquitous second messengers that regulate the activity of effector proteins in all forms of life. The main effector proteins,…”
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MAMPI-UWB-Multipath-Assisted Device-Free Localization with Magnitude and Phase Information with UWB Transceivers by Cimdins, Marco, Schmidt, Sven Ole, Hellbrück, Horst

“…In this paper, we propose a multipath-assisted device-free localization (DFL) system that includes magnitude and phase information (MAMPI). The DFL system…”
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Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: a revision of the prohypertrophic signalling network concept by Diederichs, Solvig, Dreher, Simon I, Nüesch, Sarah Anna, Schmidt, Sven, Merle, Christian, Richter, Wiltrud

“…In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields…”
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Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery by Taylor, Susan S., Kaila-Sharma, Pallavi, Weng, Jui-Hung, Aoto, Phillip, Schmidt, Sven H., Knapp, Stefan, Mathea, Sebastian, Herberg, Friedrich W.

“…Protein kinases and GTPases are the two major molecular switches that regulate much of biology, and both of these domains are embedded within the large…”
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A Disintegrin and Metalloproteinase 17 (ADAM17) Mediates Inflammation-induced Shedding of Syndecan-1 and -4 by Lung Epithelial Cells by Pruessmeyer, Jessica, Martin, Christian, Hess, Franz M., Schwarz, Nicole, Schmidt, Sven, Kogel, Tanja, Hoettecke, Nicole, Schmidt, Boris, Sechi, Antonio, Uhlig, Stefan, Ludwig, Andreas

“…Syndecans are cell surface proteoglycans that bind and modulate various proinflammatory mediators and can be proteolytically shed from the cell surface. Within…”
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Surgical Repair of a Traumatic Gastrobronchial Fistula by Schmidt, Sven C, Möller, Julia, Schütte, Hartwig, Matz, Robert, Matthees, Bert, Marusch, Frank

“…BACKGROUND Gastrobronchial fistulas mostly occur as a result of postoperative complications, including those of bariatric, esophageal, and spleno-pancreatic…”
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Analysis of Transpulmonary Thermodilution Data Confirms the Influence of Renal Replacement Therapy on Thermodilution Hemodynamic Measurements by Schmidt, Sven, Westhoff, Timm, Schlattmann, Peter, Zidek, Walter, Compton, Friederike

“…BACKGROUND:Transpulmonary thermodilution (TPTD) is used frequently in the intensive care unit to determine cardiac index (CI), intrathoracic blood volume index…”
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Impact of Atrial Fibrillation on the Accuracy of Oscillometric Blood Pressure Monitoring by Pagonas, Nikolaos, Schmidt, Sven, Eysel, Jörg, Compton, Friederike, Hoffmann, Clemens, Seibert, Felix, Hilpert, Justus, Tschöpe, Carsten, Zidek, Walter, Westhoff, Timm H.

“…The introduction of automated oscillometric blood pressure monitors was the basis for today’s widespread use of blood pressure self-measurement. However, in…”
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Sonographic evaluation of apophyseal ossification of the iliac crest in forensic age diagnostics in living individuals by Schmidt, Sven, Schmeling, Andreas, Zwiesigk, Per, Pfeiffer, Heidi, Schulz, Ronald

“…Due to the requirement to minimise exposure to radiation, it is desirable to develop non-ionising imaging procedures for the analysis of skeletal maturation…”
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