Search Results - "Schmidt, Stephan"

In silico fragmentation for computer assisted identification of metabolite mass spectra by Wolf, Sebastian, Schmidt, Stephan, Müller-Hannemann, Matthias, Neumann, Steffen

“…Mass spectrometry has become the analytical method of choice in metabolomics research. The identification of unknown compounds is the main bottleneck. In…”
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Profiling of secondary metabolites in root exudates of Arabidopsis thaliana by Strehmel, Nadine, Böttcher, Christoph, Schmidt, Stephan, Scheel, Dierk

“…Root exudates obtained from hydroponically cultivated Arabidopsis thaliana were analyzed by non-targeted metabolite profiling using UPLC/ESI-QTOFMS. A total of…”
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Importance of Relating Efficacy Measures to Unbound Drug Concentrations for Anti-Infective Agents by GONZALEZ, Daniel, SCHMIDT, Stephan, DERENDORF, Hartmut

“…Classifications Services CMR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Spotlight on P2X7 Receptor PET Imaging: A Bright Target or a Failing Star? by Schmidt, Stephan, Isaak, Andreas, Junker, Anna

“…The homotrimeric P2X7 receptor (P2X7R) is expressed by virtually all cells of the innate and adaptive immune system and plays a crucial role in various…”
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Significance of protein binding in pharmacokinetics and pharmacodynamics by Schmidt, Stephan, Gonzalez, Daniel, Derendorf, Hartmut

“…The significance of plasma protein binding on drug efficacy and, subsequently, the clinical relevance of changes in protein binding has been controversially…”
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Arabidopsis Transporter ABCG37/PDR9 contributes primarily highly oxygenated Coumarins to Root Exudation by Ziegler, Jörg, Schmidt, Stephan, Strehmel, Nadine, Scheel, Dierk, Abel, Steffen

“…The chemical composition of root exudates strongly impacts the interactions of plants with microorganisms in the rhizosphere and the efficiency of nutrient…”
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Non-targeted profiling of semi-polar metabolites in Arabidopsis root exudates uncovers a role for coumarin secretion and lignification during the local response to phosphate limitation by Ziegler, Jörg, Schmidt, Stephan, Chutia, Ranju, Müller, Jens, Böttcher, Christoph, Strehmel, Nadine, Scheel, Dierk, Abel, Steffen

“…Plants have evolved two major strategies to cope with phosphate (Pi) limitation. The systemic response, mainly comprising increased Pi uptake and metabolic…”
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Natural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data by Mönchgesang, Susann, Strehmel, Nadine, Schmidt, Stephan, Westphal, Lore, Taruttis, Franziska, Müller, Erik, Herklotz, Siska, Neumann, Steffen, Scheel, Dierk

“…Many metabolomics studies focus on aboveground parts of the plant, while metabolism within roots and the chemical composition of the rhizosphere, as influenced…”
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Real-world effect of a potential drug-drug interaction between topiramate and oral contraceptives on unintended pregnancy outcomes by Sarayani, Amir, Winterstein, Almut, Cristofoletti, Rodrigo, Vozmediano, Valva, Schmidt, Stephan, Brown, Joshua

“…To evaluate the association of concomitant topiramate and oral hormonal contraceptive use with unintended pregnancies. We conducted a retrospective cohort…”
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Packing Density Control in P(NIPAM-co-AAc) Microgel Monolayers: Effect of Surface Charge, pH, and Preparation Technique by Schmidt, Stephan, Hellweg, Thomas, von Klitzing, Regine

“…In the present paper, thermosensitive coatings are prepared by deposition of P(NIPAM-co-AAc) microgel particles on precoated silicon wafers. The effect of pH,…”
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A quantitative systems pharmacology (QSP) platform for preclinical to clinical translation of in-vivo CRISPR-Cas therapy by Desai, Devam A, Schmidt, Stephan, Cristofoletti, Rodrigo

“…In-vivo CRISPR Cas genome editing is a complex therapy involving lipid nanoparticle (LNP), messenger RNA (mRNA), and single guide RNA (sgRNA). This novel…”
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Development of a population pharmacokinetic model characterizing the tissue distribution of azithromycin in healthy subjects by Zheng, Songmao, Matzneller, Peter, Zeitlinger, Markus, Schmidt, Stephan

“…Recent clinical trials indicate that the use of azithromycin is associated with the emergence of macrolide resistance. The objective of our study was to…”
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A Simple Condition Monitoring Method for Gearboxes Operating in Impulsive Environments by Schmidt, Stephan, Zimroz, Radoslaw, Chaari, Fakher, Heyns, P Stephan, Haddar, Mohamed

“…Reliable condition indicators are necessary to perform effective diagnosis and prognosis. However, the vibration signals are often corrupted with non-Gaussian…”
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Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines by Luca, Anna C, Mersch, Sabrina, Deenen, René, Schmidt, Stephan, Messner, Isabelle, Schäfer, Karl-Ludwig, Baldus, Stephan E, Huckenbeck, Wolfgang, Piekorz, Roland P, Knoefel, Wolfram T, Krieg, Andreas, Stoecklein, Nikolas H

“…Three-dimensional (3D) tumor cell cultures grown in laminin-rich-extracellular matrix (lrECM) are considered to reflect human tumors more realistic as compared…”
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Radial profile detection of multiple spherical particles in contact with interacting surfaces by Waschke, Johannes, Pompe, Tilo, Rettke, David, Schmidt, Stephan, Hlawitschka, Mario

“…Adhesive interactions of soft materials play an important role in nature and technology. Interaction energies can be quantified by determining contact areas of…”
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Optimization of Experimental Conditions of Automated Glucuronidation Assays in Human Liver Microsomes Using a Cocktail Approach and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry by Badée, Justine, Qiu, Nahong, Parrott, Neil, Collier, Abby C, Schmidt, Stephan, Fowler, Stephen

“…UDP-glucuronosyltransferase (UGT)-mediated metabolism is possibly the most important conjugation reaction for marketed drugs. However, there are currently no…”
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Optimization of Voriconazole Therapy for the Treatment of Invasive Fungal Infections in Adults by Mangal, Naveen, Hamadeh, Issam S., Arwood, Meghan J., Cavallari, Larisa H., Samant, Tanay S., Klinker, Kenneth P., Bulitta, Jurgen, Schmidt, Stephan

“…Therapeutic concentrations of voriconazole in invasive fungal infections (IFIs) are ensured using a drug monitoring approach, which relies on attainment of…”
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Mechanoresponsive lipid-protein nanoglobules facilitate reversible fibre formation in velvet worm slime by Baer, Alexander, Schmidt, Stephan, Haensch, Sebastian, Eder, Michaela, Mayer, Georg, Harrington, Matthew J.

“…Velvet worms eject a fluid capture slime that can be mechanically drawn into stiff biopolymeric fibres. Remarkably, these fibres can be dissolved by extended…”
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Sequence-defined positioning of amine and amide residues to control catechol driven wet adhesion by Fischer, Lukas, Strzelczyk, Alexander K, Wedler, Nils, Kropf, Christian, Schmidt, Stephan, Hartmann, Laura

“…Catechol and amine residues, both abundantly present in mussel adhesion proteins, are known to act cooperatively by displacing hydration barriers before…”
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Experiences of persons with Multiple Sclerosis with lifestyle adjustment-A qualitative interview study by Elkhalii-Wilhelm, Saskia, Sippel, Anna, Riemann-Lorenz, Karin, Kofahl, Christopher, Scheiderbauer, Jutta, Arnade, Sigrid, Kleiter, Ingo, Schmidt, Stephan, Heesen, Christoph

“…Persons with Multiple Sclerosis (pwMS) follow individual strategies to cope with this highly heterogeneous disease. As surveys show, lifestyle habits play an…”
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