Search Results - "Schmidt, Robin H"
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Metabolomic Analysis of the Effects of Chronic Arsenic Exposure in a Mouse Model of Diet-Induced Fatty Liver Disease
Published in Journal of proteome research (07-02-2014)“…Arsenic is a widely distributed environmental component that is associated with a variety of cancer and non-cancer adverse health effects. Additional lifestyle…”
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Journal Article -
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MetPP: a computational platform for comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics
Published in Bioinformatics (15-07-2013)“…Due to the high complexity of metabolome, the comprehensive 2D gas chromatography time-of-flight mass spectrometry (GC×GC-TOF MS) is considered as a powerful…”
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Journal Article -
3
Olanzapine activates hepatic mammalian target of rapamycin: new mechanistic insight into metabolic dysregulation with atypical antipsychotic drugs
Published in The Journal of pharmacology and experimental therapeutics (01-10-2013)“…Olanzapine (OLZ), an effective treatment of schizophrenia and other disorders, causes weight gain and metabolic syndrome. Most studies to date have focused on…”
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Journal Article -
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Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha
Published in Alcoholism, clinical and experimental research (01-10-2015)“…Background It is well known that liver and lung injury can occur simultaneously during severe inflammation (e.g., multiple organ failure). However, whether…”
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Journal Article -
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Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction
Published in Toxicology and applied pharmacology (01-05-2015)“…Arsenic (As) tops the ATSDR list of hazardous environmental chemicals and is known to cause liver injury. Although the concentrations of As found in the US…”
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Journal Article -
6
Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration
Published in Investigative ophthalmology & visual science (01-01-2018)“…To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of…”
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Journal Article -
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Chronic subhepatotoxic exposure to arsenic enhances hepatic injury caused by high fat diet in mice
Published in Toxicology and applied pharmacology (15-12-2011)“…Arsenic is a ubiquitous contaminant in drinking water. Whereas arsenic can be directly hepatotoxic, the concentrations/doses required are generally higher than…”
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Journal Article -
8
Exercise as Gene Therapy: BDNF and DNA Damage Repair
Published in Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) (01-07-2016)“…DNA damage is a common feature of neurodegenerative illnesses, and the ability to repair DNA strand breaks and lesions is crucial for neuronal survival,…”
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Potential Role of Exercise in Retinal Health
Published in Progress in molecular biology and translational science (2015)“…For many patients suffering vision loss due to retinal degeneration, the potential exists for therapeutic intervention to halt or delay disease progression…”
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Journal Article -
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Olanzapine-induced liver injury: Direct metabolic effects, exacerbation by high-fat diet, and protection with sulforaphane
Published 01-01-2014“…Olanzapine (OLZ) is an effective first-line treatment for schizophrenia and bipolar disorder. The benefits of OLZ are countermanded by side effects such as…”
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Dissertation -
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Sulforaphane prevents acetaminophen-induced hepatic injury in mice
Published 01-01-2011“…Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with…”
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Dissertation -
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Sulforaphane prevents acetaminophen-induced hepatic injury in mice
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Dissertation