Search Results - "Schmidt, Peter M"

The Endocannabinoid Anandamide Protects Neurons during CNS Inflammation by Induction of MKP-1 in Microglial Cells by Eljaschewitsch, Eva, Witting, Anke, Mawrin, Christian, Lee, Thomas, Schmidt, Peter M., Wolf, Susanne, Hoertnagl, Heide, Raine, Cedric S., Schneider-Stock, Regine, Nitsch, Robert, Ullrich, Oliver

“…Endocannabinoids are released after brain injury and believed to attenuate neuronal damage by binding to CB 1 receptors and protecting against excitotoxicity…”
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Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels by Stasch, Johannes-Peter, Schmidt, Peter M, Nedvetsky, Pavel I, Nedvetskaya, Tatiana Y, H S, Arun Kumar, Meurer, Sabine, Deile, Martin, Taye, Ashraf, Knorr, Andreas, Lapp, Harald, Müller, Helmut, Turgay, Yagmur, Rothkegel, Christiane, Tersteegen, Adrian, Kemp-Harper, Barbara, Müller-Esterl, Werner, Schmidt, Harald H H W

“…ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging…”
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Targeting coagulation factor XII as a novel therapeutic option in brain trauma by Hopp, Sarah, Albert-Weissenberger, Christiane, Mencl, Stine, Bieber, Michael, Schuhmann, Michael K., Stetter, Christian, Nieswandt, Bernhard, Schmidt, Peter M., Monoranu, Camelia-Maria, Alafuzoff, Irina, Marklund, Niklas, Nolte, Marc W., Sirén, Anna-Leena, Kleinschnitz, Christoph

“…Objective Traumatic brain injury is a major global public health problem for which specific therapeutic interventions are lacking. There is, therefore, a…”
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Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses by Barrett, Susan, Mohr, Peter G, Schmidt, Peter M, McKimm-Breschkin, Jennifer L

“…The influenza neuraminidase (NA) inhibitors zanamivir, oseltamivir and peramivir were all designed based on the knowledge that the transition state analogue of…”
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Nitric Oxide–Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation by Meurer, Sabine, Pioch, Sylke, Pabst, Tatjana, Opitz, Nils, Schmidt, Peter M, Beckhaus, Tobias, Wagner, Kristina, Matt, Simone, Gegenbauer, Kristina, Geschka, Sandra, Karas, Michael, Stasch, Johannes-Peter, Schmidt, Harald H.H.W, Müller-Esterl, Werner

“…Nitric oxide (NO) is an essential vasodilator. In vascular diseases, oxidative stress attenuates NO signaling by both chemical scavenging of free NO and…”
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A generic system for the expression and purification of soluble and stable influenza neuraminidase by Schmidt, Peter M, Attwood, Rebecca M, Mohr, Peter G, Barrett, Susan A, McKimm-Breschkin, Jennifer L

“…The influenza surface glycoprotein neuraminidase (NA) is essential for the efficient spread of the virus. Antiviral drugs such as Tamiflu (oseltamivir) and…”
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Taking down the FLAG! How insect cell expression challenges an established tag-system by Schmidt, Peter M, Sparrow, Lindsay G, Attwood, Rebecca M, Xiao, Xiaowen, Adams, Tim E, McKimm-Breschkin, Jennifer L

“…In 1988 the preceding journal of Nature Biotechnology, Bio/Technology, reported a work by Hopp and co-workers about a new tag system for the identification and…”
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Phenotype-specific recombinant haptoglobin polymers co-expressed with C1r-like protein as optimized hemoglobin-binding therapeutics by Schaer, Christian A, Owczarek, Catherine, Deuel, Jeremy W, Schauer, Stefan, Baek, Jin Hyen, Yalamanoglu, Ayla, Hardy, Matthew P, Scotney, Pierre D, Schmidt, Peter M, Pelzing, Matthias, Soupourmas, Peter, Buehler, Paul W, Schaer, Dominik J

“…Preclinical studies have evaluated haptoglobin (Hp) polymers from pooled human plasma as a therapeutic protein to attenuate toxic effects of cell-free…”
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Identification of Residues Crucially Involved in the Binding of the Heme Moiety of Soluble Guanylate Cyclase by Schmidt, Peter M., Schramm, Matthias, Schröder, Henning, Wunder, Frank, Stasch, Johannes-Peter

“…Soluble guanylate cyclase (sGC), a heterodimeric hemeprotein, is the only receptor for the biological messenger nitric oxide (NO) identified to date and is…”
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Technical Optimization for the High-Throughput Purification of Antibodies on Automated Liquid Handlers by Schmidt, Peter M

“…Monoclonal antibodies (mAbs) are the fastest-growing segment in the drug market with eight of the top 20 selling drugs being mAbs and combined sales of close…”
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Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells by Hoffmann, Linda S, Schmidt, Peter M, Keim, Yvonne, Hoffmann, Carsten, Schmidt, Harald H H W, Stasch, Johannes-Peter

“…In cardiovascular disease, the protective NO/sGC/cGMP signalling-pathway is impaired due to a decreased pool of NO-sensitive haem-containing sGC accompanied by…”
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Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo by Rothkegel, Christiane, Schmidt, Peter M, Atkins, Derek-John, Hoffmann, Linda Sarah, Schmidt, Harald H H W, Schröder, Henning, Stasch, Johannes-Peter

“…The ubiquitously expressed nitric oxide (NO) receptor soluble guanylate cyclase (sGC) plays a key role in signal transduction. Binding of NO to the N-terminal…”
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Identification of a modified coagulation factor X with enhanced activation properties as potential hemostatic agent by Ebert, Mariana, Raquet, Elmar, Schweisgut, Sabine, Schmidt, Peter M., Weimer, Thomas

“…Hemophilia A and hemophilia B are X-linked inherited bleeding disorders caused by a deficiency of coagulation factor VIII and IX, respectively. Standard of…”
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Identification of residues crucially involved in soluble guanylate cyclase activation by Rothkegel, Christiane, Schmidt, Peter M., Stoll, Friederike, Schröder, Henning, Schmidt, Harald H.H.W., Stasch, Johannes-Peter

“…The ubiquitous heterodimeric nitric oxide (NO) receptor soluble guanylate cyclase (sGC) plays a key role in various signal transduction pathways. Binding of NO…”
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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential by Evgenov, Oleg V, Pacher, Pál, Schmidt, Peter M, Haskó, György, Schmidt, Harald H. H. W, Stasch, Johannes-Peter

“…Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). Impaired bioavailability and/or responsiveness to…”
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Detection of activity of telomerase in tumor cells using fiber optical biosensors by Schmidt, Peter M, Lehmann, Christine, Matthes, Eckart, Bier, Frank F

“…Human telomerase plays an important role in the cancerogenesis as it is up-regulated in 80–90% of malignant tumors. Thus, it is considered as a potential…”
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NO- and haem-independent soluble guanylate cyclase activators by Schmidt, Harald H H W, Schmidt, Peter M, Stasch, Johannes-Peter

“…Oxidative stress, a risk factor for several cardiovascular disorders, interferes with the NO/sGC/cGMP signalling pathway through scavenging of NO and formation…”
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A robust robotic high-throughput antibody purification platform by Schmidt, Peter M., Abdo, Michael, Butcher, Rebecca E., Yap, Min-Yin, Scotney, Pierre D., Ramunno, Melanie L., Martin-Roussety, Genevieve, Owczarek, Catherine, Hardy, Matthew P., Chen, Chao-Guang, Fabri, Louis J.

“…•Two stage robust antibody purification platform has been established.•High yield preparative antibody purification for initial screening…”
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Optimizing high throughput antibody purification by using continuous chromatography media by Butcher, Rebecca E., Martin-Roussety, Genevieve, Bradford, Rebecca A., Tester, Andrea, Owczarek, Catherine, Hardy, Matthew P., Chen, Chao-Guang, Sansome, Georgina, Fabri, Louis J., Schmidt, Peter M.

“…The ability to engineer monoclonal antibodies (mAbs) with high specificity made mAbs the fastest growing segment in the drug market. mAbs represent 8 of the…”
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Structure of an Influenza A virus N9 neuraminidase with a tetrabrachion‐domain stalk by Streltsov, Victor A., Schmidt, Peter M., McKimm-Breschkin, Jennifer L.

“…The influenza neuraminidase (NA) is a homotetramer with head, stalk, transmembrane and cytoplasmic regions. The structure of the NA head with a stalk has never…”
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