Search Results - "Schmidt, Michael M."

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting by Schmidt, Michael M, Wittrup, K Dane

“…A diverse array of tumor targeting agents ranging in size from peptides to nanoparticles is currently under development for applications in cancer imaging and…”
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Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance by Thurber, Greg M., Schmidt, Michael M., Wittrup, K. Dane

“…Antibodies have proven to be effective agents in cancer imaging and therapy. One of the major challenges still facing the field is the heterogeneous…”
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Practical theoretic guidance for the design of tumor-targeting agents by Wittrup, K Dane, Thurber, Greg M, Schmidt, Michael M, Rhoden, John J

“…Theoretical analyses of targeting agent pharmacokinetics provides specific guidance with respect to desirable design objectives such as agent size, affinity,…”
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Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface by Schmidt, Michael M., Townson, Sharon A., Andreucci, Amy J., King, Bracken M., Schirmer, Emily B., Murillo, Alec J., Dombrowski, Christian, Tisdale, Alison W., Lowden, Patricia A., Masci, Allyson L., Kovalchin, Joseph T., Erbe, David V., Wittrup, K. Dane, Furfine, Eric S., Barnes, Thomas M.

“…The long circulating half-life of serum albumin, the most abundant protein in mammalian plasma, derives from pH-dependent endosomal salvage from degradation,…”
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Kinetics of anti-carcinoembryonic antigen antibody internalization: effects of affinity, bivalency, and stability by Schmidt, Michael M., Thurber, Greg M., Wittrup, K. Dane

“…Theoretical analyses suggest that the cellular internalization and catabolism of bound antibodies contribute significantly to poor penetration into tumors…”
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Intratumorally anchored cytokine therapy by Wittrup, K Dane, Kaufman, Howard L, Schmidt, Michael M, Irvine, Darrell J

“…On-target, off-tumor toxicity severely limits systemic dosing of cytokines and agonist antibodies for cancer. Intratumoral administration is increasingly being…”
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Monovalent, reduced-size quantum dots for imaging receptors on living cells by Ting, Alice Y, Howarth, Mark, Liu, Wenhao, Puthenveetil, Sujiet, Zheng, Yi, Marshall, Lisa F, Schmidt, Michael M, Wittrup, K Dane, Bawendi, Moungi G

“…We describe a method to generate monovalent quantum dots (QDs) using agarose gel electrophoresis. We passivated QDs with a carboxy-terminated…”
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Factors determining antibody distribution in tumors by Thurber, Greg M, Schmidt, Michael M, Wittrup, K. Dane

“…The development of antibody therapies for cancer is increasing rapidly, primarily owing to their specificity. Antibody distribution in tumors is often…”
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Intratumoral aluminum hydroxide-anchored IL-12 drives potent antitumor activity by remodeling the tumor microenvironment by Battula, Sailaja, Papastoitsis, Gregory, Kaufman, Howard L, Wittrup, K Dane, Schmidt, Michael M

“…IL-12 is a potent cytokine that can promote innate and adaptive anticancer immunity, but its clinical development has been limited by toxicity when delivered…”
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Differentiated agonistic antibody targeting CD137 eradicates large tumors without hepatotoxicity by Eskiocak, Ugur, Guzman, Wilson, Wolf, Benjamin, Cummings, Christine, Milling, Lauren, Wu, Hsin-Jung, Ophir, Michael, Lambden, Conner, Bakhru, Pearl, Gilmore, Dana C, Ottinger, Samantha, Liu, Lucy, McConaughy, William K, He, Sunny Q, Wang, Chao, Leung, Cheuk Lun, Lajoie, Jason, Carson, 4th, William F, Zizlsperger, Nora, Schmidt, Michael M, Anderson, Ana C, Bobrowicz, Piotr, Schuetz, Thomas J, Tighe, Robert

“…CD137 (4-1BB) is a member of the TNFR superfamily that represents a promising target for cancer immunotherapy. Recent insights into the function of TNFR…”
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A33 antigen displays persistent surface expression by Ackerman, Margaret E., Chalouni, Cecile, Schmidt, Michael M., Raman, Vivek V., Ritter, Gerd, Old, Lloyd J., Mellman, Ira, Wittrup, K. Dane

“…The A33 antigen is a cell surface glycoprotein of the small intestine and colonic epithelium with homology to tight junction-associated proteins of the…”
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Zebrafish brd2a and brd2b are paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence by Dibenedetto, Angela J, Guinto, Jake B, Ebert, Timothy D, Bee, Katharine J, Schmidt, Michael M, Jackman, Todd R

“…Brd2 belongs to the bromodomain-extraterminal domain (BET) family of transcriptional co-regulators, and functions as a pivotal histone-directed recruitment…”
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Ultra-High Performance Concrete UHPC: Fundamentals, Design, Examples by Fehling, Ekkehard, Schmidt, Michael, Walraven, Joost, Leutbecher, Torsten, öhlich, Susanne

“…Selected chapters from the German concrete yearbook are now being published in the new English "Beton-Kalender Series" for the benefit of an international…”
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Abstract 365: Intratumoral delivery of aluminum hydroxide-tethered IL-12 induces potent anti-tumor immune response by Battula, Sailaja, Papastoitsis, Gregory, Kaufman, Howard L., Irvine, Darrell J., Wittrup, K. Dane, Schmidt, Michael M.

“…IL-12 is a potent cytokine that mediates anti-tumor immune response, but its clinical development has been hindered by systemic toxicity. Intratumoral (IT)…”
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Adenosine Receptor Activation in the “Trigger” Limb of Remote Pre-Conditioning Mediates Human Endothelial Conditioning and Release of Circulating Cardioprotective Factor(s) by Contractor, Hussain, MBChB, DPhil, Lie, Rasmus Haarup, MD, PhD, Cunnington, Colin, MBChB, DPhil, Li, Jing, PhD, Støttrup, Nicolaj B., MD, PhD, Manlhiot, Cedric, BSc, Bøtker, Hans Erik, MD, PhD, Schmidt, Michael R., MD, PhD, Forfar, J. Colin, MD, PhD, Ashrafian, Houman, MB BChir, DPhil, Redington, Andrew, MBBS, PhD, Kharbanda, Rajesh K., MBChB, PhD

“…Visual Abstract…”
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Antibody tumor penetration : Transport opposed by systemic and antigen-mediated clearance: Delivery Systems for the Targeted Radiotherapy of Cancer by THURBER, Greg M, SCHMIDT, Michael M, WITTRUP, K. Dane

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Impact of Professional Society Guideline Publications in Medicine Subspecialties From 2012 to 2022: Implications for Clinical Care and Health Policy by Jhawar, Nikita, Mai, William Klaus, Schneider, Artur, Schmidt, William Michael, Xie, Guozhen, Sharma, Abhishek, Parker, Christopher Bennett, Kusumoto, Fred

“…Clinical guidelines have become an integral part of clinical care. We assessed professional society-based clinical guidelines from 2012 to 2022 to elucidate…”
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Zebrafish brd2a and brd2bare paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence by DiBenedetto, Angela J, Guinto, Jake B, Ebert, Timothy D, Bee, Katharine J, Schmidt, Michael M, Jackman, Todd R

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Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial by Bøtker, Hans Erik, Prof, Kharbanda, Rajesh, MD, Schmidt, Michael R, MD, Bøttcher, Morten, MD, Kaltoft, Anne K, MD, Terkelsen, Christian J, MD, Munk, Kim, MD, Andersen, Niels H, MD, Hansen, Troels M, MD, Trautner, Sven, MD, Lassen, Jens Flensted, MD, Christiansen, Evald Høj, MD, Krusell, Lars R, MD, Kristensen, Steen D, MD, Thuesen, Leif, MD, Nielsen, Søren S, MD, Rehling, Michael, MD, Sørensen, Henrik Toft, Prof, Redington, Andrew N, Prof, Nielsen, Torsten T, Prof

“…Summary Background Remote ischaemic preconditioning attenuates cardiac injury at elective surgery and angioplasty. We tested the hypothesis that remote…”
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ED operational factors associated with patient satisfaction by Goloback, Molly, MD, McCarthy, Danielle M., MD, MS, Schmidt, Michael, MD, Adams, James G., MD, Pang, Peter S., MD, MSc

“…Per institutional protocol, 30% of discharged patients are randomly selected to receive the Press Ganey (PG) patient satisfaction survey, a psychometrically…”
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