Search Results - "Schmidt, James J."

Small molecules showing significant protection of mice against botulinum neurotoxin serotype A by Pang, Yuan-Ping, Davis, Jon, Wang, Shaohua, Park, Jewn Giew, Nambiar, Madhusoodana P, Schmidt, James J, Millard, Charles B

“…Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism that could afflict large, unprotected populations if…”
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Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular design by Pang, Yuan-Ping, Vummenthala, Anuradha, Mishra, Rajesh K, Park, Jewn Giew, Wang, Shaohua, Davis, Jon, Millard, Charles B, Schmidt, James J

“…Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism. Current treatment for post exposure of BoNTA uses…”
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Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons by Burnett, James C., Ruthel, Gordon, Stegmann, Christian M., Panchal, Rekha G., Nguyen, Tam L., Hermone, Ann R., Stafford, Robert G., Lane, Douglas J., Kenny, Tara A., McGrath, Connor F., Wipf, Peter, Stahl, Andrea M., Schmidt, James J., Gussio, Rick, Brunger, Axel T., Bavari, Sina

“…An efficient research strategy integrating empirically guided, structure-based modeling and chemoinformatics was used to discover potent small molecule…”
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Fluorigenic Substrates for the Protease Activities of Botulinum Neurotoxins, Serotypes A, B, and F by SCHMIDT, James J, STAFFORD, Robert G

“…ERRATUM ( vol. 69 , p. 3025 ) Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg…”
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Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A by Tang, Jing, Park, Jewn Giew, Millard, Charles B, Schmidt, James J, Pang, Yuan-Ping

“…Optimization of a serotype-selective, small-molecule inhibitor of botulinum neurotoxin serotype A (BoNTA) endopeptidase is a formidable challenge because the…”
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Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A by Park, Jewn Giew, Sill, Peter C., Makiyi, Edward F., Garcia-Sosa, Alfonso T., Millard, Charles B., Schmidt, James J., Pang, Yuan-Ping

“…Botulinum neurotoxin serotype A (BoNTA) is one of the most toxic substances known. Currently, there is no antidote to BoNTA. Small molecules identified from…”
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Use of a Recombinant Fluorescent Substrate with Cleavage Sites for All Botulinum Neurotoxins in High-Throughput Screening of Natural Product Extracts for Inhibitors of Serotypes A, B, and E by Hines, Harry B, Kim, Alexander D, Stafford, Robert G, Badie, Shirin S, Brueggeman, Ernst E, Newman, David J, Schmidt, James J

“…The seven serotypes of botulinum neurotoxin (BoNTs) are zinc metalloproteases that cleave and inactivate proteins critical for neurotransmission. The…”
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Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore by Hermone, Ann R., Burnett, James C., Nuss, Jonathan E., Tressler, Lyal E., Nguyen, Tam L., Šolaja, Bogdan A., Vennerstrom, Jonathan L., Schmidt, James J., Wipf, Peter, Bavari, Sina, Gussio, Rick

“…A search query consisting of two aromatic centers and two cationic centers was defined based on previously identified small molecule inhibitors of the…”
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Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F by Swaminathan, Subramanyam, Agarwal, Rakhi, Stafford, Robert G, Schmidt, James J

“…Clostridium botulinum neurotoxins (BoNTs) cleave proteins involved in neurotransmitter release, with different serotypes showing distinct cleavage specificity…”
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Targeted delivery into motor nerve terminals of inhibitors for SNARE‐cleaving proteases via liposomes coupled to an atoxic botulinum neurotoxin by Edupuganti, Om P., Ovsepian, Saak V., Wang, Jiafu, Zurawski, Tomas H., Schmidt, James J., Smith, Leonard, Lawrence, Gary W., Dolly, J. Oliver

“…A targeted drug carrier (TDC) is described for transferring functional proteins or peptides into motor nerve terminals, a pivotal locus for therapeutics to…”
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Rapid product analysis and increased sensitivity for quantitative determinations of botulinum neurotoxin proteolytic activity by Rowe, Benjamin, Schmidt, James J., Smith, Leonard A., Ahmed, S. Ashraf

“…The ultimate molecular action of botulinum neurotoxin (BoNT) is a Zn-dependent endoproteolytic activity on one of the three SNARE (soluble…”
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A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate by Zuniga, Jorge E., Schmidt, James J., Fenn, Timothy, Burnett, James C., Araç, Demet, Gussio, Rick, Stafford, Robert G., Badie, Shirin S., Bavari, Sina, Brunger, Axel T.

“…Botulinum neurotoxin serotype A is the most lethal of all known toxins. Here, we report the crystal structure, along with SAR data, of the zinc metalloprotease…”
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A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity by Schmidt, James J., Stafford, Robert G.

“…The peptide N-acetyl-CRATKML-amide is an effective inhibitor of type A botulinum neurotoxin (BoNT A) protease activity [Schmidt et al., FEBS Lett. 435 (1998)…”
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Botulinum Neurotoxin Serotype F:  Identification of Substrate Recognition Requirements and Development of Inhibitors with Low Nanomolar Affinity by Schmidt, James J, Stafford, Robert G

“…Botulinum neurotoxins (BoNTs A−G) are zinc metalloendoproteases that exhibit extraordinary specificities for proteins involved in neurotransmitter release. In…”
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A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease by Burnett, James C, Opsenica, Dejan, Sriraghavan, Kamaraj, Panchal, Rekha G, Ruthel, Gordon, Hermone, Ann R, Nguyen, Tam L, Kenny, Tara A, Lane, Douglas J, McGrath, Connor F, Schmidt, James J, Vennerstrom, Jonathan L, Gussio, Rick, Šolaja, Bogdan A, Bavari, Sina

“…We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain…”
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Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity by Burnett, James C, Schmidt, James J, Stafford, Robert G, Panchal, Rekha G, Nguyen, Tam L, Hermone, Ann R, Vennerstrom, Jonathan L, McGrath, Connor F, Lane, Douglas J, Sausville, Edward A, Zaharevitz, Daniel W, Gussio, Rick, Bavari, Sina

“…Botulinum neurotoxins (BoNTs) are among the most lethal biological substances to have been weaponized and are listed as biodefense category A agents…”
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High-Throughput Assays for Botulinum Neurotoxin Proteolytic Activity: Serotypes A, B, D, and F by Schmidt, James J., Stafford, Robert G., Millard, Charles B.

“…Botulinum neurotoxins (BoNT) are zinc metalloproteases that cleave and inactivate cellular proteins essential for neurotransmitter release. Because the…”
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Peptide-Toxin Tools for Probing the Expression and Function of Fetal and Adult Subtypes of the Nicotinic Acetylcholine Receptor by Teichert, Russell W., Garcia, Carmen C., Potian, Joseph G., Schmidt, James J., Witzemann, Veit, Olivera, Baldomero M., McArdle, Joseph J.

“…Although the neuromuscular nicotinic acetylcholine receptor (nAChR) is one of the most intensively studied ion channels in the nervous system, the differential…”
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Conformational sampling of the botulinum neurotoxin serotype a light chain: implications for inhibitor binding by Burnett, James C., Schmidt, James J., McGrath, Connor F., Nguyen, Tam L., Hermone, Ann R., Panchal, Rekha G., Vennerstrom, Jonathan L., Kodukula, Krishna, Zaharevitz, Daniel W., Gussio, Rick, Bavari, Sina

“…Molecular dynamics simulations were used to explore how residue motion in and around the botulinum neurotoxin serotype A light chain (BoNT/A LC) substrate…”
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Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A by Merino, Isidro, Thompson, Jason D., Millard, Charles B., Schmidt, James J., Pang, Yuan-Ping

“…Botulinum neurotoxin serotype A (BoNTA) is highly toxic, and its antidote is currently unavailable. The essential light-chain subunit of BoNTA is a zinc…”
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