Search Results - "Schmidt, Eric F."

Analytical approaches to RNA profiling data for the identification of genes enriched in specific cells by Dougherty, Joseph D, Schmidt, Eric F, Nakajima, Miho, Heintz, Nathaniel

“…We have recently developed a novel method for the affinity purification of the complete suite of translating mRNA from genetically labeled cell populations…”
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Serotonin receptor 4 in the hippocampus modulates mood and anxiety by Karayol, Remzi, Medrihan, Lucian, Warner-Schmidt, Jennifer L., Fait, Ben W., Rao, Meghana N., Holzner, Eva B., Greengard, Paul, Heintz, Nathaniel, Schmidt, Eric F.

“…Serotonin receptor 4 (5-HT 4 R) plays an important role in regulating mood, anxiety, and cognition, and drugs that activate this receptor have fast-acting…”
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Identification of the Cortical Neurons that Mediate Antidepressant Responses by Schmidt, Eric F., Warner-Schmidt, Jennifer L., Otopalik, Benjamin G., Pickett, Sarah B., Greengard, Paul, Heintz, Nathaniel

“…Our understanding of current treatments for depression, and the development of more specific therapies, is limited by the complexity of the circuits…”
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Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types by Doyle, Joseph P., Dougherty, Joseph D., Heiman, Myriam, Schmidt, Eric F., Stevens, Tanya R., Ma, Guojun, Bupp, Sujata, Shrestha, Prerana, Shah, Rajiv D., Doughty, Martin L., Gong, Shiaoching, Greengard, Paul, Heintz, Nathaniel

“…Comparative analysis can provide important insights into complex biological systems. As demonstrated in the accompanying paper, translating ribosome affinity…”
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A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice by Marrocco, Jordan, Petty, Gordon H., Ríos, Mariel B., Gray, Jason D., Kogan, Joshua F., Waters, Elizabeth M., Schmidt, Eric F., Lee, Francis S., McEwen, Bruce S.

“…Males and females use distinct brain circuits to cope with similar challenges. Using RNA sequencing of ribosome-bound mRNA from hippocampal CA3 neurons, we…”
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Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL by Linden, Jennifer R, Flores, Claudia, Schmidt, Eric F, Uzal, Francisco A, Michel, Adam O, Valenzuela, Marissa, Dobrow, Sebastian, Vartanian, Timothy

“…Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted…”
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Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior by Warner-Schmidt, Jennifer L, Schmidt, Eric F, Marshall, John J, Rubin, Amanda J, Arango-Lievano, Margarita, Kaplitt, Michael G, Ibañez-Tallon, Ines, Heintz, Nathaniel, Greengard, Paul

“…A large number of studies have demonstrated that the nucleus accumbens (NAC) is a critical site in the neuronal circuits controlling reward responses,…”
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Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA by Warner-Schmidt, Jennifer, Stogniew, Martin, Mandell, Blake, Rowland, R Scott, Schmidt, Eric F, Kelmendi, Benjamin

“…Post-traumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder that can become chronic and debilitating when left untreated. Available…”
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Rapid Molecular Profiling of Defined Cell Types Using Viral TRAP by Nectow, Alexander R., Moya, Maria V., Ekstrand, Mats I., Mousa, Awni, McGuire, Kelly L., Sferrazza, Caroline E., Field, Bianca C., Rabinowitz, Gabrielle S., Sawicka, Kirsty, Liang, Yupu, Friedman, Jeffrey M., Heintz, Nathaniel, Schmidt, Eric F.

“…Translational profiling methodologies enable the systematic characterization of cell types in complex tissues, such as the mammalian brain, where neuronal…”
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Early Life Stress Restricts Translational Reactivity in CA3 Neurons Associated With Altered Stress Responses in Adulthood by Marrocco, Jordan, Gray, Jason D, Kogan, Joshua F, Einhorn, Nathan R, O'Cinneide, Emma M, Rubin, Todd G, Carroll, Thomas S, Schmidt, Eric F, McEwen, Bruce S

“…Early life experiences program brain structure and function and contribute to behavioral endophenotypes in adulthood. Epigenetic control of gene expression by…”
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Unique molecular features and cellular responses differentiate two populations of motor cortical layer 5b neurons in a preclinical model of ALS by Moya, Maria V., Kim, Rachel D., Rao, Meghana N., Cotto, Bianca A., Pickett, Sarah B., Sferrazza, Caroline E., Heintz, Nathaniel, Schmidt, Eric F.

“…Many neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), lead to the selective degeneration of discrete cell types in the CNS despite the…”
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BAC transgenic mice and the GENSAT database of engineered mouse strains by Schmidt, Eric F, Kus, Laura, Gong, Shiaoching, Heintz, Nathaniel

“…The brain is a complex tissue comprising hundreds of distinct cell types, each of which has unique circuitry and plays a discrete role in nervous system…”
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RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors by Togashi, Hideaki, Schmidt, Eric F, Strittmatter, Stephen M

“…Secreted Semaphorin3A (Sema3A) proteins are known to act as diffusible and repellant axonal guidance cues during nervous system development. A receptor complex…”
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Serotonergic Suppression of Mouse Prefrontal Circuits Implicated in Task Attention by Tian, Michael K, Schmidt, Eric F, Lambe, Evelyn K

“…Serotonin (5-HT) regulates attention by neurobiological mechanisms that are not well understood. Layer 6 (L6) pyramidal neurons of prefrontal cortex play an…”
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Structural bases for CRMP function in plexin-dependent semaphorin3A signaling by Deo, Rahul C, Schmidt, Eric F, Elhabazi, Abdellah, Togashi, Hideaki, Burley, Stephen K, Strittmatter, Stephen M

“…Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown…”
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Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis by Roussarie, Jean-Pierre, Yao, Vicky, Rodriguez-Rodriguez, Patricia, Oughtred, Rose, Rust, Jennifer, Plautz, Zakary, Kasturia, Shirin, Albornoz, Christian, Wang, Wei, Schmidt, Eric F., Dannenfelser, Ruth, Tadych, Alicja, Brichta, Lars, Barnea-Cramer, Alona, Heintz, Nathaniel, Hof, Patrick R., Heiman, Myriam, Dolinski, Kara, Flajolet, Marc, Troyanskaya, Olga G., Greengard, Paul

“…A major obstacle to treating Alzheimer’s disease (AD) is our lack of understanding of the molecular mechanisms underlying selective neuronal vulnerability, a…”
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Common and divergent pathways in early stages of glutamate and tau-mediated toxicities in neurodegeneration by Chongtham, Anjalika, Sharma, Abhijeet, Nath, Banshi, Murtha, Kaitlin, Gorbachev, Kirill, Ramakrishnan, Aarthi, Schmidt, Eric F., Shen, Li, Pereira, Ana C.

“…It has been shown that excitotoxicity and tau-mediated toxicities are major contributing factors to neuronal death in Alzheimer's disease (AD). The excitatory…”
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RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine by Mitsi, Vasiliki, Ruiz, Anne, Polizu, Claire, Farzinpour, Zahra, Ramakrishnan, Aarthi, Serafini, Randal A, Parise, Eric M, Floodstrand, Madeline, Sial, Omar K, Gaspari, Sevasti, Tang, Cheuk Y, Nestler, Eric J, Schmidt, Eric F, Shen, Li, Zachariou, Venetia

“…The signal transduction protein, regulator of G protein signaling 4 (RGS4), plays a prominent role in physiologic and pharmacological responses by controlling…”
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The CRMP family of proteins and their role in Sema3A signaling by Schmidt, Eric F, Strittmatter, Stephen M

“…The CRMP proteins were originally identified as mediators of Sema3A signaling and neuronal differentiation. Much has been learned about the mechanism by which…”
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Cell-Type Specific Properties of Pyramidal Neurons in Neocortex Underlying a Layout that Is Modifiable Depending on the Cortical Area by Groh, Alexander, Meyer, Hanno S., Schmidt, Eric F., Heintz, Nathaniel, Sakmann, Bert, Krieger, Patrik

“…To understand sensory representation in cortex, it is crucial to identify its constituent cellular components based on cell-type–specific criteria. With the…”
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