Search Results - "Schmidt, E R"

Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells by Lin, H, Stankov, M V, Hegermann, J, Budida, R, Panayotova-Dimitrova, D, Schmidt, R E, Behrens, G M N

“…Nucleoside reverse transcriptase inhibitors (NRTI), such as zidovudine (AZT), are constituents of HIV-1 therapy and are used for the prevention of…”
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Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis by RIGGS, A. C, BERNAL-MIZRACHI, E, OHSUGI, M, WASSON, J, FATRAI, S, WELLING, C, MURRAY, J, SCHMIDT, R. E, HERRERA, P. L, PERMUTT, M. A

“…Wolfram syndrome is an autosomal recessive disorder characterised by childhood diabetes mellitus, optic atrophy and severe neurodegeneration, resulting in…”
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dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients by Manitt, C, Eng, C, Pokinko, M, Ryan, R T, Torres-Berrío, A, Lopez, J P, Yogendran, S V, Daubaras, M J J, Grant, A, Schmidt, E R E, Tronche, F, Krimpenfort, P, Cooper, H M, Pasterkamp, R J, Kolb, B, Turecki, G, Wong, T P, Nestler, E J, Giros, B, Flores, C

“…Adolescence is a period of heightened susceptibility to psychiatric disorders of medial prefrontal cortex (mPFC) dysfunction and cognitive impairment. mPFC…”
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Recurrent, Multifocal Mycobacterium avium-intercellulare Infection in a Patient with Interferon-γ Autoantibody by Baerlecken, N., Jacobs, R., Stoll, M., Schmidt, R. E., Witte, T.

“…We describe a patient who experienced severe osteomyelitis because of Mycobacterium avium-intercellulare infection and high-titered autoantibodies against…”
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Genetic Mechanisms Underlying the Evolution of Connectivity in the Human Cortex by Schmidt, Ewoud R E, Polleux, Franck

“…One of the most salient features defining modern humans is our remarkable cognitive capacity, which is unrivaled by any other species. Although we still lack a…”
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Severe acute neurotoxicity reflects absolute intra-carotid 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine dose in non-human primates by Norris, SA, White, HCB, Tanenbaum, A., Williams, EL, Cruchaga, C., Tian, L., Schmidt, RE, Perlmutter, JS

“…•Absolute MPTP dose differed with acute recovery versus severe acute neurotoxicity.•Body weight and mean brain volume did not differ across outcome…”
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The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development by Schmidt, Ewoud R. E., Kupferman, Justine V., Stackmann, Michelle, Polleux, Franck

“…Human-specific gene duplications (HSGDs) have recently emerged as key modifiers of brain development and evolution. However, the molecular mechanisms…”
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Current state of evidence on ‘off-label’ therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria and Switzerland – a consensus report by Aringer, M, Burkhardt, H, Burmester, GR, Fischer-Betz, R, Fleck, M, Graninger, W, Hiepe, F, Jacobi, AM, Kötter, I, Lakomek, HJ, Lorenz, HM, Manger, B, Schett, G, Schmidt, RE, Schneider, M, Schulze-Koops, H, Smolen, JS, Specker, C, Stoll, T, Strangfeld, A, Tony, HP, Villiger, PM, Voll, R, Witte, T, Dörner, T

“…Systemic lupus erythematosus (SLE) can be a severe and potentially life-threatening disease that often represents a therapeutic challenge because of its…”
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Remotely Produced and Axon-Derived Netrin-1 Instructs GABAergic Neuron Migration and Dopaminergic Substantia Nigra Development by Brignani, Sara, Raj, Divya D.A., Schmidt, Ewoud R.E., Düdükcü, Özge, Adolfs, Youri, De Ruiter, Anna A., Rybiczka-Tesulov, Mateja, Verhagen, Marieke G., van der Meer, Christiaan, Broekhoven, Mark H., Moreno-Bravo, Juan A., Grossouw, Laurens M., Dumontier, Emilie, Cloutier, Jean-François, Chédotal, Alain, Pasterkamp, R. Jeroen

“…The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviors and show select disease…”
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Hormone‐Containing Products' Impact on Antioxidant Status of Tall Fescue and Creeping Bentgrass Subjected to Drought by Zhang, Xunzhong, Schmidt, R. E.

“…This study was conducted to determine whether the plant endogenous antioxidant concentration is responsive to exogenous hormone‐containing products (HCPs) in…”
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A double hit implicates DIAPH3 as an autism risk gene by Vorstman, J A S, van Daalen, E, Jalali, G R, Schmidt, E R E, Pasterkamp, R J, de Jonge, M, Hennekam, E A M, Janson, E, Staal, W G, van der Zwaag, B, Burbach, J P H, Kahn, R S, Emanuel, B S, van Engeland, H, Ophoff, R A

“…Recent studies have shown that more than 10% of autism cases are caused by de novo structural genomic rearrangements. Given that some heritable copy number…”
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A human-specific modifier of cortical connectivity and circuit function by Schmidt, Ewoud R. E., Zhao, Hanzhi T., Park, Jung M., Dipoppa, Mario, Monsalve-Mercado, Mauro M., Dahan, Jacob B., Rodgers, Chris C., Lejeune, Amélie, Hillman, Elizabeth M. C., Miller, Kenneth D., Bruno, Randy M., Polleux, Franck

“…The cognitive abilities that characterize humans are thought to emerge from unique features of the cortical circuit architecture of the human brain, which…”
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Plant Growth Regulators Can Enhance the Recovery of Kentucky Bluegrass Sod from Heat Injury by Zhang, Xunzhong, Ervin, E. H., Schmidt, R. E.

“…A primary economic concern of sod producers is loss of sod quality during the transportation, storage, and transplant stages of sale. Although a number of…”
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Large vessel vasculitis and spondyloarthritis: coincidence or associated diseases? by Ernst, D, Baerlecken, NT, Schmidt, RE, Witte, T

“…Introduction: Although cardiac complications have been reported in established spondyloarthritis (SpA), little is known about peripheral axial SpA in large…”
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Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32) by Werwitzke, S, Trick, D, Sondermann, P, Kamino, K, Schlegelberger, B, Kniesch, K, Tiede, A, Jacob, U, Schmidt, R E, Witte, T

“…Systemic lupus erythematosus (SLE) is a classical autoimmune disorder characterised by the production of IgG autoantibodies against double-stranded DNA…”
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The IgG Fc receptor family by GESSNER, J. E, HEIKEN, H, TAMM, A, SCHMIDT, R. E

“…IgG immune complexes are of central importance in the humoral immune system and strongly implicated in the pathogenesis of hematologic and rheumatic autoimmune…”
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Outcomes of splenectomy in patients with common variable immunodeficiency (CVID): a survey of 45 patients by Wong, G. K., Goldacker, S., Winterhalter, C., Grimbacher, B., Chapel, H., Lucas, M., Alecsandru, D., McEwen, D., Quinti, I., Martini, H., Schmidt, R. E., Ernst, D., Espanol, T., Vidaller, A., Carbone, J., Fernandez‐Cruz, E., Lougaris, V., Plebani, A., Kutukculer, N., Gonzalez‐Granado, L. I., Contreras, R., Kiani‐Alikhan, S., Ibrahim, M. A. A., Litzman, J., Jones, A., Gaspar, H. B., Hammarstrom, L., Baumann, U., Warnatz, K., Huissoon, A. P.

“…Summary Splenectomy has been used in patients with common variable immunodeficiency disorders (CVID), mainly in the context of refractory autoimmune cytopenia…”
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Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers by Plant, Darren, Flynn, Edward, Mbarek, Hamdi, Dieudé, Philippe, Cornelis, François, Arlestig, Lisbeth, Dahlqvist, Solbritt Rantapää, Goulielmos, George, Boumpas, Dimitrios T, Sidiropoulos, Prodromos, Johansen, Julia S, Ørnbjerg, Lykke M, Hetland, Merete Lund, Klareskog, Lars, Filer, Andrew, Buckley, Christopher D, Raza, Karim, Witte, Torsten, Schmidt, Reinhold E, Worthington, Jane

“…Genetic factors have a substantial role in determining development of rheumatoid arthritis (RA), and are likely to account for 50-60% of disease…”
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unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model by Auger, Meagan L., Schmidt, Ewoud R. E., Manitt, Colleen, Dal-Bo, Greg, Pasterkamp, R. Jeroen, Flores, Cecilia

“…DCC and UNC5 homologs (UNC5H) are guidance cue receptors highly expressed by mesocorticolimbic dopamine neurons. We have shown that dcc heterozygous mice…”
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Impaired glucose tolerance, beta cell function and lipid metabolism in HIV patients under treatment with protease inhibitors by BEHRENS, G, DEJAM, A, SCHMIDT, H, BALKS, H.-J, BRABANT, G, KÖRNER, T, STOLL, M, SCHMIDT, R. E

“…To evaluate metabolic abnormalities, beta-cell function, lipid profile and vascular risk factors in HIV patients on protease inhibitors (PI). Prospective…”
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