Search Results - "Schmidt, Dawn M. Z"

trans-2-Phenylcyclopropylamine Is a Mechanism-Based Inactivator of the Histone Demethylase LSD1 by Schmidt, Dawn M. Z, McCafferty, Dewey G

“…The catalytic domain of the flavin-dependent human histone demethylase lysine-specific demethylase 1 (LSD1) belongs to the family of amine oxidases including…”
Get full text

Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B by Gooden, David M., Schmidt, Dawn M.Z., Pollock, Julie A., Kabadi, Ami M., McCafferty, Dewey G.

“…A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide mechanism-based inhibitors of the flavoenzyme histone…”
Get full text

Evolutionary Potential of (β/α)8-Barrels:  Functional Promiscuity Produced by Single Substitutions in the Enolase Superfamily by Schmidt, Dawn M. Z, Mundorff, Emily C, Dojka, Michael, Bermudez, Ericka, Ness, Jon E, Govindarajan, Sridhar, Babbitt, Patricia C, Minshull, Jeremy, Gerlt, John A

“…The members of the mechanistically diverse, (β/α)8-barrel fold-containing enolase superfamily evolved from a common progenitor but catalyze different reactions…”
Get full text

Use of pH and Kinetic Isotope Effects To Establish Chemistry as Rate-Limiting in Oxidation of a Peptide Substrate by LSD1 by Gaweska, Helena, Henderson Pozzi, Michelle, Schmidt, Dawn M. Z, McCafferty, Dewey G, Fitzpatrick, Paul F

“…The mechanism of oxidation of a peptide substrate by the flavoprotein lysine-specific demethylase (LSD1) has been examined using the effects of pH and isotopic…”
Get full text

Evolutionary Potential of (β/α)8-Barrels:  In Vitro Enhancement of a “New” Reaction in the Enolase Superfamily by Vick, Jacob E, Schmidt, Dawn M. Z, Gerlt, John A

“…The repertoire of reactions in the mechanistically diverse enolase superfamily is the result of divergent evolution that conserved enolization of a carboxylate…”
Get full text

Evolution of Enzymatic Activities in the Enolase Superfamily:  Functional Assignment of Unknown Proteins in Bacillus subtilis and Escherichia coli as l-Ala-d/l-Glu Epimerases by Schmidt, Dawn M. Z, Hubbard, Brian K, Gerlt, John A

“…The members of the mechanistically diverse enolase superfamily catalyze different overall reactions by using a common catalytic strategy and structural…”
Get full text

Evolution of Enzymatic Activities in the Enolase Superfamily:  Crystal Structures of the l-Ala-d/l-Glu Epimerases from Escherichia coli and Bacillus subtilis by Gulick, Andrew M, Schmidt, Dawn M. Z, Gerlt, John A, Rayment, Ivan

“…The members of the enolase superfamily catalyze different overall reactions, yet share a partial reaction that involves Mg2+-assisted enolization of the…”
Get full text

Chemical and Enzymatic Synthesis of Fluorinated-Dehydroalanine-Containing Peptides by Zhou, Hao, Schmidt, Dawn M.Z, Gerlt, John A, van der Donk, Wilfred A

“…Michael acceptors have long been recognized as reactive functionalities that may link a biologically active molecule to its cellular target. 1,2-Dehydro amino…”
Get full text