Search Results - "Schmidt, Amanda M"

Continuous IL-23 stimulation drives ILC3 depletion in the upper GI tract and, in combination with TNFα, induces robust activation and a phenotypic switch of ILC3 by Paustian, Amanda M Schmidt, Paez-Cortez, Jesus, Bryant, Shaughn, Westmoreland, Susan, Waegell, Wendy, Kingsbury, Gillian

“…Mutations in the Interleukin (IL)-23/IL-23 receptor loci are associated with increased inflammatory bowel disease (IBD) susceptibility, and IL-23…”
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Inhibition of calcineurin abrogates while inhibition of mTOR promotes regulatory T cell expansion and graft-versus-host disease protection by IL-2 in allogeneic bone marrow transplantation by Satake, Atsushi, Schmidt, Amanda M, Nomura, Shosaku, Kambayashi, Taku

“…Regulatory T cells (Treg)s attenuate excessive immune responses, making their expansion beneficial in immune-mediated diseases including allogeneic bone marrow…”
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Diacylglycerol Kinase ζ Is a Target To Enhance NK Cell Function by Yang, Enjun, Singh, Brenal K, Paustian, Amanda M Schmidt, Kambayashi, Taku

“…Enhancement of NK cell function could be beneficial in treatment of a variety of tumors and infections. However, efforts to improve NK cell function by…”
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A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens by Sindhava, Vishal J, Oropallo, Michael A, Moody, Krishna, Naradikian, Martin, Higdon, Lauren E, Zhou, Lin, Myles, Arpita, Green, Nathaniel, Nündel, Kerstin, Stohl, William, Schmidt, Amanda M, Cao, Wei, Dorta-Estremera, Stephanie, Kambayashi, Taku, Marshak-Rothstein, Ann, Cancro, Michael P

“…Mature B cell pools retain a substantial proportion of polyreactive and self-reactive clonotypes, suggesting that activation checkpoints exist to reduce the…”
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TCR signaling intensity controls CD8+ T cell responsiveness to TGF‐β by Arumugam, Vidhyalakshmi, Bluemn, Theresa, Wesley, Erin, Schmidt, Amanda M., Kambayashi, Taku, Malarkannan, Subramaniam, Riese, Matthew J.

“…Enhancing TCR signal strength can attenuate TGFβ‐mediated transcriptional changes and functions in CD8+ T cells, independent of changes to canonical TGFβ…”
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Regulatory T cells require TCR signaling for their suppressive function by Schmidt, Amanda M, Lu, Wen, Sindhava, Vishal J, Huang, Yanping, Burkhardt, Janis K, Yang, Enjun, Riese, Matthew J, Maltzman, Jonathan S, Jordan, Martha S, Kambayashi, Taku

“…Regulatory T cells (Tregs) are a subset of CD4(+) T cells that maintain immune tolerance in part by their ability to inhibit the proliferation of conventional…”
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Cell-autonomous role of TGFβ and IL-2 receptors in CD4+ and CD8+ inducible regulatory T-cell generation during GVHD by Sawamukai, Norifumi, Satake, Atsushi, Schmidt, Amanda M., Lamborn, Ian T., Ojha, Priti, Tanaka, Yoshiya, Kambayashi, Taku

“…FoxP3+ regulatory T cells (Tregs) suppress GVHD while preserving graft-versus-tumor effects, making them an attractive target for GVHD therapy. The…”
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The ζ isoform of diacylglycerol kinase plays a predominant role in regulatory T cell development and TCR-mediated ras signaling by Joshi, Rohan P, Schmidt, Amanda M, Das, Jayajit, Pytel, Dariusz, Riese, Matthew J, Lester, Melissa, Diehl, J Alan, Behrens, Edward M, Kambayashi, Taku, Koretzky, Gary A

“…Diacylglycerol (DAG) is a critical second messenger that mediates T cell receptor (TCR)-stimulated signaling. The abundance of DAG is reduced by the…”
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Diacylglycerol kinase ζ limits the generation of natural regulatory T cells by Schmidt, Amanda M, Zou, Tao, Joshi, Rohan P, Leichner, Theresa M, Pimentel, Matthew A, Sommers, Connie L, Kambayashi, Taku

“…Natural regulatory T (nT(reg)) cells are important for maintaining tolerance to self- and foreign antigens, and they are thought to develop from thymocytes…”
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Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo by Zou, Tao, Satake, Atsushi, Corbo-Rodgers, Evann, Schmidt, Amanda M, Farrar, Michael A, Maltzman, Jonathan S, Kambayashi, Taku

“…To ensure immune tolerance, regulatory T cell (Treg) numbers must be maintained by cell division. This process has been thought to be strictly dependent on the…”
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Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells by Satake, Atsushi, Schmidt, Amanda M, Archambault, Angela, Leichner, Theresa M, Wu, Gregory F, Kambayashi, Taku

“…Abstract Strategies to expand regulatory T cells hold therapeutic potential for ameliorating T cell-mediated autoimmunity. Recently, we reported that the…”
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Continuous IL-23 stimulation drives ILC3 depletion in the upper GI tract and, in combination with TNF[alpha], induces robust activation and a phenotypic switch of ILC3 by Paustian, Amanda M. Schmidt, Paez-Cortez, Jesus, Bryant, Shaughn, Westmoreland, Susan, Waegell, Wendy, Kingsbury, Gillian

“…Mutations in the Interleukin (IL)-23/IL-23 receptor loci are associated with increased inflammatory bowel disease (IBD) susceptibility, and IL-23…”
Get full text

A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens by Sindhava, Vishal J, Oropallo, Michael A, Moody, Krishna, Naradikian, Martin, Higdon, Lauren E, Zhou, Lin, Myles, Arpita, Green, Nathaniel, Nundel, Kerstin, Stohl, William, Schmidt, Amanda M, Cao, Wei, Dorta-Estremera, Stephanie, Kambayashi, Taku, Marshak-Rothstein, Ann, Cancro, Michael P

“…Mature B cell pools retain a substantial proportion of polyreactive and self-reactive donotypes, suggestingthat activation checkpoints exist to reduce the…”
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Differential Targeting of Signaling Pathways to Selectively Expand Mouse Regulatory T Cells While Inhibiting Conventional T Cells by Satake, Atsushi, Schmidt, Amanda M, Archambault, Angela, Wu, Gregory F, Kambayashi, Taku

“…Abstract 2158 Regulatory T cells (Tregs) are suppressive T cells with therapeutic potential for ameliorating T cell-mediated diseases. Thus, there has been…”
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Inhibition of Calcineurin Abrogates While Inhibition of mTOR Promotes Regulatory T Cell Expansion and Graft-Versus-Host Disease Protection by IL-2 in Allogeneic Bone Marrow Transplantation: e92888 by Satake, Atsushi, Schmidt, Amanda M, Nomura, Shosaku, Kambayashi, Taku

“…Regulatory T cells (Treg)s attenuate excessive immune responses, making their expansion beneficial in immune-mediated diseases including allogeneic bone marrow…”
Get full text

Diacylglycerol Kinase ζ is a target to enhance natural killer cell function1 by Yang, Enjun, Singh, Brenal K., Schmidt Paustian, Amanda M., Kambayashi, Taku

“…Enhancement of natural killer (NK) cell function could be beneficial in treatment of a variety of tumors and infections. However, efforts to improve NK cell…”
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The role of proximal T cell receptor signal transduction in regulatory T cell development and function by Schmidt, Amanda M

“…Regulatory T cells (Tregs) are required to maintain peripheral tolerance within the adaptive immune system. nTregs are thought to require strong TCR-mediated…”
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