Search Results - "Schmidlin, Heike"

Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B by Nagasawa, Maho, Schmidlin, Heike, Hazekamp, Mark G, Schotte, Remko, Blom, Bianca

“…Plasmacytoid dendritic cells (pDC) are central players in the innate and adaptive immune response against viral infections. The molecular mechanism that…”
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The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1 by Karrich, Julien J., Balzarolo, Melania, Schmidlin, Heike, Libouban, Marion, Nagasawa, Maho, Gentek, Rebecca, Kamihira, Shimeru, Maeda, Takahiro, Amsen, Derk, Wolkers, Monika C., Blom, Bianca

“…Plasmacytoid dendritic cells (pDCs) selectively express Toll-like receptor (TLR)–7 and TLR-9, which allow them to rapidly secrete massive amounts of type I…”
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Spi-B inhibits human plasma cell differentiation by repressing BLIMP1 and XBP-1 expression by Schmidlin, Heike, Diehl, Sean A., Nagasawa, Maho, Scheeren, Ferenc A., Schotte, Remko, Uittenbogaart, Christel H., Spits, Hergen, Blom, Bianca

“…The terminal differentiation of B cells into antibody-secreting plasma cells is tightly regulated by a complex network of transcription factors. Here we…”
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New insights in the regulation of human B cell differentiation by Schmidlin, Heike, Diehl, Sean A., Blom, Bianca

“…B lymphocytes provide the cellular basis of the humoral immune response. All stages of this process, from B cell activation to formation of germinal centers…”
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IL‐6 Triggers IL‐21 production by human CD4+ T cells to drive STAT3‐dependent plasma cell differentiation in B cells by Diehl, Sean A, Schmidlin, Heike, Nagasawa, Maho, Blom, Bianca, Spits, Hergen

“…Interleukin (IL)‐21‐producing CD4+T cells are central to humoral immunity. Deciphering the signals that induce IL‐21 production in CD4+ T cells and those…”
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STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation by Diehl, Sean A, Schmidlin, Heike, Nagasawa, Maho, van Haren, Simon D, Kwakkenbos, Mark J, Yasuda, Etsuko, Beaumont, Tim, Scheeren, Ferenc A, Spits, Hergen

“…STAT family members have been implicated in regulating the balance between B cell lymphoma (BCL)6 and B lymphocyte induced maturation protein (BLIMP)1 to…”
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New insights into the regulation of human B-cell differentiation by Schmidlin, Heike, Diehl, Sean A, Blom, Bianca

“…B lymphocytes provide the cellular basis of the humoral immune response. All stages of this process, from B-cell activation to formation of germinal centers…”
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Isolation and in vitro generation of gene-manipulated human plasmacytoid and conventional dendritic cells by Schotte, Remko, Schmidlin, Heike, Nagasawa, Maho, Dontje, Wendy, Karrich, Julien J, Uittenbogaart, Christel, Spits, Hergen, Blom, Bianca

“…Our understanding of human lymphocyte development has increased significantly over the past 20 years. In particular, our insight into human T- and B-cell…”
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GSI-1, a Putative Notch Inhibitor, Induces Apoptosis in B-CLL Cells Via Proteasomal Inhibition and Noxa Upregulation by Hallaert, Delfine Y.H., Schmidlin, Heike, Eldering, Eric, Van Oers, Marinus H.J.

“…Mainly based on the observation that overexpression of CD23 in B-CLL cells is regulated by Notch2, deregulation of the Notch pathway has been suggested to…”
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Spi-B inhibits human plasma cell differentiation by repressing BLIMP 1 and XBP-1 expression by SCHMIDLIN, Heike, DIEHL, Sean A, NAGASAWA, Maho, SCHEEREN, Ferenc A, SCHOTTE, Remko, UITTENBOGAART, Christel H, SPITS, Hergen, BLOM, Bianca

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STAT3-Mediated Up-Regulation of BLIMP1 Is Coordinated with BCL6 Down-Regulation to Control Human Plasma Cell Differentiation1 by Diehl, Sean A., Schmidlin, Heike, Nagasawa, Maho, van Haren, Simon D., Kwakkenbos, Mark J., Yasuda, Etsuko, Beaumont, Tim, Scheeren, Ferenc A., Spits, Hergen

“…STAT family members have been implicated in regulating the balance between B cell lymphoma (BCL)6 and B lymphocyte induced maturation protein (BLIMP)1 to…”
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On the Relevance of TCR Rearrangement Circles as Molecular Markers for Thymic Output during Experimental Graft-versus-Host Disease by Krenger, Werner, Schmidlin, Heike, Cavadini, Gionata, Hollander, Georg A

“…Efficient reconstitution of the pool of peripheral T cells after hemopoietic stem cell transplantation (HSCT) is dependent on normal thymic function. However,…”
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Stimulated plasmacytoid dendritic cells impair human T-cell development by Schmidlin, Heike, Dontje, Wendy, Groot, Fedde, Ligthart, Suzanne J., Colantonio, Arnaud D., Oud, Monique E., Schilder-Tol, Esther J., Spaargaren, Marcel, Spits, Hergen, Uittenbogaart, Christel H., Blom, Bianca

“…Thymic plasmacytoid dendritic cells (pDCs) are located predominantly in the medulla and at the corticomedullary junction, the entry site of bone marrow–derived…”
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