Search Results - "Schmidlin, Cody J"

Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis by Anandhan, Annadurai, Dodson, Matthew, Schmidlin, Cody J, Liu, Pengfei, Zhang, Donna D

“…Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation dependent. As new mechanistic insight into ferroptotic…”
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Modulating NRF2 in Disease: Timing Is Everything by Dodson, Matthew, de la Vega, Montserrat Rojo, Cholanians, Aram B, Schmidlin, Cody J, Chapman, Eli, Zhang, Donna D

“…The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central regulator of redox, metabolic, and protein homeostasis that…”
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Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2–related factors 1 and 2 (NRF1 and NRF2) by Tian, Wang, Rojo de la Vega, Montserrat, Schmidlin, Cody J., Ooi, Aikseng, Zhang, Donna D.

“…Nuclear factor erythroid-2–related factor 1 (NRF1) and NRF2 are essential for maintaining redox homeostasis and coordinating cellular stress responses. They…”
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Filtering through the role of NRF2 in kidney disease by Schmidlin, Cody J., Dodson, Matthew B., Zhang, Donna D.

“…Kidney disease affects ~ 10% of the population worldwide, resulting in millions of deaths each year. Mechanistically, oxidative stress is a major driver of…”
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The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis by Liu, Pengfei, Luo, Gang, Dodson, Matthew, Schmidlin, Cody J., Wei, Yongyi, Kerimoglu, Baris, Ooi, Aikseng, Chapman, Eli, Garcia, Joe GN, Zhang, Donna D.

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible disease characterized by an increase in differentiation of fibroblasts to myofibroblasts…”
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Activation of NRF2 by topical apocarotenoid treatment mitigates radiation-induced dermatitis by Schmidlin, Cody J., Rojo de la Vega, Montserrat, Perer, Jessica, Zhang, Donna D., Wondrak, Georg T.

“…Radiation therapy is a frontline treatment option for cancer patients; however, the effects of radiotherapy on non-tumor tissue (e.g. radiation-induced…”
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CHML is an NRF2 target gene that regulates mTOR function by Dodson, Matthew, Dai, Wujing, Anandhan, Annadurai, Schmidlin, Cody J., Liu, Pengfei, Wilson, Nathan C., Wei, Yongyi, Kitamura, Naoya, Galligan, James J., Ooi, Aikseng, Chapman, Eli, Zhang, Donna D.

“…The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is often highly expressed in non‐small cell lung cancer (NSCLC). Through its target…”
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Redox regulation by NRF2 in aging and disease by Schmidlin, Cody J., Dodson, Matthew B., Madhavan, Lalitha, Zhang, Donna D.

“…NRF2, a transcription factor that has been deemed the master regulator of cellular redox homeostasis, declines with age. NRF2 transcriptionally upregulates…”
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Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism by Liu, Pengfei, Dodson, Matthew, Li, Hui, Schmidlin, Cody J., Shakya, Aryatara, Wei, Yongyi, Garcia, Joe G.N., Chapman, Eli, Kiela, Pawel R., Zhang, Qing-Yu, White, Eileen, Ding, Xinxin, Ooi, Aikseng, Zhang, Donna D.

“…NRF2, a transcription factor that regulates cellular redox and metabolic homeostasis, plays a dual role in human disease. While it is well known that canonical…”
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The intricacies of NRF2 regulation in cancer by Schmidlin, Cody J., Shakya, Aryatara, Dodson, Matthew, Chapman, Eli, Zhang, Donna D.

“…The complex role of NRF2 in the context of cancer continues to evolve. As a transcription factor, NRF2 regulates various genes involved in redox homeostasis,…”
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FAM129B‐dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells by Schmidlin, Cody J., Tian, Wang, Dodson, Matthew, Chapman, Eli, Zhang, Donna D.

“…Incidence of melanoma continues to rise in the United States with ~100,000 new cases diagnosed in 2019. While the 5‐year survival rate of melanoma is 99% when…”
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Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9 by Schmidlin, Cody J., Zeng, Tao, Liu, Pengfei, Wei, Yongyi, Dodson, Matthew, Chapman, Eli, Zhang, Donna D.

“…Chronic low dose arsenic exposure continues to be a worldwide health concern because of its prevalence and link to increased cancer risk, including non-small…”
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Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78 by Ambrose, Andrew J., Sivinski, Jared, Zerio, Christopher J., Zhu, Xiaoyi, Godek, Jack, Kumirov, Vlad K., Coma Brujas, Teresa, Torra Garcia, Joan, Annadurai, Anandhan, Schmidlin, Cody J., Werner, Alyssa, Shi, Taoda, Zavareh, Reza Beheshti, Lairson, Luke, Zhang, Donna D., Chapman, Eli

“…A recent study illustrated that a fluorescence polarization assay can be used to identify substrate-competitive Hsp70 inhibitors that can be isoform-selective…”
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A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78 by Ambrose, Andrew J., Zerio, Christopher J., Sivinski, Jared, Schmidlin, Cody J., Shi, Taoda, Ross, Alison B., Widrick, Kimberly J., Johnson, Steven M., Zhang, Donna D., Chapman, Eli

“…Glucose-regulated protein 78 (GRP78) is the ER resident 70 kDa heat shock protein 70 (HSP70) and has been hypothesized to be a therapeutic target for various…”
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ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A by Tillotson, Joseph, Kedzior, Magdalena, Guimarães, Larissa, Ross, Alison B., Peters, Tara L., Ambrose, Andrew J., Schmidlin, Cody J., Zhang, Donna D., Costa-Lotufo, Letícia V., Rodríguez, Abimael D., Schatz, Jonathan H., Chapman, Eli

“…[Display omitted] Activation of translation initiation is a common trait of cancer cells. Formation of the heterotrimeric eukaryotic initiation factor F…”
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Filtering through the role of NRF3 in kidney disease by Cody J. Schmidlin, Matthew B. Dodson, Donna D. Zhang

“…Kidney disease affects * 10% of the populationworldwide, resulting in millions of deaths each year. Mechanistically, oxidative stress is a major driver of…”
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