Search Results - "Schmid, Steven M"

Anti-Endosialin Antibody-Drug Conjugate: Potential in Sarcoma and Other Malignancies by Rouleau, Cecile, Gianolio, Diego A, Smale, Robert, Roth, Stephanie D, Krumbholz, Roy, Harper, Jay, Munroe, Kenneth J, Green, Tessa L, Horten, Bruce C, Schmid, Steven M, Teicher, Beverly A

“…Endosialin/TEM1/CD248 is a cell surface protein expressed at high levels by the malignant cells of about 50% of sarcomas and neuroblastomas. The antibody-drug…”
Get full text

Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer Treatment by KURTZBERG, Leslie S, ROTH, Stephanie, FEI WANG, SCHMID, Steven M, LAVOIE, Edmond J, TEICHER, Beverly A, KRUMBHOLZ, Roy, CRAWFORD, Jennifer, BORMANN, Christy, DUNHAM, Sarah, MIN YAO, ROULEAU, Cecile, BAGLEY, Rebecca G, YU, Xian-Jie

“…Genz-644282 [8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate for…”
Get full text

Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents by Kurtzberg, Leslie S, Roth, Stephanie D, Bagley, Rebecca G, Rouleau, Cecile, Yao, Min, Crawford, Jennifer L, Krumbholz, Roy D, Schmid, Steven M, Teicher, Beverly A

“…Purpose The dynamic instability of microtubules in cells is one of the key targets of anticancer therapeutics. Microtubule-disrupting agents such as vinca…”
Get full text

Targeting HER2-positive cancer with dolastatin 15 derivatives conjugated to trastuzumab, novel antibody–drug conjugates by Gianolio, Diego A., Rouleau, Cecile, Bauta, William E., Lovett, Dennis, Cantrell, William R., Recio, Antonio, Wolstenholme-Hogg, Paul, Busch, Michelle, Pan, Peng, Stefano, James E., Kramer, Hildegard M., Goebel, James, Krumbholz, Roy D., Roth, Stephanie, Schmid, Steven M., Teicher, Beverly A.

“…Purpose Targeting tubulin binders to cancer cells using antibody–drug conjugates (ADCs) has great potential to become an effective cancer treatment with low…”
Get full text

Synthesis and Evaluation of Several New (2-Chloroethyl)nitrosocarbamates as Potential Anticancer Agents by Reynolds, Robert C, Tiwari, Anita, Harwell, Joyce E, Gordon, Deborah G, Garrett, Beverly D, Gilbert, Karen S, Schmid, Steven M, Waud, William R, Struck, Robert F

“…Seven new (2-chloroethyl)nitrosocarbamates have been synthesized as potential anticancer alkylating agents. These compounds were designed with carrier moieties…”
Get full text

The mechanism of action of docetaxel (Taxotere®) in xenograft models is not limited to bcl-2 phosphorylation by KRAUS, Lisa Ann, SAMUEL, Shanti K, SCHMID, Steven M, DYKES, Donald J, WAUD, William R, BISSERY, Marie Christine

“…Docetaxel is a new taxoid compound with a broad spectrum of antitumor activity. Previous studies have shown that in vitro treatment of specific human tumor…”
Get full text

4-demethylpenclomedine, an antitumor-active, potentially nonneurotoxic metabolite of penclomedine by WAUD, W. R, TIWARI, A, SCHMID, S. M, SHIH, T.-W, STRONG, J. M, HARTMAN, N. R, O'REILLY, S, STRUCK, R. F

“…Penclomedine [3,5-dichloro-4,6-dimethoxy-2-(trichloromethyl)pyridine], an antitumor agent, is currently in Phase I clinical trials and is believed to be a…”
Get full text

Abstract C220: Genz-644282, a non-camptothecin topoisomerase one inhibitor, demonstrates a wide spectrum of in vitro and in vivo antitumor activity by Roth, Stephanie, LaVoie, Edmond, O'Shea, Thomas, Fang, Rick, Kurtzberg, Leslie, Teicher, Beverly A., Schmid, Steven M., Krumbholz, Roy, Crawford, Jennifer, Bormann, Christy, Dunham, Sarah

“…Abstract Genz-644282 (GZ) is a novel non-camptothecin topoisomerase I (Top1) inhibitor. The in vitro and in vivo activity of GZ and its M1 and M2 metabolites…”
Get full text

Preclinical Antitumor Activity of 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine (C1-F-Ara-A) by Waud, William R., Schmid, Steven M., Montgomery, John A., Secrist, John A.

“…Cl-F-ara-A, an analog of fludarabine, was evaluated against a spectrum of tumor systems in culture and in mice. The compound exhibited significant cytotoxicity…”
Get full text

Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells by White, E L, Ross, L J, Schmid, S M, Kelloff, G J, Steele, V E, Hill, D L

“…With BRL 3A hepatocytes, a series of selected, potentially chemopreventive chemicals was evaluated for their capacity to elevate glutathione (GSH) levels…”
Get more information

Screening of potential cancer-preventing chemicals for inhibition of induction of ornithine decarboxylase in epithelial cells from rat trachea by White, E L, Ross, L J, Schmid, S M, Kelloff, G J, Steele, V E, Hill, D L

“…Sixty-one selected chemicals were evaluated in rat tracheal epithelial (2C5) cells for their capacity to inhibit induction (or inhibit directly) the enzyme…”
Get more information

Antitumor activity of halogen analogs of phosphoramide, isophosphoramide, and triphosphoramide mustards, the cytotoxic metabolites of cyclophosphamide, ifosfamide, and trofosfamide by STRUCK, R. F, SCHMID, S. M, WAUD, W. R

“…A series of halogen analogs of phosphoramide mustard, isophosphoramide mustard, and triphosphoramide mustard, the cytotoxic metabolites of the antitumor drugs…”
Get full text

In vitro modulation of antioxidant enzymes in normal and malignant renal epithelium by AN HANG YANG, OBERLEY, T. D, OBERLEY, L. W, SCHMID, S. M, CUMMINGS, K. B

“…The activities of three antioxidant enzymes, superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated human renal adenocarcinoma…”
Get full text

In vitro Modulation of Antioxid Ant Enzymes in Normal and Malignant Renal Epithelium by An Hang Yang, Oberley, Terry D., Oberley, Larry W., Steven M. Schmid, Cummings, Kenneth B.

“…The activities of three antioxidant enzymes, Superoxide dismutase, catalase, and glutathione peroxidase, were monitored in isolated human renal adenocarcinoma…”
Get full text

Evaluation of combinations of interferons and cytotoxic drugs in murine tumor models in vivo by Harrison, Jr, S D, Stevens, J J, Waud, W R, Dykes, D J, Schmid, S M, Griswold, Jr, D P

“…This investigation was conducted to provide preclinical in vivo tumor response data collected under standardized conditions with a range of clinically useful…”
Get more information