Search Results - "Schmid, Ralf S."

Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins by Stockwell, Brent R, Hoffstrom, Benjamin G, Kaplan, Anna, Letso, Reka, Schmid, Ralf S, Turmel, Gregory J, Lo, Donald C

“…Expression of a Huntington's-disease variant of huntingtin protein causes accumulation of the chaperone protein disulfide isomerase. This protein is the target…”
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Reactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model by Okolie, Onyinyechukwu, Bago, Juli R, Schmid, Ralf S, Irvin, David M, Bash, Ryan E, Miller, C Ryan, Hingtgen, Shawn D

“…Surgical resection is a universal component of glioma therapy. Little is known about the postoperative microenvironment due to limited preclinical models…”
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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B by Tahtouh, Tania, Elkins, Jonathan M, Filippakopoulos, Panagis, Soundararajan, Meera, Burgy, Guillaume, Durieu, Emilie, Cochet, Claude, Schmid, Ralf S, Lo, Donald C, Delhommel, Florent, Oberholzer, Anselm E, Pearl, Laurence H, Carreaux, François, Bazureau, Jean-Pierre, Knapp, Stefan, Meijer, Laurent

“…DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer’s…”
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Tumor-homing cytotoxic human induced neural stem cells for cancer therapy by Bagó, Juli R, Okolie, Onyi, Dumitru, Raluca, Ewend, Matthew G, Parker, Joel S, Werff, Ryan Vander, Underhill, T Michael, Schmid, Ralf S, Miller, C Ryan, Hingtgen, Shawn D

“…Engineered neural stem cells (NSCs) are a promising approach to treating glioblastoma (GBM). The ideal NSC drug carrier for clinical use should be easily…”
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Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life by Jiménez, Jessica A, Ptacek, Travis S, Tuttle, Alex H, Schmid, Ralf S, Moy, Sheryl S, Simon, Jeremy M, Zylka, Mark J

“…Chromodomain helicase DNA-binding protein 8 (Chd8) is a high-confidence risk gene for autism spectrum disorder (ASD). However, how Chd8 haploinsufficiency…”
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PIK3CA missense mutations promote glioblastoma pathogenesis, but do not enhance targeted PI3K inhibition by McNeill, Robert S, Stroobant, Emily E, Smithberger, Erin, Canoutas, Demitra A, Butler, Madison K, Shelton, Abigail K, Patel, Shrey D, Limas, Juanita C, Skinner, Kasey R, Bash, Ryan E, Schmid, Ralf S, Miller, C Ryan

“…Glioblastoma (GBM) is the most common adult primary brain tumor. Multimodal treatment is empiric and prognosis remains poor. Recurrent PIK3CA missense…”
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Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease by Braithwaite, Steven P, Schmid, Ralf S, He, Dong Ning, Sung, Mei-Li A, Cho, Seongeon, Resnick, Lynn, Monaghan, Michael M, Hirst, Warren D, Essrich, Christian, Reinhart, Peter H, Lo, Donald C

“…Abstract The c-Jun N-terminal kinase (JNK) pathway potentially links together the three major pathological hallmarks of Alzheimer's disease (AD): development…”
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Genomic profiles of low-grade murine gliomas evolve during progression to glioblastoma by Vitucci, Mark, Irvin, David M, McNeill, Robert S, Schmid, Ralf S, Simon, Jeremy M, Dhruv, Harshil D, Siegel, Marni B, Werneke, Andrea M, Bash, Ryan E, Kim, Seungchan, Berens, Michael E, Miller, C Ryan

“…Gliomas are diverse neoplasms with multiple molecular subtypes. How tumor-initiating mutations relate to molecular subtypes as these tumors evolve during…”
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Correction to: Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life by Jiménez, Jessica A, Ptacek, Travis S, Tuttle, Alex H, Schmid, Ralf S, Moy, Sheryl S, Simon, Jeremy M, Zylka, Mark J

“…An amendment to this paper has been published and can be accessed via the original article…”
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Neuregulin 1-erbB2 Signaling Is Required for the Establishment of Radial Glia and Their Transformation into Astrocytes in Cerebral Cortex by Schmid, Ralf S., McGrath, Barbara, Berechid, Bridget E., Boyles, Becky, Marchionni, Mark, Šestan, Nenad, Anton, Eva S.

“…Radial glial cells and astrocytes function to support the construction and maintenance, respectively, of the cerebral cortex. However, the mechanisms that…”
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Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex by Ghashghaei, H T, Weimer, Jill M, Schmid, Ralf S, Yokota, Yukako, McCarthy, Ken D, Popko, Brian, Anton, E S

“…Radial glial cells play a critical role in the construction of mammalian brain by functioning as a source of new neurons and by providing a scaffold for radial…”
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CRISPR/Cas9 directed to the Ube3a antisense transcript improves Angelman syndrome phenotype in mice by Schmid, Ralf S, Deng, Xuefeng, Panikker, Priyalakshmi, Msackyi, Msema, Breton, Camilo, Wilson, James M

“…Gene editing holds the potential to correct mutations and cure devastating genetic disorders. The technology has not yet proven efficacious for therapeutic use…”
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Reelin, Integrin and Dab1 Interactions during Embryonic Cerebral Cortical Development by Schmid, Ralf S., Jo, Rebecca, Shelton, Stephanie, Kreidberg, Jordan A., Anton, E. S.

“…Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as α3β1 integrin can regulate neuronal migration and position in the…”
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L1 and NCAM adhesion molecules as signaling coreceptors in neuronal migration and process outgrowth by Schmid, Ralf S, Maness, Patricia F

“…Neural cell adhesion molecules (CAMs) of the immunoglobulin superfamily engage in multiple neuronal interactions that influence cell migration, axonal and…”
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Generation and characterization of brain lipid-binding protein promoter-based transgenic mouse models for the study of radial glia by Schmid, Ralf S., Yokota, Yukako, Anton, E. S.

“…Radial glia play an essential role in the generation of the cerebral cortex through their function as neuronal precursors and as neuronal migration guides. A…”
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Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma by McNeill, Robert S, Canoutas, Demitra A, Stuhlmiller, Timothy J, Dhruv, Harshil D, Irvin, David M, Bash, Ryan E, Angus, Steven P, Herring, Laura E, Simon, Jeremy M, Skinner, Kasey R, Limas, Juanita C, Chen, Xin, Schmid, Ralf S, Siegel, Marni B, Van Swearingen, Amanda E D, Hadler, Michael J, Sulman, Erik P, Sarkaria, Jann N, Anders, Carey K, Graves, Lee M, Berens, Michael E, Johnson, Gary L, Miller, C Ryan

“…Glioblastoma (GBM) is the most common and aggressive primary brain tumor. Prognosis remains poor despite multimodal therapy. Developing alternative treatments…”
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Core pathway mutations induce de-differentiation of murine astrocytes into glioblastoma stem cells that are sensitive to radiation but resistant to temozolomide by Schmid, Ralf S, Simon, Jeremy M, Vitucci, Mark, McNeill, Robert S, Bash, Ryan E, Werneke, Andrea M, Huey, Lauren, White, Kristen K, Ewend, Matthew G, Wu, Jing, Miller, C Ryan

“…Glioma stem cells (GSCs) from human glioblastomas (GBMs) are resistant to radiation and chemotherapy and may drive recurrence. Treatment efficacy may depend on…”
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Genetically engineered mouse models of diffuse gliomas by Schmid, Ralf S, Vitucci, Mark, Miller, C. Ryan

“…Highlights ► Mouse models define the genetic basis for glioma initiation and progression. ► Mouse models can be used to identify the cells from which gliomas…”
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Cooperativity between MAPK and PI3K signaling activation is required for glioblastoma pathogenesis by Vitucci, Mark, Karpinich, Natalie O, Bash, Ryan E, Werneke, Andrea M, Schmid, Ralf S, White, Kristen K, McNeill, Robert S, Huff, Byron, Wang, Sophie, Van Dyke, Terry, Miller, C Ryan

“…Glioblastoma (GBM) genomes feature recurrent genetic alterations that dysregulate core intracellular signaling pathways, including the G1/S cell cycle…”
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A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome by SCHMID, Ralf S, TSUJIMOTO, Naomi, QIANG QU, HONG LEI, EN LI, TAIPING CHEN, SPIELEWOY BLAUSTEIN, Cecile

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