Search Results - "Schmid, Herbert A"

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues by Biron, Eric, Chatterjee, Jayanta, Ovadia, Oded, Langenegger, Daniel, Brueggen, Joseph, Hoyer, Daniel, Schmid, Herbert A, Jelinek, Raz, Gilon, Chaim, Hoffman, Amnon, Kessler, Horst

“…Full methyl jacket? A complete library of the N‐methylated somatostatin cyclopeptidic analogue Veber–Hirschmann peptide cyclo(‐PFwKTF‐) has been prepared with…”
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Effects of somatostatin analogs on glucose homeostasis in rats by Schmid, Herbert A, Brueggen, Josef

“…Pasireotide (SOM230) is a multireceptor-targeted somatostatin analog with high binding affinity for sstr1,2,3 and sstr5. The effects of pasireotide and…”
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Opportunities in somatostatin research: biological, chemical and therapeutic aspects by Weckbecker, Gisbert, Lewis, Ian, Albert, Rainer, Schmid, Herbert A, Hoyer, Daniel, Bruns, Christian

“…Somatostatins -- also known as somatotropin-release inhibiting factors (SRIFs) -- are a family of cyclopeptides that have broad inhibitory effects on the…”
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Lung volume quantified by MRI reflects extracellular-matrix deposition and altered pulmonary function in bleomycin models of fibrosis: effects of SOM230 by Egger, Christine, Gérard, Christelle, Vidotto, Nella, Accart, Nathalie, Cannet, Catherine, Dunbar, Andrew, Tigani, Bruno, Piaia, Alessandro, Jarai, Gabor, Jarman, Elizabeth, Schmid, Herbert A, Beckmann, Nicolau

“…Idiopathic pulmonary fibrosis is a progressive and lethal disease, characterized by loss of lung elasticity and alveolar surface area, secondary to alveolar…”
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Somatostatin receptor activation is involved in the control of daily torpor in a seasonal mammal by Scherbarth, Frank, Diedrich, Victoria, Dumbell, Rebecca A, Schmid, Herbert A, Steinlechner, Stephan, Barrett, Perry

“…Siberian hamsters (Phodopus sungorus) show spontaneous daily torpor only after ∼2 mo in winter-like short photoperiods (SP). Although some SP-induced hormonal…”
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Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors by Schmid, Herbert A, Schoeffter, Philippe

“…Functional gastroenteropancreatic tumors express all 5 somatostatin receptor subtypes (sst) in different quantities. Octreotide and lanreotide treat patients…”
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Somatostatin receptors in non-neuroendocrine malignancies: the potential role of somatostatin analogs in solid tumors by Hasskarl, Jens, Kaufmann, Martina, Schmid, Herbert A

“…Somatostatin receptors (sstrs) are G-protein-coupled receptors that mediate various physiological effects when activated by the neuropeptide somatostatin or…”
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Pasireotide (SOM230) is effective for the treatment of pancreatic neuroendocrine tumors (PNETs) in a multiple endocrine neoplasia type 1 (MEN1) conditional knockout mouse model by Quinn, Thomas J., BS, Yuan, Ziqiang, MD, Adem, Asha, BS, Geha, Rula, MD, Vrikshajanani, Chakravarthy, MD, Koba, Wade, BS, Fine, Eugene, MD, Hughes, David T., MD, Schmid, Herbert A., PhD, Libutti, Steven K., MD

“…Background Pasireotide (SOM230), a long-acting somatostatin analogue (LAR), has improved agonist activity at somatostatin receptors. We tested the effect of…”
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Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion by Zatelli, Maria Chiara, Piccin, Daniela, Vignali, Cristina, Tagliati, Federico, Ambrosio, Maria Rosaria, Bondanelli, Marta, Cimino, Vincenzo, Bianchi, Antonio, Schmid, Herbert A, Scanarini, Massimo, Pontecorvi, Alfredo, De Marinis, Laura, Maira, Giulio, Uberti, Ettore C degli

“…Somatostatin (SRIF) analogs have been employed in medical therapy of non-functioning pituitary adenomas (NFA), with contrasting results. Previous evidence…”
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The Somatostatin Analog SOM230 (Pasireotide) Ameliorates Injury of the Intestinal Mucosa and Increases Survival after Total-Body Irradiation by Inhibiting Exocrine Pancreatic Secretion by Fu, Qiang, Berbée, Maaike, Boerma, Marjan, Wang, Junru, Schmid, Herbert A., Hauer-Jensen, Martin

“…Fu, Q., Berbée, M., Boerma, M., Wang, J., Schmid, H. A. and Hauer-Jensen, M. The Somatostatin Analog SOM230 (Pasireotide) Ameliorates Injury of the Intestinal…”
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Monoclonal antibodies against the human somatostatin receptor subtypes 1-5: development and immunohistochemical application in neuroendocrine tumors by Schmid, Herbert A, Lambertini, Chiara, van Vugt, Harmke H, Barzaghi-Rinaudo, Patrizia, Schäfer, Judith, Hillenbrand, Rainer, Sailer, Andreas W, Kaufmann, Martina, Nuciforo, Paolo

“…Activation of somatostatin receptors (sstr1-5) by somatostatin and its analogues exerts an inhibitory effect on hormone secretion and provides the basis for…”
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Preclinical Evaluation of SOM230 as a Radiation Mitigator in a Mouse Model: Postexposure Time Window and Mechanisms of Action by Fu, Qiang, Berbée, Maaike, Wang, Wenze, Boerma, Marjan, Wang, Junru, Schmid, Herbert A., Hauer-Jensen, Martin

“…The somatostatin analog SOM230 has potent radioprophylactic and radiation mitigating properties that are unrelated to cytoprotection but appear to be due to…”
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Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus by Riediger, Thomas, Traebert, Martin, Schmid, Herbert A, Scheel, Caroline, Lutz, Thomas A, Scharrer, Erwin

“…The recently discovered hormone ghrelin, which is secreted from the stomach during fasting and hypoglycemia opposes the homeostatic functions of leptin by…”
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Differential Effects of Octreotide and Pasireotide on Somatostatin Receptor Internalization and Trafficking in Vitro by Lesche, Sarah, Lehmann, Diana, Nagel, Falko, Schmid, Herbert A., Schulz, Stefan

“…Objective: The clinically used somatostatin analogs, octreotide and lanreotide, act primarily by binding to somatostatin receptor 2 (sst2). In contrast, the…”
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Amylin potently activates AP neurons possibly via formation of the excitatory second messenger cGMP by Riediger, T, Schmid, H A, Lutz, T, Simon, E

“…Amylin is secreted with insulin from the pancreas during and after food intake. One of the most potent actions of amylin in vivo is its anorectic effect, which…”
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Regulation of ghrelin secretion by somatostatin analogs in rats by Silva, Antonio P, Bethmann, Kerstin, Raulf, Friedrich, Schmid, Herbert A

“…Objective: Ghrelin is a hormone present in the plasma in two forms: octanoylated and des-octanoylated ghrelin. In pathophysiological conditions such as…”
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Pasireotide (SOM230): Development, mechanism of action and potential applications by Schmid, Herbert A.

“…Pasireotide (SOM230) is a multi-receptor ligand somatostatin analogue with high binding affinity for somatostatin receptor subtypes sst 1,2,3 and sst 5…”
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SOM230, A New Somatostatin Analogue, Is Highly Effective in the Therapy of Growth Hormone/Prolactin-Secreting Pituitary Adenomas by FEDELE, Monica, DE MARTINO, Ivana, HOFLAND, Leo, LOMBARDI, Gaetano, COLAO, Annamaria, FUSCO, Alfredo, PIVONELLO, Rosario, CIARMIELLO, Andrea, DEL BASSO DE CARO, M. Laura, VISONE, Rosa, PALMIERI, Dario, PIERANTONI, Giovanna M, ARRA, Claudio, SCHMID, Herbert A

“…Purpose: We have previously shown that transgenic mice ubiquitously overexpressing the HMGA2 gene develop growth hormone/prolactin-secreting pituitary…”
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SOM230: a new therapeutic modality for Cushing's disease by Lewis, Ian, Schmid, Herbert A, Kneuer, Rainer, Hoyer, Daniel, Silva, Antonio P, Weckbecker, Gisbert, Bruns, Christian, Pless, Janos

“…A rational drug design approach involving transposition of functional groups from SRIF into a reduced size cyclohexapeptide template has led to the discovery…”
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Ectopic expression of Pax4 in pancreatic δ cells results in β-like cell neogenesis by Druelle, Noémie, Vieira, Andhira, Shabro, Aidin, Courtney, Monica, Mondin, Magali, Rekima, Samah, Napolitano, Tiziana, Silvano, Serena, Navarro-Sanz, Sergi, Hadzic, Biljana, Avolio, Fabio, Rassoulzadegan, Minoo, Schmid, Herbert A, Mansouri, Ahmed, Collombat, Patrick

“…The recent demonstration that pancreatic α cells can be continuously regenerated and converted into β-like cells upon ectopic expression of opened new avenues…”
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