Search Results - "Schmetzer, H M"

Quantification of ex vivo generated dendritic cells (DC) and leukemia-derived DC contributes to estimate the quality of DC, to detect optimal DC-generating methods or to optimize DC-mediated T-cell-activation-procedures ex vivo or in vivo by SCHMETZER, H. M, KREMSER, A, LOIBL, J, KROELL, T, KOLB, H-J

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Serum-free generation and quantification of functionally active leukemia-derived DC is possible from malignant blasts in acute myeloid leukemia and myelodysplastic syndromes by KUFNER, S, FLEISCHER, R. Pelka, KROELL, T, SCHMID, C, ZITZELSBERGER, H, SALIH, H, DE VALLE, F, TREDER, W, SCHMETZER, H. M

“…Functional dendritic cells (DC) are professional antigen presenting cells (APC) and can be generated in vitro from leukemic cells from acute myeloid leukemia…”
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Conversion of AML-blasts to leukemia-derived dendritic cells (DCleu) in ‘DC-culture-media’ shifts correlations of released chemokines with antileukemic T-cell reactions by Merle, M., Fischbacher, D., Liepert, A., Grabrucker, C., Kroell, T., Kremser, A., Dreyssig, J., Freudenreich, M., Schuster, F., Borkhardt, A., Kraemer, D., Koehne, C.-H., Kolb, H.J., Schmid, C., Schmetzer, H.M.

“…Dendritic cells (DC) and T-cells are mediators of CTL-responses. Autologous (from patients with acute myeloid leukaemia (AML) or myelodysplasia (MDS)) or…”
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Serum Chemokine-release Profiles in AML-patients Might Contribute to Predict the Clinical Course of the Disease by Merle, M., Fischbacher, D., Liepert, A., Grabrucker, C., Kroell, T., Kremser, A., Dreyssig, J., Freudenreich, M., Schuster, F., Borkhardt, A., Kraemer, D., Koehne, C.-H., Kolb, H. J., Schmid, C., Schmetzer, H. M.

“…In cancer or hematologic disorders, chemokines act as growth- or survival factors, regulating hematopoiesis and angiogenesis, determining metastatic spread and…”
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Soluble CD137 (4-1BB) Ligand Is Released Following Leukocyte Activation and Is Found in Sera of Patients with Hematological Malignancies by Salih, Helmut R, Schmetzer, Helga M, Burke, Christine, Starling, Gary C, Dunn, Robert, Pelka-Fleischer, Renate, Nuessler, Volkmar, Kiener, Peter A

“…Expression of CD137 ligand (4-1BBL), a member of the TNF family of proteins, has been reported on several types of APCs, various carcinoma cells, and can be…”
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Leukemia‐Derived Dendritic Cells can be Generated from Blood or Bone Marrow Cells from Patients with Acute Myeloid Leukaemia: A Methodological Approach under Serum‐Free Culture Conditions by Kufner, S., Zitzelsberger, H., Kroell, T., Pelka‐Fleischer, R., Salem, A., De Valle, F., Schweiger, C., Nuessler, V., Schmid, C., Kolb, H. J., Schmetzer, H. M.

“…Functional dendritic cells (DC) are professional antigen‐presenting cells (APC) and can be generated in vitro from healthy as well as from leukaemic cells from…”
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P04.01 Volatile profiling using an eNose allows differentiation of volatile phases derived from serum, DC, or MLC culture supernatants from healthy or leukemic samples by Baudrexler, T, Boeselt, T, Bohlscheid, S, Li, L, Schmid, C, Rank, A, Schmohl, J, Schmetzer, HM

“…BackgroundVolatile organic compounds (VOCs) reflect the metabolism in healthy and pathological conditions. They can be collected easily in a noninvasive…”
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Minor Histocompatibility Antigen UTY as Target for Graft‐versus‐Leukemia and Graft‐versus‐Haematopoiesis in the Canine Model by Bund, D., Buhmann, R., Gökmen, F., Zorn, J., Kolb, H.‐J., Schmetzer, H. M.

“…Male patients with female‐stem‐cell donors have better prognosis compared to female‐to‐male combinations due to Y‐encoded minor histocompatibility antigens…”
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P07.02 Control leukemia by inducing anti-cancer immune reactivity in vivo? – Potential of a DC-triggered mechanism by Schmetzer, HM, Amberger, D, Klauer, L, Rackl, E, Atzler, M, Ugur, S, Plett, C, Rabe, A, Kugler, C, Rank, A, Baudrexler, T, Inngjerdingen, M, Eiz-Vesper, B, Schmid, C

“…BackgroundKit-M, the combination of response-modifiers GM-CSF+ Prostaglandine (PGE)1, converts myeloid blasts into dendritic cells(DC) of leukemic origin…”
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High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis by Steiner, K, Graf, M, Hecht, K, Reif, S, Rossbacher, L, Pfister, K, Kolb, H-J, Schmetzer, H M, Multhoff, G

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Leukaemia‐Derived Dendritic Cells Can Be Generated From Blood or Bone Marrow Cells From Patients With Myelodysplasia: A Methodological Approach Under Serum‐Free Culture Conditions by Kufner, S., Zitzelsberger, H., Kroell, T., Pelka‐Fleischer, R., Salem, A., De Valle, F., Schmid, C., Schweiger, C., Kolb, H. J., Schmetzer, H. M.

“…Functional dendritic cells (DC) are professional antigen‐presenting cells (APC) and can be generated in vitro from healthy as well as from leukaemic cells from…”
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Cytogenetic and Southern blot analysis to demonstrate clonality and to estimate prognosis in patients with myelodysplastic syndromes by SCHMETZER, H. M, POLECK, B, DUELL, T, GERHARTZ, H. H, MITTERMÜLLER, J

“…We examined the bone marrow of 109 patients with myelodysplastic syndrome (MDS) at the time of diagnosis and during the course of the disease by means of…”
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GM-CSF stimulates proliferation of clonal leukemic bone marrow cells in acute myeloid leukemia (AML) in vitro by SCHMETZER, H. M, GERHARTZ, H. H, WILMANNS, W

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) is known to stimulate granulocytes, monocytes, and macrophages. We studied the effect of GM-CSF on…”
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Cytokines can reduce clonal, CD34-positive cells in acute myeloid leukemia in vitro by BRAUN, S, GERHARTZ, H. H, SCHMETZER, H. M

“…We studied the influence of cytokine mixes on the survival of acute myeloid leukemia (AML) bone-marrow (BM) cells in a 14-day culture assay in vitro…”
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Clonality analysis as a tool to study the biology and response to therapy in myelodysplastic syndromes by SCHMETZER, H. M, POLECK, B, MITTERMÜLLER, J, DUELL, T, WILMANNS, W, GERHARTZ, H. H

“…We examined the bone marrow of 45 patients with MDS at the time of diagnosis and in the course of the disease by means of Southern blot analysis and…”
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Immunological classification of chronic myeloid leukemia distinguishes chronic phase, imminent blastic transformation, and acute lymphoblastic leukemia by Schmetzer, H M, Gerhartz, H H

“…The clinical course of chronic myeloid leukemia (CML) is highly variable and therefore it is difficult to predict the duration of the chronic phase. We studied…”
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Serum levels of sCD137 (4-1BB) ligand are prognostic factors for progression in acute myeloid leukemia but not in non-Hodgkin's lymphoma by Hentschel, N., Krusch, M., Kiener, P. A., Kolb, H. J., Salih, H. R., Schmetzer, H. M.

“…:  CD178 (Fas/APO‐1 ligand) and CD137 ligand (CD137L) have previously been described in sera of patients with various malignancies and play an important role…”
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Gene rearrangements in bone marrow cells of patients with acute myelogenous leukemia by Schmetzer, H M, Braun, S, Wiesner, D, Duell, T, Gerhartz, H H, Mittermueller, J

“…At diagnosis, clonal gene rearrangement probes [retinoic acid receptor (RAR)-alpha, major breakpoint cluster region (M-bcr), immunoglobulin (Ig)-JH, T cell…”
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Acute myeloid leukemia (AML) can be oligoclonal by Schmetzer, H M, Gerhartz, H H

“…Acute myeloid leukemia (AML) is usually thought to represent a monoclonal disease. Among 45 cases of newly diagnosed AML we found rearranged bands in 14 cases…”
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Detection of acute myeloid leukemic cells in complete remission and in extramedullary sites by clonal analyses by Schmetzer, H M, Wilmanns, W, Gerhartz, H H

“…We report the case of a 49-year-old woman with acute myeloid leukemia (AML, M5b). The leukemic cells expressed blast as well as myelomonocytic antigens and…”
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