Search Results - "Schmeichel, Brooke"

Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-administration and Stress-Induced Reinstatement in Rats by Schmeichel, Brooke E, Herman, Melissa A, Roberto, Marisa, Koob, George F

“…Abstract Background Cocaine addiction is characterized by patterns of compulsive drug-taking, including preoccupation with obtaining cocaine and loss of…”
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Noradrenergic modulation of wakefulness/arousal by Berridge, Craig W, Schmeichel, Brooke E, España, Rodrigo A

“…Summary The locus coeruleus-noradrenergic system supplies norepinephrine throughout the central nervous system. State-dependent neuronal discharge activity of…”
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Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors by Somkuwar, Sucharita S, Vendruscolo, Leandro F, Fannon, McKenzie J, Schmeichel, Brooke, Nguyen, Tran Bao, Guevara, Jasmin, Sidhu, Harpreet, Contet, Candice, Zorrilla, Eric P, Mandyam, Chitra D

“…Highlights • Chronic ethanol enhances peak CORT and does not alter nadir CORT. • Acute withdrawal from chronic ethanol enhances irritability-like behavior. •…”
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Norepinephrine at the nexus of arousal, motivation and relapse by España, Rodrigo A, Schmeichel, Brooke E, Berridge, Craig W

“…Abstract Arousal plays a critical role in cognitive, affective and motivational processes. Consistent with this, the dysregulation of arousal-related neural…”
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Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats by Schmeichel, Brooke E, Matzeu, Alessandra, Koebel, Pascale, Vendruscolo, Leandro F, Sidhu, Harpreet, Shahryari, Roxana, Kieffer, Brigitte L, Koob, George F, Martin-Fardon, Rémi, Contet, Candice

“…The hypocretin/orexin (HCRT) neuropeptide system regulates feeding, arousal state, stress responses, and reward, especially under conditions of enhanced…”
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Neurocircuitry Underlying the Preferential Sensitivity of Prefrontal Catecholamines to Low-Dose Psychostimulants by SCHMEICHEL, Brooke E, BERRIDGE, Craig W

“…Low doses of psychostimulants, including methylphenidate (MPH), are highly effective in the treatment of attention-deficit/hyperactivity disorder (ADHD). At…”
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Kappa Opioid Receptor-Mediated Dysregulation of Gamma-Aminobutyric Acidergic Transmission in the Central Amygdala in Cocaine Addiction by Kallupi, Marsida, Wee, Sunmee, Edwards, Scott, Whitfield, Timothy W, Oleata, Christopher S, Luu, George, Schmeichel, Brooke E, Koob, George F, Roberto, Marisa

“…Background Studies have demonstrated an enhanced dynorphin/kappa-opioid receptor (KOR) system following repeated cocaine exposure, but few reports have focused…”
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Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats by Schmeichel, Brooke E, Barbier, Estelle, Misra, Kaushik K, Contet, Candice, Schlosburg, Joel E, Grigoriadis, Dimitri, Williams, John P, Karlsson, Camilla, Pitcairn, Caleb, Heilig, Markus, Koob, George F, Vendruscolo, Leandro F

“…The hypocretin/orexin (HCRT) system has been associated with both positive and negative drug reinforcement, implicating HCRT receptor 1 (HCRT-R1) signaling in…”
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Effects of Alcohol Withdrawal on Sleep Macroarchitecture and Microarchitecture in Female and Male Rats by Jones, Marissa R., Brandner, Adam J., Vendruscolo, Leandro F., Vendruscolo, Janaina C. M., Koob, George F., Schmeichel, Brooke E.

“…The prevalence of sleep disruptions is higher among people with alcohol use disorder (AUD), particularly during alcohol withdrawal, compared to non-AUD…”
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A selective dopamine reuptake inhibitor improves prefrontal cortex-dependent cognitive function: Potential relevance to attention deficit hyperactivity disorder by Schmeichel, Brooke E., Zemlan, Frank P., Berridge, Craig W.

“…Drugs used to treat attention deficit hyperactivity disorder (ADHD) improve prefrontal cortex (PFC)-dependent cognitive function. The majority of ADHD-related…”
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Compulsive-Like Sufentanil Vapor Self-Administration in Rats by Vendruscolo, Janaina C M, Tunstall, Brendan J, Carmack, Stephanie A, Schmeichel, Brooke E, Lowery-Gionta, Emily G, Cole, Maury, George, Olivier, Vandewater, Sophia A, Taffe, Michael A, Koob, George F, Vendruscolo, Leandro F

“…Opioid misuse is at historically high levels in the United States, with inhalation (ie, smoking and vaping) being one of the most common routes of consumption…”
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Hypocretin /orexin preferentially activates caudomedial ventral tegmental area dopamine neurons by Vittoz, Nicole M., Schmeichel, Brooke, Berridge, Craig W.

“…The hypocretin/orexin (HCRT) neuropeptide system modulates behavioral state and state‐dependent processes via actions on multiple neuromodulatory transmitter…”
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Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats by Tunstall, Brendan J., Ho, Chelsea P., Cao, Jianjing, Vendruscolo, Janaína C.M., Schmeichel, Brooke E., Slack, Rachel D., Tanda, Gianluigi, Gadiano, Alexandra J., Rais, Rana, Slusher, Barbara S., Koob, George F., Newman, Amy H., Vendruscolo, Leandro F.

“…Methamphetamine (METH) is a highly addictive drug, but no pharmacological treatment is yet available for METH use disorders. Similar to METH, the…”
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Wake-promoting actions of noradrenergic α1- and β-receptors within the lateral hypothalamic area by Schmeichel, Brooke E., Berridge, Craig W.

“…Central norepinephrine exerts potent wake‐promoting effects, in part through the actions of noradrenergic α1‐ and β‐receptors located in the medial septal and…”
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Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats by Aldridge, Gabriel M., Zarin, Tyler A., Brandner, Adam J., George, Olivier, Gilpin, Nicholas W., Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Koob, George F., Vendruscolo, Leandro F., Schmeichel, Brooke E.

“…Hypocretin/orexin (HCRT) is a neuropeptide that is associated with both stress and reward systems in humans and rodents. The different contributions of…”
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Amphetamine acts within the lateral hypothalamic area to elicit affectively neutral arousal and reinstate drug-seeking by Schmeichel, Brooke E., Berridge, Craig W.

“…Psychostimulants, including amphetamine (AMPH), exert robust arousal-enhancing, reinforcing and locomotor-activating effects. These behavioural actions involve…”
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Wake‐promoting actions of noradrenergic α 1 ‐ and β‐receptors within the lateral hypothalamic area by Schmeichel, Brooke E., Berridge, Craig W.

“…Abstract Central norepinephrine exerts potent wake‐promoting effects, in part through the actions of noradrenergic α 1 ‐ and β‐receptors located in the medial…”
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M152 - Transgenerational Effects of Parental Fentanyl Dependence on Sleep and Cognition During Adolescence by Jones, Marissa, Schmeichel, Brooke

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Transgenerational Effects of Parental Fentanyl Dependence on Sleep and Cognition During Adolescence by Jones, Marissa, Schmeichel, Brooke

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Addiction as a stress surfeit disorder by Koob, George F., Buck, Cara L., Cohen, Ami, Edwards, Scott, Park, Paula E., Schlosburg, Joel E., Schmeichel, Brooke, Vendruscolo, Leandro F., Wade, Carrie L., Whitfield, Timothy W., George, Olivier

“…Drug addiction has been conceptualized as a chronically relapsing disorder of compulsive drug seeking and taking that progresses through three stages:…”
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