Search Results - "Schmehl, T."

Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG–PEI by Kleemann, E., Neu, M., Jekel, N., Fink, L., Schmehl, T., Gessler, T., Seeger, W., Kissel, T.

“…Gene therapy aimed at the respiratory epithelium holds therapeutic potential for diseases such as cystic fibrosis and lung cancer. Polyethylenimine (PEI) has…”
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Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension by Reichenberger, F, Voswinckel, R, Enke, B, Rutsch, M, El Fechtali, E, Schmehl, T, Olschewski, H, Schermuly, R, Weissmann, N, Ghofrani, H. A, Grimminger, F, Mayer, E, Seeger, W

“…For chronic thromboembolic pulmonary hypertension not amenable to pulmonary endarterectomy, effective medical therapy is desired. In an open-label uncontrolled…”
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Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung by Dailey, L.A., Jekel, N., Fink, L., Gessler, T., Schmehl, T., Wittmar, M., Kissel, T., Seeger, W.

“…Particulate nanocarriers have been praised for their advantageous drug delivery properties in the lung, such as avoidance of macrophage clearance mechanisms…”
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Surfactant-free, biodegradable nanoparticles for aerosol therapy based on the branched polyesters, DEAPA-PVAL-g-PLGA by DAILEY, L. A, KLEEMANN, E, WITTMAR, M, GESSLER, T, SCHMEHL, T, ROBERTS, C, SEEGER, W, KISSEL, T

“…This study describes the development of surfactant-free, biodegradable nanoparticle systems with varying physicochemical properties and their suitability for…”
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Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and haemodynamics by Walmrath, D, Grimminger, F, Pappert, D, Knothe, C, Obertacke, U, Benzing, A, Gunther, A, Schmehl, T, Leuchte, H, Seeger, W

“…The aim of the present study was to investigate the feasibility and efficacy of bronchoscopic surfactant administration in a noncontrolled multicentre study in…”
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Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties by Gunther, A, Schmidt, R, Harodt, J, Schmehl, T, Walmrath, D, Ruppert, C, Grimminger, F, Seeger, W

“…The purpose of the present study was to investigate the impact of bronchoscopic surfactant administration, on the biochemical and biophysical surfactant…”
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Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: investigations of the complex structure and stability during air-jet and ultrasonic nebulization by Kleemann, E., Dailey, L.A., Abdelhady, H.G., Gessler, T., Schmehl, T., Roberts, C.J., Davies, M.C., Seeger, W., Kissel, T.

“…Polyelectrolyte complexes between DNA and polyethylenimine (PEI) are promising non-viral delivery systems for pulmonary inhalation gene therapy and thus…”
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Pulmonary absorption of aerosolized fluorescent markers in the isolated rabbit lung by Lahnstein, Kerstin, Schmehl, Thomas, Rüsch, Ute, Rieger, Monika, Seeger, Werner, Gessler, Tobias

“…For the development of aerosolized controlled release formulations such as liposomes or nanoparticles, the use of suitable model drugs is necessary. This study…”
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Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension by Gessler, T, Schmehl, T, Hoeper, M.M, Rose, F, Ghofrani, H.A, Olschewski, H, Grimminger, F, Seeger, W

“…Inhalation of iloprost, a stable prostacyclin analogue, is a promising perspective in the treatment of pulmonary hypertension. In initial clinical studies, a…”
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Modified polyethylenimines as non viral gene delivery systems for aerosol therapy: effects of nebulization on cellular uptake and transfection efficiency by Dailey, L.A., Kleemann, E., Merdan, T., Petersen, H., Schmehl, T., Gessler, T., Hänze, J., Seeger, W., Kissel, T.

“…This study examined the effect of nebulization on the cellular uptake and transfection efficiency of polyplexes from four polyethylenimine (PEI) modifications:…”
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Ultrasonic nebulization for efficient delivery of surfactant in a model of acute lung injury : Impact on gas exchange by SCHERMULY, R, SCHMEHL, T, GÜNTHER, A, GRIMMINGER, F, SEEGER, W, WALMRATH, D

“…We investigated the effect of ultrasonic nebulization versus instillation of exogenous surfactant on gas exchange abnormalities provoked by detergent…”
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On-line laser-photometric monitoring of aerosol deposition in ventilated rabbit lungs by Schmehl, T, Gebhart, J, Schütte, H, Scharmann, A, Seeger, W

“…A photometric technique was developed for on-line measurement of aerosol deposition in isolated, ventilated, and perfused rabbit lungs. A jet nebulizer was…”
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Correlation of drug release with pulmonary drug absorption profiles for nebulizable liposomal formulations by Beck-Broichsitter, Moritz, Rieger, Monika, Reul, Regina, Gessler, Tobias, Seeger, Werner, Schmehl, Thomas

“…5(6)-Carboxyfluorescein (CF)-loaded submicron liposomal formulations with varying phase transition display adjustable in vitro drug release properties with…”
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Inhaled prostanoids in the therapy of pulmonary hypertension by Gessler, Tobias, Seeger, Werner, Schmehl, Thomas

“…Prostacyclin and prostacyclin analogues are potent vasodilators and possess antithrombotic, anti-inflammatory and antiproliferative properties. These…”
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Pulmonary targeting with biodegradable salbutamol-loaded nanoparticles by Beck-Broichsitter, Moritz, Gauss, Julia, Gessler, Tobias, Seeger, Werner, Kissel, Thomas, Schmehl, Thomas

“…Aerosol therapy using particulate drug carriers has become an increasingly attractive method to deliver therapeutic or diagnostic compounds to the lung…”
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Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features by Dailey, Lea Ann, Schmehl, Thomas, Gessler, Tobias, Wittmar, Matthias, Grimminger, Friedrich, Seeger, Werner, Kissel, Thomas

“…Nanoparticles may be effective drug delivery systems for use in various pulmonary therapeutic schemes. This study investigated the effect of nebulization…”
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Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension by Olschewski, Horst, Rohde, Beate, Behr, Jürgen, Ewert, Ralph, Gessler, Tobias, Ghofrani, H Ardeschir, Schmehl, Thomas

“…Inhalation of iloprost, a stable prostacyclin analog, is an effective therapy for pulmonary hypertension with few side effects. This approach may, however, be…”
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Dry powder nebulization of a recombinant surfactant protein C-based surfactant for treatment of acute respiratory distress syndrome by Ruppert, C, Kuchenbuch, T, Schmidt, S, Markart, P, Gessler, T, Schmehl, T, Seeger, W, Guenther, A

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Inhaled iloprost To treat severe pulmonary hypertension : An uncontrolled trial by OLSCHEWSKI, H, GHOFRANI, H. A, SCHMEHL, T, WINKLER, J, WILKENS, H, HÖPER, M. M, BEHR, J, KLEBER, F.-X, SEEGER, W

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Alveolar epithelial barrier functions in ventilated perfused rabbit lungs by Ghofrani, H A, Kohstall, M G, Weissmann, N, Schmehl, T, Schermuly, R T, Seeger, W, Grimminger, F

“…We employed ultrasonic nebulization for homogeneous alveolar tracer deposition into ventilated perfused rabbit lungs. (22)Na and (125)I-albumin transit…”
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