Search Results - "Schmees, C"

Key role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells by Kaistha, B P, Honstein, T, Müller, V, Bielak, S, Sauer, M, Kreider, R, Fassan, M, Scarpa, A, Schmees, C, Volkmer, H, Gress, T M, Buchholz, M

“…Background: Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive human malignancies with an overall 5-year survival rate of <5%. Despite…”
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Compound efficacy testing using a microplate co-culture assay comprising patient derived 3D tumor spheroids and autologous immune cells by Bodenhöfer, M, Anderle, N, Hennenlotter, J, Stenzl, A, Schmees, C

“…An abstract of a study by Bodenhofer et al assessing compound efficacy testing using a microplate co-culture assay comprising patient derived 3D tumor…”
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Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V by Schmees, C, Villaseñor, R, Zheng, W, Ma, H, Zerial, M, Heldin, C-H, Hellberg, C

“…Receptor tyrosine kinase (RTK) signaling is frequently increased in tumor cells, sometimes as a result of decreased receptor down-regulation. The extent to…”
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Impact of intratumoral heterogeneity of renal cancer on drug response and development of resistance in patient derived xenografts by Zeisig, R, Flechsig, S, Wulf-Goldenberg, A, Schmees, C, Jandrig, B, Hennenlotter, J, Bedke, J, Stenzl, A, Schostak, M, Becker, M, Fichtner, I, Hoffmann, J

“…Background: Patients with advanced renal cell carcinoma (RCC) have a poor prognosis due to fast onset of resistance towards Standard of Care (SoC) drugs…”
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Inhibition of autophagy as a therapeutic concept in renal cell carcinoma by Stuehler, V., Rausch, S., Winter, S., Schmees, C., Stenzl, A., Bedke, J., Schwab, M., Schaeffeler, E.

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Project PRIMO – Combining Patient Derived Breast Cancer Microtumors and DigiWest protein signaling pathway profiling for therapeutic response prediction by Anderle, N., Ruoff, F., Koch, A., Hartkopf, A., Brucker, S., Templin, M., Schmees, C.

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Autophagy as a new therapeutic pathway by Stuehler, V., Rausch, S., Winter, S., Schmees, C., Maas, M., Walz, S., Stenzl, A., Bedke, J., Schwab, M., Schaeffeler, E.

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A microplate co-culture assay allows individualised compound efficacy testing in patients derived 3D tumour spheroids and autologous immune cells by Bedke, J, Bodenhöfer, M, Harland, N, Hennenlotter, J, Anderle, N, Schmees, C, Stenzl, A

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Prostate cancer genomics: Identification of prognostic markers from the bone marrow by Bier, S, Hennenlotter, J, Haerle, U, Karpatsi, E, Stenzl, A, Todenhoefer, T, Schmees, C

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153 - Compound efficacy testing using a microplate co-culture assay comprising patient derived 3D tumor spheroids and autologous immune cells by Bodenhöfer, M., Anderle, N., Hennenlotter, J., Stenzl, A., Schmees, C.

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Establishment and characterization of a preclinical platform of subcutaneous renal cell carcinoma (RCC) patient-derived xenograft models to evaluate novel treatment strategies by Kobelt, D., Gürgen, D., Becker, M., Dahlmann, M., Flechsig, S., Schaeffeler, E., Büttner, F.A., Schmees, C., Bohnert, R., Bedke, J., Schwab, M., Wendler, J.J., Schostak, M., Jandrig, B., Walther, W., Hofmann, J.

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P10.25.A ATR INHIBITION IN EXPERIMENTAL GLIOMA: DISCOVERY AND VALIDATION OF MOLECULAR TARGETS FOR FUNCTIONALLY-INSTRUCTED COMBINATION THERAPIES by Walter, B, Hirsch, S, Kuhlburger, L, Stahl, A, Schnabel, L, Haeusser, L A, Tsiami, F, Ploeger, S, Aghaallaei, N, Dick, A M, Skokowa, J, Schmees, C, Templin, M, Schenke-Layland, K, Tatagiba, M, Nahnsen, S, Merk, D, Tabatabai, G

“…Abstract BACKGROUND The DNA damage response (DDR) is an important physiological network for the prevention of malignant transformation, e.g. by halting the…”
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TCR engaging antigen-scaffolds for targeted expansion of functionally improved T cells for adoptive cell therapy by Kladis, G., Mindahl, V. Rafa, Tamhane, T., Bentzen, A. Kai, Donia, M., Svane, I.M., Niessner, H., Sinnberg, T., Garbe, C., Jacobsen, S. Nyboe, Schmees, C., Hadrup, S. Reker

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Impact of intratumoral heterogeneity of renal cancer on drug response and development of resistance in patient derived xenografts by Bedke, J, Flechsig, S, Hennenlotter, J, Wulf-Goldenberg, A, Jandrig, A, Schostak, M, Becker, M, Fichtner, I, Zeisig, R, Hoffmann, J, Schmees, C, Stenzl, A

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171P Immune-modulatory drug profiling using perfused, microfluidic on-chip co-cultures of patient-derived ovarian cancer microtumors and autologous immune cells by Plöger, S., Wegner, E., Schmidt, T., Roosz, J., Anderle, N., Maulana, T.I., Christ, L., Koch, A., Brucker, S., Schenke-Layland, K., Loskill, P., Schmees, C.

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212 - Impact of intratumoral heterogeneity of renal cancer on drug response and development of resistance in patient derived xenografts by Zeisig, R., Flechsig, S., Wulf-Goldenberg, A., Schmees, C., Jandrig, B., Hennenlotter, J., Bedke, J., Stenzl, A., Schostak, M., Becker, M., Fichtner, I., Hoffmann, J.

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Alterations of the nailfold capillary morphology associated with Raynaud phenomenon in patients with systemic lupus erythematosus by Caspary, L, Schmees, C, Schoetensack, I, Hartung, K, Stannat, S, Deicher, H, Creutzig, A, Alexander, K

“…Quantitative analysis of nailfold capillary morphology was performed in age and sex matched groups of 29 patients with systemic lupus erythematosus (SLE)…”
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A Secreted Low--Molecular-Weight Protein From Helicobacter pylori Induces Cell-Cycle Arrest of T Cells by Gerhard, Markus, Schmees, Christian, Voland, Petra, Endres, Nicole, Sander, Markus, Reindl, Wolfgang, Rad, Roland, Oelsner, Madlene, Decker, Thomas, Mempel, Martin, Hengst, Ludger, Prinz, Christian

“…Background & aims: Although Helicobacter pylori is recognized by the human immune system, the bacteria are not eliminated and lead to a chronic inflammation of…”
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45 - A preclinical model to assess the interaction between patient-derived 3D microtumors and tumor infiltrating immune cells in prostate cancer by Erne, E., Stahl, R., Bodenhoefer, M., Anderle, N., Yuez, S., Stenzl, A., Schmees, C., Todenhoefer, T.

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A preclinical model to assess the interaction between patient-derived 3D microtumors and tumor infiltrating immune cells in prostate cancer by Erne, E., Stahl, R., Bodenhoefer, M., Anderle, N., Yuez, S., Stenzl, A., Schmees, C., Todenhoefer, T.

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