Search Results - "Schmeckpeper, Jeffrey"

Paracrine mechanisms of stem cell reparative and regenerative actions in the heart by Mirotsou, Maria, Jayawardena, Tilanthi M, Schmeckpeper, Jeffrey, Gnecchi, Massimiliano, Dzau, Victor J

“…Abstract Stem cells play an important role in restoring cardiac function in the damaged heart. In order to mediate repair, stem cells need to replace injured…”
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C3orf58, a Novel Paracrine Protein, Stimulates Cardiomyocyte Cell-Cycle Progression Through the PI3K–AKT–CDK7 Pathway by Beigi, Farideh, Schmeckpeper, Jeffrey, Pow-anpongkul, Pete, Payne, James Alan, Zhang, Lunan, Zhang, Zhiping, Huang, Jing, Mirotsou, Maria, Dzau, Victor J

“…RATIONALE:The regenerative capacity of the heart is markedly diminished shortly after birth, coinciding with overall withdrawal of cardiomyocytes from cell…”
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Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1 by Hynes, Brian, Kumar, Arun H S, O'Sullivan, John, Klein Buneker, Chirlei, Leblond, Anne-Laure, Weiss, Sharon, Schmeckpeper, Jeffrey, Martin, Kenneth, Caplice, Noel M

“…We have previously reported the cardioprotective effects of endothelial progenitor cell (EPC)-conditioned media (CM) therapy post-myocardial infarction (MI)…”
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Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2 by Rodriguez Garcia, Michelle, Schmeckpeper, Jeffrey, Landim-Vieira, Maicon, Coscarella, Isabella Leite, Fang, Xuan, Ma, Weikang, Spran, Payton A, Yuan, Shengyao, Qi, Lin, Kahmini, Aida Rahimi, Shoemaker, M. Benjamin, Atkinson, James B, Kekenes-Huskey, Peter M, Irving, Thomas C, Chase, Prescott Bryant, Knollmann, Björn C, Pinto, Jose Renato

“…The ACTN2 gene encodes α-actinin 2, located in the Z-disc of the sarcomeres in striated muscle. In this study, we sought to investigate the effects of an ACTN2…”
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Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways by Schmeckpeper, Jeffrey, Verma, Amanda, Yin, Lucy, Beigi, Farideh, Zhang, Lunan, Payne, Alan, Zhang, Zhiping, Pratt, Richard E, Dzau, Victor J, Mirotsou, Maria

“…Abstract Wnt signaling has recently emerged as an important regulator of cardiac progenitor cell proliferation and differentiation, but the exact mechanisms by…”
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Infected Cell Carriers: A New Strategy for Systemic Delivery of Oncolytic Measles Viruses in Cancer Virotherapy by Iankov, Ianko D, Blechacz, Boris, Liu, Chunsheng, Schmeckpeper, Jeffrey D, Tarara, James E, Federspiel, Mark J, Caplice, Noel, Russell, Stephen J

“…Attenuated measles viruses (MVs) propagate selectively in human tumor cells, and phase I clinical trials are currently underway to test their oncolytic…”
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Thrombin Stimulates Smooth Muscle Cell Differentiation From Peripheral Blood Mononuclear Cells via Protease-Activated Receptor-1, RhoA, and Myocardin by Martin, Kenneth, Weiss, Sharon, Metharom, Pat, Schmeckpeper, Jeffrey, Hynes, Brian, O’Sullivan, John, Caplice, Noel

“…RATIONALE:Smooth muscle precursor cells have previously been reported to reside in bone marrow and in the circulation, but little is currently known regarding…”
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Comparison of clinical symptoms and bioimpedance to pulmonary capillary wedge pressure in heart failure by Polcz, Monica, Huston, Jessica, Breed, Meghan, Case, Marisa, Leisy, Philip, Schmeckpeper, Jeffrey, Vaughn, Lexie, Sobey, Jenna Helmer, Brophy, Colleen, Lindenfeld, JoAnn, Hocking, Kyle, Alvis, Bret

“…Clinical symptoms of heart failure commonly include fatigue, edema, and shortness of breath. Unfortunately, clinical monitoring has proven unreliable in…”
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Respiratory Non-Invasive Venous Waveform Analysis for Assessment of Respiratory Distress in Coronavirus Disease 2019 Patients: An Observational Study by Alvis, Bret, Vaughn, Lexie, Schmeckpeper, Jeffrey, Huston, Jessica, Case, Marisa, Semler, Matthew, Lindenfeld, JoAnn, Brophy, Colleen, Hocking, Kyle

“…OBJECTIVES: Due to the rapid rate of severe acute respiratory syndrome coronavirus 2 transmission and the heterogeneity of symptoms of coronavirus disease…”
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Animal Models to Study Cardiac Arrhythmias by Blackwell, Daniel J., Schmeckpeper, Jeffrey, Knollmann, Bjorn C.

“…Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting for 10% to 15% of all deaths. Although most arrhythmias are due to…”
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Adult Renal Mesenchymal Stem Cell―Like Cells Contribute to Juxtaglomerular Cell Recruitment by HAO WANG, GOMEZ, Jose A, PRATT, Richard E, SAUR, Dieter, MIROTSOU, Maria, DZAU, Victor J, KLEIN, Sabine, ZHIPING ZHANG, SEIDLER, Barbara, YANQIANG YANG, SCHMECKPEPER, Jeffrey, LUNAN ZHANG, MURAMOTO, Garrett G, CHUTE, John

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RIGHT HEART, NO RESPECT: THE IMPORTANCE OF EARLY RECOGNITION OF RIGHT VENTRICULAR FAILURE by Gupta, Richa, Schmeckpeper, Jeffrey, Haddad, Elias

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B-PO01-017 RYR2 HYPERACTIVITY PROMOTES SUSCEPTIBILITY TO VENTRICULAR TACHYCARDIA IN STRUCTURAL HEART DISEASE by Kim, Kyungsoo, Schmeckpeper, Jeffrey, Blackwell, Daniel J., Knollmann, Bjorn C.

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Abstract 13939: Triiodothyronine and Dexamethasone Enhances Electrophysiological Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Wang, Lili, Wada, Yuko, Ballan, Nimer, Schmeckpeper, Jeffrey, Gepstein, Lior, Knollmann, Bjorn C

“…BackgroundHuman induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) technology opens new avenues for disease modeling and drug development. However,…”
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Abstract 11402: Targeting RyR2 to Suppress Ventricular Arrhythmias and Improve Left Ventricular Function in Chronic Ischemic Heart Disease by Schmeckpeper, Jeffrey, Kim, Kyungsoo, Blackwell, Daniel J, Woodall, Kaylen, Knollmann, Bjorn C

“…IntroductionSarcoplasmic reticulum Ca+2 leak from RyR2 is a common finding in chronic ischemic heart disease (CIHD) and may be a key driver for ventricular…”
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Triiodothyronine and dexamethasone alter potassium channel expression and promote electrophysiological maturation of human-induced pluripotent stem cell-derived cardiomyocytes by Wang, Lili, Wada, Yuko, Ballan, Nimer, Schmeckpeper, Jeffrey, Huang, Jijun, Rau, Christoph Daniel, Wang, Yibin, Gepstein, Lior, Knollmann, Bjorn C.

“…Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have emerged as a promising tool for disease modeling and drug development. However,…”
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RECURRENT, CULTURE-NEGATIVE ENDOCARDITIS: DON't GET WHIPPED by Patel, Jay, Clark, Dan, Gupta, Richa, Davogustto, Giovanni, Schmeckpeper, Jeffrey, Baker, Michael

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RyR2 inhibition with dantrolene is antiarrhythmic, prevents further pathological remodeling, and improves cardiac function in chronic ischemic heart disease by Schmeckpeper, Jeffrey, Kim, Kyungsoo, George, Sharon A., Blackwell, Daniel J., Brennan, Jaclyn A., Efimov, Igor R., Knollmann, Bjorn C.

“…Diastolic Ca2+ leak due to cardiac ryanodine receptor (RyR2) hyperactivity has been widely documented in chronic ischemic heart disease (CIHD) and may…”
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Non-invasive Venous Waveform Analysis (niva) Correlates With Pulmonary Capillary Wedge Pressure And Predicts 30-day Admission In Heart Failure Patients Undergoing Right Heart Catheterization by Alvis, Bret D., Huston, Jessica, Schmeckpeper, Jeffrey, Polcz, Monica, Case, Marisa, Breed, Meghan, Vaughn, Lexie, Hocking, Kyle, Lindenfeld, JoAnn

“…Heart failure is the leading cause of hospitalization in the elderly and readmission is common. Clinical parameters of congestion are of limited value and…”
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Role of cardiac alpha-actinin 2 pathogenic variant in human myocardium mechanics by Rodriguez Garcia, Michelle C., Landim-Vieira, Maicon, Schmeckpeper, Jeffrey, Wang, Lili, Shoemaker, Moore B., Chase, Prescott B., Knollmann, Bjorn C., Pinto, J. Renato

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