Search Results - "Schmöle, Anne‐Caroline"

CB2 Receptor in Microglia: The Guardian of Self-Control by Komorowska-Müller, Joanna Agnieszka, Schmöle, Anne-Caroline

“…Microglia are key to maintaining the homeostasis of the brain. These immune cells of the brain can be our biggest ally in fighting infections, but can worsen…”
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Cannabinoid receptor 2 is necessary to induce toll‐like receptor‐mediated microglial activation by Reusch, Nico, Ravichandran, Kishore Aravind, Olabiyi, Bolanle Fatimat, Komorowska‐Müller, Joanna Agnieszka, Hansen, Jan N., Ulas, Thomas, Beyer, Marc, Zimmer, Andreas, Schmöle, Anne‐Caroline

“…The tight regulation of microglia activity is key for precise responses to potential threats, while uncontrolled and exacerbated microglial activity is…”
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CB2 receptor deletion on myeloid cells enhanced mechanical allodynia in a mouse model of neuropathic pain by Nent, Elisa, Nozaki, Chihiro, Schmöle, Anne-Caroline, Otte, David, Zimmer, Andreas

“…Neuropathic pain can develop after nerve injury, leading to a chronic condition with spontaneous pain and hyperalgesia. Pain is typically restricted to the…”
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Cannabinoid Receptor 2-Deficiency Ameliorates Disease Symptoms in a Mouse Model with Alzheimer's Disease-Like Pathology by Schmöle, Anne-Caroline, Lundt, Ramona, Toporowski, Gregor, Hansen, Jan N, Beins, Eva, Halle, Annett, Zimmer, Andreas

“…It is widely accepted that the endocannabinoid system (ECS) is a modulator of neuroinflammation associated with neurodegenerative disorders, including…”
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Cannabinoid Receptor 2 Alters Social Memory and Microglial Activity in an Age-Dependent Manner by Komorowska-Müller, Joanna Agnieszka, Rana, Tanushka, Olabiyi, Bolanle Fatimat, Zimmer, Andreas, Schmöle, Anne-Caroline

“…Physiological brain aging is characterized by gradual, substantial changes in cognitive ability, accompanied by chronic activation of the neural immune system…”
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Expression Analysis of CB2-GFP BAC Transgenic Mice by Schmöle, Anne-Caroline, Lundt, Ramona, Gennequin, Benjamin, Schrage, Hanna, Beins, Eva, Krämer, Alexandra, Zimmer, Till, Limmer, Andreas, Zimmer, Andreas, Otte, David-Marian

“…The endocannabinoid system (ECS) is a retrograde messenger system, consisting of lipid signaling molecules that bind to at least two G-protein-coupled…”
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Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells by Lange, Christian, Mix, Eilhard, Frahm, Jana, Glass, Änne, Müller, Jana, Schmitt, Oliver, Schmöle, Anne-Caroline, Klemm, Kristin, Ortinau, Stefanie, Hübner, Rayk, Frech, Moritz J., Wree, Andreas, Rolfs, Arndt

“…▶ Differential ability of GSK-3 inhibitors to decrease enzymatic activity of GSK-3. ▶ SB-216763 and kenpaullone interfere with GSK-3 mediated signaling. ▶…”
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Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model by Schmöle, Anne-Caroline, Lundt, Ramona, Ternes, Svenja, Albayram, Önder, Ulas, Thomas, Schultze, Joachim L, Bano, Daniele, Nicotera, Pierluigi, Alferink, Judith, Zimmer, Andreas

“…Abstract Several studies have indicated that the cannabinoid receptor 2 (CB2) plays an important role in neuroinflammation associated with Alzheimer's disease…”
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Impact of the endocannabinoid system on murine cranial and alveolar bone phenotype by Setiawan, Maria, Jäger, Andreas, Daratsianos, Nikolaos, Reimann, Susanne, Chen, Junliang, Schmöle, Anne-Caroline, Derichs-Schönthal, Daniel, Konermann, Anna

“…The endocannabionoid signaling system has been demonstrated to be present in the skeleton, with involvement in the regulation of skeletal homeostasis. However,…”
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Differentiation of human neural progenitor cells regulated by Wnt-3a by Hübner, Rayk, Schmöle, Anne-Caroline, Liedmann, Andrea, Frech, Moritz J., Rolfs, Arndt, Luo, Jiankai

“…► Wnt-3a and β-catenin induce TCF-mediated transcription in ReNcell VM cells. ► Wnt-3a and β-catenin increase Wnt target genes Axin2, LEF1 and CyclinD1. ►…”
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Novel indolylmaleimide acts as GSK-3β inhibitor in human neural progenitor cells by Schmöle, Anne-Caroline, Brennführer, Anne, Karapetyan, Gnuni, Jaster, Robert, Pews-Davtyan, Anahit, Hübner, Rayk, Ortinau, Stefanie, Beller, Matthias, Rolfs, Arndt, Frech, Moritz J.

“…IM-12 enhances canonical Wnt signalling in human neural progenitor cells, for example, shown by a peri-nuclear accumulation of β-catenin demonstrated by…”
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Correction: Expression Analysis of CB2-GFP BAC Transgenic Mice by Schmöle, Anne-Caroline, Lundt, Ramona, Gennequin, Benjamin, Schrage, Hanna, Beins, Eva, Krämer, Alexandra, Zimmer, Till, Limmer, Andreas, Zimmer, Andreas, Otte, David-Marian

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Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells by Eisenlöffel, Christian, Schmöle, Anne-Caroline, Pews-Davtyan, Anahit, Brennführer, Anne, Kuznetsov, Sergei A., Hübner, Rayk, Frech, Stefanie, Schult, Catrin, Junghanss, Christian, Beller, Matthias, Rolfs, Arndt, Frech, Moritz J.

“…PDA-66 hinders proliferation of human progenitor and cancer cells by destabilising microtubules, leading to mitotic arrest and apoptosis. Thus…”
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Small molecules in stem cell research by Schmöle, Anne-Caroline, Hübner, Rayk, Beller, Matthias, Rolfs, Arndt, Frech, Moritz J

“…Stem cells possess great promise as therapeutic tools for neurological disorders such as neurodegenerative diseases (Parkinson's disease and Huntington's…”
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A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3beta inhibitors by Pews-Davtyan, Anahit, Tillack, Annegret, Schmöle, Anne-Caroline, Ortinau, Stefanie, Frech, Moritz J, Rolfs, Arndt, Beller, Matthias

“…3-Amidoindoles were synthesized from commercially available arylhydrazines and propargylamines over Zn-salt mediated one pot procedure in excellent…”
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Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells by Schmöle, Anne-Caroline, Brennführer, Anne, Karapetyan, Gnuni, Jaster, Robert, Pews-Davtyan, Anahit, Hübner, Rayk, Ortinau, Stefanie, Beller, Matthias, Rolfs, Arndt, Frech, Moritz J

“…The Wnt pathway is involved in cellular processes linked to either proliferation or differentiation. Therefore small molecules offer an attractive opportunity…”
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Expression Analysis of CB2-GFP BAC Transgenic Mice: e0138986 by Schmole, Anne-Caroline, Lundt, Ramona, Gennequin, Benjamin, Schrage, Hanna, Beins, Eva, Kraemer, Alexandra, Zimmer, Till, Limmer, Andreas, Zimmer, Andreas, Otte, David-Marian

“…The endocannabinoid system (ECS) is a retrograde messenger system, consisting of lipid signaling molecules that bind to at least two G-protein-coupled…”
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