Search Results - "Schlifke, Irene"

Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy by Kanter-Schlifke, Irene, Georgievska, Biljana, Kirik, Deniz, Kokaia, Merab

“…Temporal lobe epilepsy patients remain refractory to available anti-epileptic drugs in 30% of cases, indicating a need for novel therapeutic strategies. In…”
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Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures by Woldbye, David P. D., Ängehagen, Mikael, Gøtzsche, Casper R., Elbrønd-Bek, Heidi, Sørensen, Andreas T., Christiansen, Søren H., Olesen, Mikkel V., Nikitidou, Litsa, Hansen, Thomas v. O., Kanter-Schlifke, Irene, Kokaia, Merab

“…Gene therapy using recombinant adeno-associated viral vectors overexpressing neuropeptide Y in the hippocampus exerts seizure-suppressant effects in rodent…”
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VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures by Nikitidou, Litsa, Kanter-Schlifke, Irene, Dhondt, Joke, Carmeliet, Peter, Lambrechts, Diether, Kokaia, Mérab

“…Vascular endothelial growth factor (VEGF) was first described as an angiogenic agent, but has recently also been shown to exert various neurotrophic and…”
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NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning by Sørensen, Andreas T., Kanter-Schlifke, Irene, Carli, Mirjana, Balducci, Claudia, Noe, Francesco, During, Matthew J., Vezzani, Annamaria, Kokaia, Merab

“…Recombinant adeno‐associated viral (rAAV) vector‐induced neuropeptide Y (NPY) overexpression in the hippocampus exerts powerful antiepileptic and…”
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Hippocampal NPY gene transfer attenuates seizures without affecting epilepsy-induced impairment of LTP by Sørensen, Andreas T., Nikitidou, Litsa, Ledri, Marco, Lin, En-Ju D., During, Matthew J., Kanter-Schlifke, Irene, Kokaia, Merab

“…Recently, hippocampal neuropeptide Y ( NPY) gene therapy has been shown to effectively suppress both acute and chronic seizures in animal model of epilepsy,…”
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GDNF released from encapsulated cells suppresses seizure activity in the epileptic hippocampus by Kanter-Schlifke, Irene, Fjord-Larsen, Lone, Kusk, Philip, Ängehagen, Mikael, Wahlberg, Lars, Kokaia, Merab

“…To date, a variety of pharmacological treatments exists for patients suffering epilepsy, but systemically administered drugs offer only symptomatic relief and…”
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Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat by Kanter-Schlifke, Irene, Georgievska, Biljana, Kirik, Deniz, Kokaia, Merab

“…We investigated the feasibility of viral vector-mediated expression and axonal transport of the glial cell-line-derived neurotrophic factor, a potential…”
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Making the patient voice heard in a research consortium: experiences from an EU project (IMI-APPROACH) by Taylor, Jane, Dekker, Sjouke, Jurg, Diny, Skandsen, Jon, Grossman, Maureen, Marijnissen, Anne-Karien, Ladel, Christoph, Mobasheri, Ali, Larkin, Jon, Weinans, Harrie, Kanter-Schlifke, Irene

“…APPROACH is an EU-wide research consortium with the goal to identify different subgroups of knee osteoarthritis to enable future differential diagnosis and…”
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Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum by Sørensen, Andreas T., Kanter-Schlifke, Irene, Lin, En-Ju D., During, Matthew J., Kokaia, Merab

“…Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being…”
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Correction to: Making the patient voice heard in a research consortium: experiences from an EU project (IMI-APPROACH) by Taylor, Jane, Dekker, Sjouke, Jurg, Diny, Skandsen, Jon, Grossman, Maureen, Marijnissen, Anne-Karien, Ladel, Christoph, Mobasheri, Ali, Larkin, Jon, Weinans, Harrie, Kanter-Schlifke, Irene

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Remote monitoring technologies in Alzheimer's disease: design of the RADAR-AD study by Muurling, Marijn, de Boer, Casper, Kozak, Rouba, Religa, Dorota, Koychev, Ivan, Verheij, Herman, Nies, Vera J M, Duyndam, Alexander, Sood, Meemansa, Fröhlich, Holger, Hannesdottir, Kristin, Erdemli, Gul, Lucivero, Federica, Lancaster, Claire, Hinds, Chris, Stravopoulos, Thanos G, Nikolopoulos, Spiros, Kompatsiaris, Ioannis, Manyakov, Nikolay V, Owens, Andrew P, Narayan, Vaibhav A, Aarsland, Dag, Visser, Pieter Jelle

“…Functional decline in Alzheimer's disease (AD) is typically measured using single-time point subjective rating scales, which rely on direct observation or…”
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Editorial by Gurny, Robert, Kanter-Schlifke, Irene

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Upregulation of cytokine mRNA in circulating leukocytes during human endotoxemia by Jilma-Stohlawetz, Petra, Kliegel, Tuende, Kantner-Schlifke, Irene, Strasser-Marsik, Claudia, Mayr, Florian B, Jilma, Bernd

“…Endotoxemia induces pronounced changes in leukocyte count and enhances the release of many cytokines. However, the molecular regulation of this cytokine…”
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VEGF Receptor-2 by Nikitidou, Litsa, Kanter-Schlifke, Irene, Dhondt, Joke, Carmeliet, Peter, Lambrechts, Diether, Kokaia, Mérab

“…Vascular endothelial growth factor (VEGF) was first described as an angiogenic agent, but has recently also been shown to exert various neurotrophic and…”
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Effect of interleukin-6 blockade on tissue factor-induced coagulation in human endotoxemia by Derhaschnig, Ulla, Bergmair, Doris, Marsik, Claudia, Schlifke, Irene, Wijdenes, John, Jilma, Bernd

“…OBJECTIVE:Clinical trials show that interleukin (IL)-6 represents a predictive marker in human sepsis. Furthermore, IL-6 has been proposed as a candidate…”
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Galanin expressed in the excitatory fibers attenuates synaptic strength and generalized seizures in the piriform cortex of mice by Schlifke, Irene, Kuteeva, Eugenia, Hokfelt, Tomas, Kokaia, Merab

“…The neuropeptide galanin is considered to be an endogenous antiepileptic agent, presumably acting via inhibition of glutamate release. Previously, we have…”
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Galanin gene transfer curtails generalized seizures in kindled rats without altering hippocampal synaptic plasticity by Kanter-Schlifke, I, Toft Sørensen, A, Ledri, M, Kuteeva, E, Hökfelt, T, Kokaia, M

“…Abstract Gene therapy–based overexpression of endogenous seizure-suppressing molecules represents a promising treatment strategy for epilepsy. Viral…”
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VASCULAR ENDOTHELIAL GROWTH FACTOR SUPPRESSES EPILEPTIC ACTIVITY IN MICE by Nikitidou, Litsa, Kanter Schlifke, Irene, Kokaia, Merab

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Endotoxemia enhances expression of the signaling receptor (GP130) on protein and molecular level by Marsik, Claudia, Halama, Thomas, Cardona, Francesco, Schlifke, Irene, Mittermayer, Friedrich, Jilma, Bernd

“…Interleukin 6 (IL-6) performs a prominent role during sepsis. To examine the molecular regulation of IL-6, IL-6 receptor, and signaling receptor gp130 during…”
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