Search Results - "Schliffke, Simon"

Immunophenotyping of Newly Diagnosed and Recurrent Glioblastoma Defines Distinct Immune Exhaustion Profiles in Peripheral and Tumor-infiltrating Lymphocytes by Mohme, Malte, Schliffke, Simon, Maire, Cecile L, Rünger, Alessandra, Glau, Laura, Mende, Klaus C, Matschke, Jakob, Gehbauer, Christina, Akyüz, Nuray, Zapf, Svenja, Holz, Mareike, Schaper, Miriam, Martens, Tobias, Schmidt, Nils O, Peine, Sven, Westphal, Manfred, Binder, Mascha, Tolosa, Eva, Lamszus, Katrin

“…Immunotherapeutic treatment strategies for glioblastoma (GBM) are under investigation in clinical trials. However, our understanding of the immune phenotype of…”
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SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2 by von Wenserski, Lisa, Schultheiß, Christoph, Bolz, Sarah, Schliffke, Simon, Simnica, Donjete, Willscher, Edith, Gerull, Helwe, Wolters-Eisfeld, Gerrit, Riecken, Kristoffer, Fehse, Boris, Altfeld, Marcus, Nollau, Peter, Binder, Mascha

“…We identified a subset of Chronic Lymphocytic Leukemia (CLL) patients with high Signaling Lymphocytic Activation Molecule Family (SLAMF) receptor-related…”
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Local Intracerebral Immunomodulation Using Interleukin-Expressing Mesenchymal Stem Cells in Glioblastoma by Mohme, Malte, Maire, Cecile L, Geumann, Ulf, Schliffke, Simon, Dührsen, Lasse, Fita, Krystian, Akyüz, Nuray, Binder, Mascha, Westphal, Manfred, Guenther, Christine, Lamszus, Katrin, Hermann, Felix G, Schmidt, Nils Ole

“…Mesenchymal stem cells (MSCs) show an inherent brain tumor tropism that can be exploited for targeted delivery of therapeutic genes to invasive glioma. We…”
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Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells by Ren, Yongming, Lee, Min Young, Schliffke, Simon, Paavola, Jere, Amos, Peter J, Ge, Xin, Ye, Mingyu, Zhu, Shenjun, Senyei, Grant, Lum, Lawrence, Ehrlich, Barbara E, Qyang, Yibing

“…Abstract Human induced pluripotent stem (iPS) cells potentially provide a unique resource for generating patient-specific cardiomyocytes to study cardiac…”
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T cell receptor next-generation sequencing reveals cancer-associated repertoire metrics and reconstitution after chemotherapy in patients with hematological and solid tumors by Simnica, Donjete, Akyüz, Nuray, Schliffke, Simon, Mohme, Malte, v.Wenserski, Lisa, Mährle, Thorben, Fanchi, Lorenzo F., Lamszus, Katrin, Binder, Mascha

“…The dynamics of immunoaging and the onset of immunoparesis in healthy individuals and cancer patients has been controversially discussed. Moreover, the role of…”
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Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy by Paavola, Jere, Schliffke, Simon, Rossetti, Sandro, Kuo, Ivana Y.-T, Yuan, Shiaulou, Sun, Zhaoxia, Harris, Peter C, Torres, Vicente E, Ehrlich, Barbara E

“…Abstract Mutations in PKD1 and PKD2 , the genes encoding the proteins polycystin-1 (PC1) and polycystin-2 (PC2), cause autosomal dominant polycystic kidney…”
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High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias by Simnica, Donjete, Schliffke, Simon, Schultheiß, Christoph, Bonzanni, Nicola, Fanchi, Lorenzo F, Akyüz, Nuray, Gösch, Barbara, Casar, Christian, Thiele, Benjamin, Schlüter, Janina, Lohse, Ansgar W, Binder, Mascha

“…Autoimmune cytopenias (AIC) such as immune thrombocytopenia or autoimmune hemolytic anemia are claimed to be essentially driven by a dysregulated immune…”
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Molecular profiling of an osseous metastasis in glioblastoma during checkpoint inhibition: potential mechanisms of immune escape by Mohme, Malte, Maire, Cecile L, Schliffke, Simon, Joosse, Simon A, Alawi, Malik, Matschke, Jakob, Schüller, Ulrich, Dierlamm, Judith, Martens, Tobias, Pantel, Klaus, Riethdorf, Sabine, Lamszus, Katrin, Westphal, Manfred

“…Peripheral metastases of glioblastoma (GBM) are very rare despite the ability of GBM cells to pass through the blood-brain barrier and be disseminated through…”
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Fatal Myelotoxicity Following Palliative Chemotherapy With Cisplatin and Gemcitabine in a Patient With Stage IV Cholangiocarcinoma Linked to Post Mortem Diagnosis of Fanconi Anemia by Engel, Nils W, Schliffke, Simon, Schüller, Ulrich, Frenzel, Christian, Bokemeyer, Carsten, Kubisch, Christian, Lessel, Davor

“…Unrecognized genome instability syndromes can potentially impede the rational treatment of cancer in rare patients. Identification of cancer patients with a…”
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Dynamic changes of the normal B lymphocyte repertoire in CLL in response to ibrutinib or FCR chemo-immunotherapy by Schliffke, Simon, Sivina, Mariela, Kim, Ekaterina, von Wenserski, Lisa, Thiele, Benjamin, Akyüz, Nuray, Falker-Gieske, Clemens, Statovci, Donjete, Oberle, Anna, Thenhausen, Toni, Krohn-Grimberghe, Artus, Bokemeyer, Carsten, Jain, Nitin, Estrov, Zeev, Ferrajoli, Alessandra, Wierda, William, Keating, Michael, Burger, Jan A., Binder, Mascha

“…Using next-generation immunoglobulin (IGH) sequencing and flow cytometry, we characterized the composition, diversity and dynamics of non-malignant B cells in…”
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T-cell repertoire profiling by next-generation sequencing reveals tissue migration dynamics of TRBV13-family clonotypes in a common experimental autoimmune encephalomyelitis mouse model by Schliffke, Simon, Carambia, Antonella, Akyüz, Nuray, Thiele, Benjamin, Herkel, Johannes, Binder, Mascha

“…The experimental autoimmune encephalomyelitis (EAE) model is indispensable for autoimmunity research, but model-specific T cell dynamics are sparsely studied…”
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Ibrutinib-associated focal segmental glomerulosclerosis and the impact of podocin mutations in chronic lymphocytic leukemia by Czogalla, Jan, Schliffke, Simon, Lu, Shun, Schwerk, Maria, Petereit, Helena, Zhang, Tianran, Liu, Shuya, Dumoulin, Bernhard, Gies, Sydney, Wu, Guochao, Hänzelmann, Sonja, Bode, Marlies, Grahammer, Florian, Gödel, Markus, Voigtländer, Minna, Butt, Linus, Bokemeyer, Carsten, Bergmann, Carsten, Benzing, Thomas, Wiech, Thorsten, Puelles, Victor G, Huber, Tobias B

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RARE-26. WHOLE GENOME SEQUENCING OF AN OSSEOUS METASTASIS DURING CHECKPOINT-CONTROLLED INTRACRANIAL GLIOBLASTOMA REVEALS NEW INSIGHTS INTO POTENTIAL MECHANISMS OF IMMUNE ESCAPE by Mohme, Malte, Maire, Cecile, Schliffke, Simon, Joosse, Simon, Alawi, Malik, Lamszus, Katrin, Westphal, Manfred

“…Abstract Glioblastoma (GBM) has a devastating prognosis and recent advances in the treatment of a variety of cancer entities, e.g. through checkpoint…”
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The phosphotyrosine phosphatase SHP2 promotes anergy in chronic lymphocytic leukemia by Schliffke, Simon, Buhs, Sophia, Bolz, Sarah, Gerull, Helwe, von Wenserski, Lisa, Riecken, Kristoffer, Fehse, Boris, Nollau, Peter, Binder, Mascha

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High-Dose Chemotherapy and Autologous Stem Cell Transplant in Elderly and Fit Primary CNS Lymphoma Patients - a Multicenter Study By the Cooperative PCNSL Study Group (MARTA study) by Schorb, Elisabeth, Isbell, Lisa, Kerkhoff, Andrea, Mathas, Stephan, Braulke, Friederike, Egerer, Gerlinde, Roeth, Alexander, Schliffke, Simon Christian, Borchmann, Peter, Brunnberg, Uta, Kroschinsky, Frank P., Möhle, Robert, Rank, Andreas, Wellnitz, Dominique, Kasenda, Benjamin, Pospiech, Lisa, Wendler, Julia, Ihorst, Gabriele, Scherer, Florian, Deckert, Martina, Henkes, Elina, Duyster, Justus, Finke, Jürgen, Illerhaus, Gerald

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T‐cell diversification reflects antigen selection in the blood of patients on immune checkpoint inhibition and may be exploited as liquid biopsy biomarker by Akyüz, Nuray, Brandt, Anna, Stein, Alexander, Schliffke, Simon, Mährle, Thorben, Quidde, Julia, Goekkurt, Eray, Loges, Sonja, Haalck, Thomas, Ford, Christopher Thomas, Asemissen, Anne Marie, Thiele, Benjamin, Radloff, Janina, Thenhausen, Toni, Krohn‐Grimberghe, Artus, Bokemeyer, Carsten, Binder, Mascha

“…Cancer immunotherapy with antibodies targeting immune checkpoints, such as programmed cell death protein 1 (PD‐1), shows encouraging results, but reliable…”
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IMMU-55. IMMUNOMODULATORY IL-7 AND IL-12-EXPRESSING MSCs INDUCE LONG-TERM SURVIVAL AND IMMUNITY IN SYNGENEIC INTRACEREBRAL GLIOBLASTOMA MODELS by Mohme, Malte, Maire, Cecile, Geumann, Ulf, Dührsen, Lasse, Schliffke, Simon, Fita, Krystian, Binder, Mascha, Lamszus, Katrin, Guenther, Christine, Westphal, Manfred, Hermann, Felix, Schmidt, Nils Ole

“…Abstract Mesenchymal stem cells (MSCs) show an inherent brain tumor cell tropism that can be exploited for targeted delivery of therapeutic genes to invasive…”
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High-dose chemotherapy and autologous haematopoietic stem-cell transplantation in older, fit patients with primary diffuse large B-cell CNS lymphoma (MARTA): a single-arm, phase 2 trial by Schorb, Elisabeth, Isbell, Lisa Kristina, Kerkhoff, Andrea, Mathas, Stephan, Braulke, Friederike, Egerer, Gerlinde, Röth, Alexander, Schliffke, Simon, Borchmann, Peter, Brunnberg, Uta, Kroschinsky, Frank, Möhle, Robert, Rank, Andreas, Wellnitz, Dominique, Kasenda, Benjamin, Pospiech, Lisa, Wendler, Julia, Scherer, Florian, Deckert, Martina, Henkes, Elina, von Gottberg, Philipp, Gmehlin, Dennis, Backenstraß, Matthias, Jensch, Antje, Burger-Martin, Elvira, Grishina, Olga, Fricker, Heidi, Malenica, Natalie, Orbán, András, Duyster, Justus, Ihorst, Gabriele, Finke, Juergen, Illerhaus, Gerald

“…Available treatments for older patients with primary diffuse large B-cell CNS lymphoma (PCNSL) offer progression-free survival of up to 16 months. We aimed to…”
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T-cell diversification reflects antigen selection in the blood of patients on immune checkpoint inhibition and may be exploited as liquid biopsy biomarker: TCR diversification in checkpoint inhibition by Akyüz, Nuray, Brandt, Anna, Stein, Alexander, Schliffke, Simon, Mährle, Thorben, Quidde, Julia, Goekkurt, Eray, Loges, Sonja, Haalck, Thomas, Ford, Christopher Thomas, Asemissen, Anne Marie, Thiele, Benjamin, Radloff, Janina, Thenhausen, Toni, Krohn-Grimberghe, Artus, Bokemeyer, Carsten, Binder, Mascha

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Opposite Effects of Bruton Tyrosine Kinase (BTK) Inhibitor Therapy with Ibrutinib and FCR Chemo-Immunotherapy on the Normal B Lymphocyte Repertoire in Patients with Chronic Lymphocytic Leukemia by Schliffke, Simon, Sivina, Mariela, Kim, Ekaterina, Thiele, Benjamin, Akyüz, Nuray, Falker-Gieske, Clemens, Thenhausen, Toni, Krohn-Grimberghe, Artus, Bokemeyer, Carsten, Jain, Nitin, Estrov, Zeev, Ferrajoli, Alessandra, Wierda, William G., Keating, Michael J., Burger, Jan A., Binder, Mascha

“…Disease-inherent and treatment-related immune dysfunction remain leading causes for morbidity and mortality in patients with chronic lymphocytic leukemia…”
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