Search Results - "Schliebs, W."

Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites by Dawidowski, M., Emmanouilidis, L., Kalel, V. C., Tripsianes, K., Schorpp, K., Hadian, K., Kaiser, M., Mäser, P., Kolonko, M., Tanghe, S., Rodriguez, A., Schliebs, W., Erdmann, R., Sattler, M., Popowicz, G. M.

“…The parasitic protists of the Trypanosoma genus infect humans and domestic mammals, causing severe mortality and huge economic losses. The most threatening…”
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Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 by Galiani, S., Reglinski, K., Carravilla, P., Barbotin, A., Urbančič, I., Ott, J., Sehr, J., Sezgin, E., Schneider, F., Waithe, D., Hublitz, P., Schliebs, W., Erdmann, R., Eggeling, C.

“…Cellular functions rely on proper actions of organelles such as peroxisomes. These organelles rely on the import of proteins from the cytosol. The peroxisomal…”
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Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway by Einwächter, Henrik, Sowinski, Stefanie, Kunau, Wolf-H, Schliebs, Wolfgang

“…Import of peroxisomal matrix proteins is essential for peroxisome biogenesis. Genetic and biochemical studies using a variety of different model systems have…”
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Active site properties of monomeric triosephosphate isomerase (monoTIM) as deduced from mutational and structural studies by Schliebs, Wolfgang, Thanki, Narmada, Eritja, Ramon, Wierenga, Rik

“…MonoTIM is a stable monomeric variant of the dimeric trypanosomal enzyme triose phosphate isomerase (TIM) with less, but significant, catalytic activity. It is…”
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Peroxisomal matrix protein import: the transient pore model by Erdmann, Ralf, Schliebs, Wolfgang

“…Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal translocation machinery from the well-characterized translocons of…”
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Diffusion and interaction dynamics of the cytosolic peroxisomal import receptor PEX5 by Reglinski, Katharina, Galiani, Silvia, Carravilla, Pablo, Barbotin, Aurelien, Urbancic, Iztok, Sezgin, Erdinc, Schneider, Falk, Waithe, Dominic, Schliebs, Wolfgang, Erdmann, Ralf, Eggeling, Christian

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Protein engineering with monomeric triosephosphate isomerase (monoTIM): the modelling and structure verification of a seven-residue loop by Thanki, N, Zeelen, J P, Mathieu, M, Jaenicke, R, Abagyan, R A, Wierenga, R K, Schliebs, W

“…Protein engineering experiments have been carried out with loop-1 of monomeric triosephosphate isomerase (monoTIM). Loop-1 of monoTIM is disordered in every…”
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An interface point-mutation variant of triosephosphate isomerase is compactly folded and monomeric at low protein concentrations by Borchert, T.V., Zeelen, J.Ph, Schliebs, W., Callens, M., Minke, W., Jaenicke, R., Wierenga, R.K.

“…Wild-type trypanosomal triosephosphate isomerase (wtTIM) is a very tight dimer. The interface residue His-47 of wtTIM has been mutated into an asparagine…”
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Sleeping sickness: PEX and drugs by Schliebs, Wolfgang

“…Finding new ways in the treatment of fatal parasitic diseases like the human sleeping sickness is a major challenge of biomedical research. The growing body of…”
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Functional Similarity between the Peroxisomal PTS2 Receptor Binding Protein Pex18p and the N-Terminal Half of the PTS1 Receptor Pex5p by Schäfer, Antje, Kerssen, Daniela, Veenhuis, Marten, Kunau, Wolf-H., Schliebs, Wolfgang

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Peroxisome Membrane Biogenesis: The Stage Is Set by Schliebs, Wolfgang, Kunau, Wolf-H.

“…Pex3p and Pex19p are key players in the post-translational import of peroxisomal membrane proteins. New data suggest that these peroxins act in tandem, Pex19p…”
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Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14 by Schliebs, W, Saidowsky, J, Agianian, B, Dodt, G, Herberg, F W, Kunau, W H

“…Import of matrix proteins into peroxisomes requires two targeting signal-specific import receptors, Pex5p and Pex7p, and their binding partners at the…”
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The Di-aromatic Pentapeptide Repeats of the Human Peroxisome Import Receptor PEX5 Are Separate High Affinity Binding Sites for the Peroxisomal Membrane Protein PEX14 by Saidowsky, Jürgen, Dodt, Gabriele, Kirchberg, Kristina, Wegner, Albrecht, Nastainczyk, Wolfgang, Kunau, Wolf-H., Schliebs, Wolfgang

“…PEX5 functions as a mobile import receptor for peroxisomal matrix proteins with a peroxisomal targeting signal 1 (PTS1). A critical step within the PTS1-import…”
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Yeast Pex14p Possesses Two Functionally Distinct Pex5p and One Pex7p Binding Sites by Niederhoff, Karsten, Meindl-Beinker, Nadja M., Kerssen, Daniela, Perband, Uta, Schäfer, Antje, Schliebs, Wolfgang, Kunau, Wolf-H.

“…Current evidence favors a cycling receptor model for the import of peroxisomal matrix proteins. The yeast Pex14 protein together with Pex13p and Pex17p form…”
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Pex5p, the Peroxisomal Cycling Receptor, Is a Monomeric Non-globular Protein by Costa-Rodrigues, João, Carvalho, Andreia F., Fransen, Marc, Hambruch, Eva, Schliebs, Wolfgang, Sá-Miranda, Clara, Azevedo, Jorge E.

“…In mammals, targeting of newly synthesized peroxisomal matrix proteins to the organelle requires Pex5p, the peroxisomal cycling receptor. Pex5p is a…”
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A monoclonal antibody for in vivo detection of peroxisome-associated PTS1 receptor by Cizmowski, Christian, Jung, Martin, Erdmann, Ralf, Schliebs, Wolfgang

“…PEX5 is a key protein of the peroxisomal protein import machinery. This cycling receptor binds newly synthesized proteins with a peroxisomal targeting signal…”
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Mammalian Pex14p: membrane topology and characterisation of the Pex14p–Pex14p interaction by Oliveira, Márcia E.M, Reguenga, Carlos, Gouveia, Alexandra M.M, Guimarães, Carla P, Schliebs, Wolfgang, Kunau, Wolf-H, Silva, Manuel T, Sá-Miranda, Clara, Azevedo, Jorge E

“…Peroxisomal biogenesis is a complex process requiring the action of numerous peroxins. One central component of this machinery is Pex14p, an intrinsic…”
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A Double Mutation at the Tip of the Dimer Interface Loop of Triosephosphate Isomerase Generates Active Monomers with Reduced Stability by Schliebs, Wolfgang, Thanki, Narmada, Jaenicke, Rainer, Wierenga, Rik K

“…Triosephosphate isomerase (TIM) is a very stable dimer. In order to understand better the importance of dimerization for stability and catalytic activity, we…”
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Evolutionary Conservation of a Microbody Targeting Signal That Targets Proteins to Peroxisomes, Glyoxysomes, and Glycosomes by Keller, Gilbert-André, Krisans, Skaidrite, Gould, Stephen J., Sommer, Jürg M., Wang, Ching C., Schliebs, Wolfgang, Kunau, Wolfgang, Brody, Stuart, Subramani, Suresh

“…Peroxisomes, glyoxysomes, glycosomes, and hydrogenosomes have each been classified as microbodies, i.e., subcellular organelles with an electron-dense matrix…”
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Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8 by Borchert, T V, Kishan, K V, Zeelen, J P, Schliebs, W, Thanki, N, Abagyan, R, Jaenicke, R, Wierenga, R K

“…Wild-type triosephosphate isomerase (TIM) is a very stable dimeric enzyme. This dimer can be converted into a stable monomeric protein (monoTIM) by replacing…”
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