Search Results - "Schlicker, Lisa"

Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals by Barayeu, Uladzimir, Schilling, Danny, Eid, Mohammad, Xavier da Silva, Thamara Nishida, Schlicker, Lisa, Mitreska, Nikolina, Zapp, Christopher, Gräter, Frauke, Miller, Aubry K., Kappl, Reinhard, Schulze, Almut, Friedmann Angeli, José Pedro, Dick, Tobias P.

“…Ferroptosis is a type of cell death caused by radical-driven lipid peroxidation, leading to membrane damage and rupture. Here we show that enzymatically…”
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LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma by Alborzinia, Hamed, Chen, Zhiyi, Yildiz, Umut, Freitas, Florencio Porto, Vogel, Felix C E, Varga, Julianna Patricia, Batani, Jasmin, Bartenhagen, Christoph, Schmitz, Werner, Büchel, Gabriele, Michalke, Bernhard, Zheng, Jashuo, Meierjohann, Svenja, Girardi, Enrico, Espinet, Elisa, Flórez, Andrés F, dos Santos, Ancely Ferreira, Aroua, Nesrine, Cheytan, Tasneem, Haenlin, Julie, Schlicker, Lisa, Xavier da Silva, Thamara N, Przybylla, Adriana, Zeisberger, Petra, Superti‐Furga, Giulio, Eilers, Martin, Conrad, Marcus, Fabiano, Marietta, Schweizer, Ulrich, Fischer, Matthias, Schulze, Almut, Trumpp, Andreas, Friedmann Angeli, José Pedro

“…Ferroptosis has emerged as an attractive strategy in cancer therapy. Understanding the operational networks regulating ferroptosis may unravel vulnerabilities…”
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c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis by Vollmuth, Nadine, Schlicker, Lisa, Guo, Yongxia, Hovhannisyan, Pargev, Janaki-Raman, Sudha, Kurmasheva, Naziia, Schmitz, Werner, Schulze, Almut, Stelzner, Kathrin, Rajeeve, Karthika, Rudel, Thomas

“…Chlamydia trachomatis (Ctr) can persist over extended times within their host cell and thereby establish chronic infections. One of the major inducers of…”
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Formate promotes invasion and metastasis in reliance on lipid metabolism by Delbrouck, Catherine, Kiweler, Nicole, Chen, Oleg, Pozdeev, Vitaly I., Haase, Lara, Neises, Laura, Oudin, Anaïs, Fouquier d’Hérouël, Aymeric, Shen, Ruolin, Schlicker, Lisa, Halder, Rashi, Lesur, Antoine, Schuster, Anne, Lorenz, Nadja I., Jaeger, Christian, Feucherolles, Maureen, Frache, Gilles, Szpakowska, Martyna, Chevigne, Andy, Ronellenfitsch, Michael W., Moussay, Etienne, Piraud, Marie, Skupin, Alexander, Schulze, Almut, Niclou, Simone P., Letellier, Elisabeth, Meiser, Johannes

“…Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds…”
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Plasma Metabolome Signature Indicative of BRCA1 Germline Status Independent of Cancer Incidence by Penkert, Judith, Märtens, Andre, Seifert, Martin, Auber, Bernd, Derlin, Katja, Hille-Betz, Ursula, Hörmann, Philipp, Klopp, Norman, Prokein, Jana, Schlicker, Lisa, Wacker, Frank, Wallaschek, Hannah, Schlegelberger, Brigitte, Hiller, Karsten, Ripperger, Tim, Illig, Thomas

“…Individuals carrying a pathogenic germline variant in the breast cancer predisposition gene (g +) are prone to developing breast cancer. Apart from its…”
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A multidimensional atlas of human glioblastoma-like organoids reveals highly coordinated molecular networks and effective drugs by Wang, Changwen, Sun, Meng, Shao, Chunxuan, Schlicker, Lisa, Zhuo, Yue, Harim, Yassin, Peng, Tianping, Tian, Weili, Stöffler, Nadja, Schneider, Martin, Helm, Dominic, Chu, Youjun, Fu, Beibei, Jin, Xiaoliang, Mallm, Jan-Philipp, Mall, Moritz, Wu, Yonghe, Schulze, Almut, Liu, Hai-Kun

“…Recent advances in the genomics of glioblastoma (GBM) led to the introduction of molecular neuropathology but failed to translate into treatment improvement…”
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Systemic Lactate Acts as a Metabolic Buffer in Humans and Prevents Nutrient Overflow in the Postprandial Phase by Schlicker, Lisa, Zhao, Gang, Dudek, Christian-Alexander, Boers, Hanny M, Meyer-Hermann, Michael, Jacobs, Doris M, Hiller, Karsten

“…On an organismal level, metabolism needs to react in a well-orchestrated manner to metabolic challenges such as nutrient uptake. Key metabolic hubs in human…”
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Postprandial Metabolic Effects of Fiber Mixes Revealed by in vivo Stable Isotope Labeling in Humans by Schlicker, Lisa, Boers, Hanny M, Dudek, Christian-Alexander, Zhao, Gang, Barua, Arnab, Trezzi, Jean-Pierre, Meyer-Hermann, Michael, Jacobs, Doris M, Hiller, Karsten

“…Food supplementation with a fiber mix of guar gum and chickpea flour represents a promising approach to reduce the risk of type 2 diabetes mellitus (T2DM) by…”
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CaMKII regulates cardiac metabolic substrate switching during heart failure by Saadatmand, Alireza, Pepin, Mark, Haberkorn, Uwe, Okun, Jürgen, Schlicker, Lisa, Schulze, Almut, Backs, Johannes

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Non-Targeted Mass Isotopolome Analysis Using Stable Isotope Patterns to Identify Metabolic Changes by Dudek, Christian-Alexander, Schlicker, Lisa, Hiller, Karsten

“…Gas chromatography coupled with mass spectrometry can provide an extensive overview of the metabolic state of a biological system. Analysis of raw mass…”
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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function by Kurniawan, Henry, Franchina, Davide G., Guerra, Luana, Bonetti, Lynn, - Baguet, Leticia Soriano, Grusdat, Melanie, Schlicker, Lisa, Hunewald, Oliver, Dostert, Catherine, Merz, Myriam P., Binsfeld, Carole, Duncan, Gordon S., Farinelle, Sophie, Nonnenmacher, Yannic, Haight, Jillian, Das Gupta, Dennis, Ewen, Anouk, Taskesen, Rabia, Halder, Rashi, Chen, Ying, Jäger, Christian, Ollert, Markus, Wilmes, Paul, Vasiliou, Vasilis, Harris, Isaac S., Knobbe-Thomsen, Christiane B., Turner, Jonathan D., Mak, Tak W., Lohoff, Michael, Meiser, Johannes, Hiller, Karsten, Brenner, Dirk

“…Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine stimulates glutathione (GSH) synthesis and feeds into the one-carbon…”
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Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity by Lokumcu, Tolga, Iskar, Murat, Schneider, Martin, Helm, Dominic, Klinke, Glynis, Schlicker, Lisa, Bethke, Frederic, Müller, Gabriele, Richter, Karsten, Poschet, Gernot, Phillips, Emma, Goidts, Violaine

“…Glioblastoma is a deadly brain tumor for which there is no cure. The presence of glioblastoma stem-like cells (GSCs) contributes to the heterogeneous nature of…”
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Unexpected roles for ADH1 and SORD in catalyzing the final step of erythritol biosynthesis by Schlicker, Lisa, Szebenyi, Doletha M.E., Ortiz, Semira R., Heinz, Alexander, Hiller, Karsten, Field, Martha S.

“…The low-calorie sweetener erythritol is endogenously produced from glucose through the pentose phosphate pathway in humans. Erythritol is of medical interest…”
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Abstract 3063: Defining oncogene-specific metabolic vulnerabilities in a mouse model of hepatocellular carcinoma by Al-Shami, Kamal, Snaebjornsson, Marteinn, Vogel, Felix, Schlicker, Lisa, Pöller, Phillip, Dauch, Daniel, Schulze, Almut

“…Abstract Despite the continued success of advanced cancer therapies, hepatocellular carcinoma (HCC) represents a substantial challenge to current treatment…”
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USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer by Maier, Carina R., Hartmann, Oliver, Prieto-Garcia, Cristian, Al-Shami, Kamal M., Schlicker, Lisa, Vogel, Felix C. E., Haid, Silke, Klann, Kevin, Buck, Viktoria, Münch, Christian, Schmitz, Werner, Einig, Elias, Krenz, Bastian, Calzado, Marco A., Eilers, Martin, Popov, Nikita, Rosenfeldt, Mathias T., Diefenbacher, Markus E., Schulze, Almut

“…SREBP2 is a master regulator of the mevalonate pathway (MVP), a biosynthetic process that drives the synthesis of dolichol, heme A, ubiquinone and cholesterol…”
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c-Myc plays a key role in IFN-[gamma]-induced persistence of Chlamydia trachomatis by Vollmuth, Nadine, Schlicker, Lisa, Guo, Yongxia, Hovhannisyan, Pargev, Janaki-Raman, Sudha, Kurmasheva, Naziia, Schmitz, Werner, Schulze, Almut, Stelzner, Kathrin, Rajeeve, Karthika, Rudel, Thomas

“…Chlamydia trachomatis (Ctr) can persist over extended times within their host cell and thereby establish chronic infections. One of the major inducers of…”
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p53 deficient breast cancer cells reprogram preadipocytes toward tumor-protective immunomodulatory cells by Hassin, Ori, Sernik, Miriam, Seligman, Adi, Vogel, Felix C E, Wellenstein, Max D, Smollich, Joachim, Halperin, Coral, Pirona, Anna Chiara, Toledano, Liron Nomi, Caballero, Carolina Dehesa, Schlicker, Lisa, Salame, Tomer-Meir, Sarusi Portuguez, Avital, Aylon, Yael, Scherz-Shouval, Ruth, Geiger, Tamar, de Visser, Karin E, Schulze, Almut, Oren, Moshe

“…The gene is mutated in approximately 30% of all breast cancer cases. Adipocytes and preadipocytes, which constitute a substantial fraction of the stroma of…”
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Integrated Metabolomics and Transcriptomics Analysis of Monolayer and Neurospheres from Established Glioblastoma Cell Lines by Peixoto, Joana, Janaki-Raman, Sudha, Schlicker, Lisa, Schmitz, Werner, Walz, Susanne, Winkelkotte, Alina M, Herold-Mende, Christel, Soares, Paula, Schulze, Almut, Lima, Jorge

“…Altered metabolic processes contribute to carcinogenesis by modulating proliferation, survival and differentiation. Tumours are composed of different cell…”
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Spatial single-cell isotope tracing reveals heterogeneity of de novo fatty acid synthesis in cancer by Buglakova, Elena, Ekelöf, Måns, Schwaiger-Haber, Michaela, Schlicker, Lisa, Molenaar, Martijn R., Shahraz, Mohammed, Stuart, Lachlan, Eisenbarth, Andreas, Hilsenstein, Volker, Patti, Gary J., Schulze, Almut, Snaebjornsson, Marteinn T., Alexandrov, Theodore

“…While heterogeneity is a key feature of cancer, understanding metabolic heterogeneity at the single-cell level remains a challenge. Here we present 13…”
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