Search Results - "Schlichting, Rita"

Baseline Toxicity and Volatility Cutoff in Reporter Gene Assays Used for High-Throughput Screening by Escher, Beate I, Glauch, Lisa, König, Maria, Mayer, Philipp, Schlichting, Rita

“…Most studies using high-throughput in vitro cell-based bioassays tested chemicals up to a certain fixed concentration. It would be more appropriate to test up…”
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Maternal paraben exposure triggers childhood overweight development by Leppert, Beate, Strunz, Sandra, Seiwert, Bettina, Schlittenbauer, Linda, Schlichting, Rita, Pfeiffer, Christiane, Röder, Stefan, Bauer, Mario, Borte, Michael, Stangl, Gabriele I., Schöneberg, Torsten, Schulz, Angela, Karkossa, Isabell, Rolle-Kampczyk, Ulrike E., Thürmann, Loreen, von Bergen, Martin, Escher, Beate I., Junge, Kristin M., Reemtsma, Thorsten, Lehmann, Irina, Polte, Tobias

“…Parabens are preservatives widely used in consumer products including cosmetics and food. Whether low-dose paraben exposure may cause adverse health effects…”
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Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes by Schaffert, Alexandra, Karkossa, Isabel, Ueberham, Elke, Schlichting, Rita, Walter, Katharina, Arnold, Josi, Blüher, Matthias, Heiker, John T., Lehmann, Jörg, Wabitsch, Martin, Escher, Beate I., von Bergen, Martin, Schubert, Kristin

“…[Display omitted] •20 plasticizers and their metabolites were screened for PPARγ interaction.•Metabolites of DINCH, DINP, and DPHP most potently induced human…”
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How To Improve the Dosing of Chemicals in High-Throughput in Vitro Mammalian Cell Assays by Fischer, Fabian C, Henneberger, Luise, Schlichting, Rita, Escher, Beate I

“…Controlling the exposure of chemicals in in vitro mammalian cell assays is an important prerequisite for the application of in vitro methods in risk and hazard…”
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Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays by Altenburger, Rolf, Scholze, Martin, Busch, Wibke, Escher, Beate I., Jakobs, Gianina, Krauss, Martin, Krüger, Janet, Neale, Peta A., Ait-Aissa, Selim, Almeida, Ana Catarina, Seiler, Thomas-Benjamin, Brion, François, Hilscherová, Klára, Hollert, Henner, Novák, Jiří, Schlichting, Rita, Serra, Hélène, Shao, Ying, Tindall, Andrew, Tollefsen, Knut Erik, Umbuzeiro, Gisela, Williams, Tim D., Kortenkamp, Andreas

“…Chemicals in the environment occur in mixtures rather than as individual entities. Environmental quality monitoring thus faces the challenge to comprehensively…”
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Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater by Finckh, Saskia, Buchinger, Sebastian, Escher, Beate I., Hollert, Henner, König, Maria, Krauss, Martin, Leekitratanapisan, Warich, Schiwy, Sabrina, Schlichting, Rita, Shuliakevich, Aliaksandra, Brack, Werner

“…[Display omitted] In the present study on endocrine disrupting chemicals (EDCs) in treated wastewater, we used chemical and effect-based tools to analyse 56…”
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Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation by Schaffert, Alexandra, Krieg, Laura, Weiner, Juliane, Schlichting, Rita, Ueberham, Elke, Karkossa, Isabel, Bauer, Mario, Landgraf, Kathrin, Junge, Kristin M., Wabitsch, Martin, Lehmann, Jörg, Escher, Beate I., Zenclussen, Ana C., Körner, Antje, Blüher, Matthias, Heiker, John T., von Bergen, Martin, Schubert, Kristin

“…•BPA and its emerging substitutes BPAF, BPB, BPF, BPS antagonized human PPARγ.•BPA and substitutes decreased adipogenesis of human preadipocytes.•Proteomics…”
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Cellular Uptake Kinetics of Neutral and Charged Chemicals in in Vitro Assays Measured by Fluorescence Microscopy by Fischer, Fabian C, Abele, Cedric, Droge, Steven T. J, Henneberger, Luise, König, Maria, Schlichting, Rita, Scholz, Stefan, Escher, Beate I

“…Cellular uptake kinetics are key for understanding time-dependent chemical exposure in in vitro cell assays. Slow cellular uptake kinetics in relation to the…”
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Phytotoxicity and Innate Immune Responses Induced by Nep1-Like Proteins by Qutob, Dinah, Kemmerling, Birgit, Brunner, Frédéric, Küfner, Isabell, Engelhardt, Stefan, Gust, Andrea A, Luberacki, Borries, Seitz, Hanns Ulrich, Stahl, Dietmar, Rauhut, Thomas, Glawischnig, Erich, Schween, Gabriele, Lacombe, Benoit, Watanabe, Naohide, Lam, Eric, Schlichting, Rita, Scheel, Dierk, Nau, Katja, Dodt, Gabriele, Hubert, David, Gijzen, Mark, Nürnberger, Thorsten

“…We show that oomycete-derived Nep1 (for necrosis and ethylene-inducing peptide1)-like proteins (NLPs) trigger a comprehensive immune response in Arabidopsis…”
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A guidance for the enrichment of micropollutants from wastewater by solid-phase extraction before bioanalytical assessment by Schulze, Tobias, Neale, Peta A., Ahlheim, Jörg, Beckers, Liza-Marie, König, Maria, Krüger, Janet, Petre, Margit, Piotrowska, Aleksandra, Schlichting, Rita, Schmidt, Susanne, Krauss, Martin, Escher, Beate I.

“…Background Wastewater can contain a complex mixture of organic micropollutants, with both chemical analysis and effect-based methods needed to identify…”
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Resilience of Micropollutant and Biological Effect Removal in an Aerated Horizontal Flow Treatment Wetland by Sossalla, Nadine A, Nivala, Jaime, Escher, Beate I, Reemtsma, Thorsten, Schlichting, Rita, van Afferden, Manfred, Müller, Roland A

“…The performance of an aerated horizontal subsurface flow treatment wetland was investigated before, during and after a simulated aeration failure. Conventional…”
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Stress hormone‐independent activation and nuclear translocation of mitogen‐activated protein kinases in Arabidopsis thaliana during ozone exposure by Ahlfors, Reetta, Macioszek, Violetta, Rudd, Jason, Brosché, Mikael, Schlichting, Rita, Scheel, Dierk, Kangasjärvi, Jaakko

“…Summary Changing environmental conditions, atmospheric pollutants and resistance reactions to pathogens cause production of reactive oxygen species (ROS) in…”
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Cytotoxicity Burst? Differentiating Specific from Nonspecific Effects in Tox21 in Vitro Reporter Gene Assays by Escher, Beate I, Henneberger, Luise, König, Maria, Schlichting, Rita, Fischer, Fabian C

“…High-throughput screening of chemicals with reporter gene assays in Tox21 has produced a large database on cytotoxicity and specific modes of action. However,…”
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Inhibition of neurite outgrowth and enhanced effects compared to baseline toxicity in SH-SY5Y cells by Lee, Jungeun, Escher, Beate I., Scholz, Stefan, Schlichting, Rita

“…Early life exposure to environmental chemicals can cause developmental neurotoxicity (DNT). The impairment of key neurodevelopmental processes such as neurite…”
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IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression by Sadik, Ahmed, Somarribas Patterson, Luis F., Öztürk, Selcen, Mohapatra, Soumya R., Panitz, Verena, Secker, Philipp F., Pfänder, Pauline, Loth, Stefanie, Salem, Heba, Prentzell, Mirja Tamara, Berdel, Bianca, Iskar, Murat, Faessler, Erik, Reuter, Friederike, Kirst, Isabelle, Kalter, Verena, Foerster, Kathrin I., Jäger, Evelyn, Guevara, Carina Ramallo, Sobeh, Mansour, Hielscher, Thomas, Poschet, Gernot, Reinhardt, Annekathrin, Hassel, Jessica C., Zapatka, Marc, Hahn, Udo, von Deimling, Andreas, Hopf, Carsten, Schlichting, Rita, Escher, Beate I., Burhenne, Jürgen, Haefeli, Walter E., Ishaque, Naveed, Böhme, Alexander, Schäuble, Sascha, Thedieck, Kathrin, Trump, Saskia, Seiffert, Martina, Opitz, Christiane A.

“…Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context…”
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Critical Membrane Concentration and Mass-Balance Model to Identify Baseline Cytotoxicity of Hydrophobic and Ionizable Organic Chemicals in Mammalian Cell Lines by Lee, Jungeun, Braun, Georg, Henneberger, Luise, König, Maria, Schlichting, Rita, Scholz, Stefan, Escher, Beate I

“…All chemicals can interfere with cellular membranes and this leads to baseline toxicity, which is the minimal toxicity any chemical elicits. The critical…”
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Assessing the Mixture Effects in In Vitro Bioassays of Chemicals Occurring in Small Agricultural Streams during Rain Events by Neale, Peta A, Braun, Georg, Brack, Werner, Carmona, Eric, Gunold, Roman, König, Maria, Krauss, Martin, Liebmann, Liana, Liess, Matthias, Link, Moritz, Schäfer, Ralf B, Schlichting, Rita, Schreiner, Verena C, Schulze, Tobias, Vormeier, Philipp, Weisner, Oliver, Escher, Beate I

“…Rain events may impact the chemical pollution burden in rivers. Forty-four small streams in Germany were profiled during several rain events for the presence…”
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Toxic effects of substituted p-benzoquinones and hydroquinones in in vitro bioassays are altered by reactions with the cell assay medium by Tentscher, Peter R., Escher, Beate I., Schlichting, Rita, König, Maria, Bramaz, Nadine, Schirmer, Kristin, von Gunten, Urs

“…Substituted para-benzoquinones and hydroquinones are ubiquitous transformation products that arise during oxidative water treatment of phenolic precursors, for…”
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Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water by Neale, Peta A., Altenburger, Rolf, Aït-Aïssa, Selim, Brion, François, Busch, Wibke, de Aragão Umbuzeiro, Gisela, Denison, Michael S., Du Pasquier, David, Hilscherová, Klára, Hollert, Henner, Morales, Daniel A., Novák, Jiří, Schlichting, Rita, Seiler, Thomas-Benjamin, Serra, Helene, Shao, Ying, Tindall, Andrew J., Tollefsen, Knut Erik, Williams, Timothy D., Escher, Beate I.

“…Surface waters can contain a diverse range of organic pollutants, including pesticides, pharmaceuticals and industrial compounds. While bioassays have been…”
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Validation of an SH‐SY5Y Cell–Based Acetylcholinesterase Inhibition Assay for Water Quality Assessment by Lee, Jungeun, Huchthausen, Julia, Schlichting, Rita, Scholz, Stefan, Henneberger, Luise, Escher, Beate I.

“…The acetylcholinesterase (AChE) inhibition assay has been frequently applied for environmental monitoring to capture insecticides such as organothiophosphates…”
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