Search Results - "Schlicht, HJ"

Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis by ANDO, K, MORIYAMA, T, GUIDOTTI, L. G, WIRTH, S, SCHREIBER, R. D, SCHLICHT, H. J, SHAO-NAN HUANG, CHISARI, F. V

“…The molecular and cellular mechanisms responsible for cytotoxic T lymphocyte (CTL)-induced immunopathology are not well defined. Using a model in which…”
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HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection by Nayersina, R, Fowler, P, Guilhot, S, Missale, G, Cerny, A, Schlicht, HJ, Vitiello, A, Chesnut, R, Person, JL, Redeker, AG

“…Inasmuch as the hepatitis B virus (HBV) is not directly cytopathic for the infected hepatocyte, it is generally presumed that viral clearance and liver cell…”
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Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus by Köck, J, Theilmann, L, Galle, P, Schlicht, H

“…There have been numerous reports suggesting that human peripheral blood mononuclear cells (PBMCs) can be productively infected with human hepatitis B virus…”
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HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis by MISSALE, G, REDEKER, A, PERSON, J, FOWLER, P, GUILHOT, S, SCHLICHT, H. J, FERRARI, C, CHISARI, F. V

“…We have recently developed the technology to identify and characterize the human histocompatibility leukocyte antigen (HLA) class I-restricted, CD8+ cytotoxic…”
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Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo by Ando, K, Guidotti, LG, Wirth, S, Ishikawa, T, Missale, G, Moriyama, T, Schreiber, RD, Schlicht, HJ, Huang, SN, Chisari, FV

“…Although CD8-positive, class I-restricted CTL play a critical role in viral clearance and immunopathology in many model systems, they have not been shown to…”
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Efficient processing of an antigenic sequence for presentation by MHC class I molecules depends on its neighboring residues in the protein by Del Val, M, Schlicht, H J, Ruppert, T, Reddehase, M J, Koszinowski, U H

“…Processing of endogenously synthesized proteins generates short peptides that are presented by MHC class I molecules to CD8 T lymphocytes. Here it is…”
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HLA Class I-Restricted Human Cytotoxic T Cells Recognize Endogenously Synthesized Hepatitis B Virus Nucleocapsid Antigen by Bertoletti, Antonio, Ferrari, Carlo, Fiaccadori, Franco, Penna, Amalia, Margolskee, Robert, schlicht, Hans J., Fowler, Patricia, Guilhot, Stephane, Chisari, Francis V.

“…Knowledge of the immune effector mechanisms responsible for clearance of hepatitis B virus (HBV)-infected cells has been severely limited by the absence of…”
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Breaking tolerance leads to autoantibody production but not autoimmune liver disease in hepatitis B virus envelope transgenic mice by Wirth, S, Guidotti, LG, Ando, K, Schlicht, HJ, Chisari, FV

“…Hepatitis B virus (HBV) transgenic mice containing the HBV envelope open reading frame under the transcriptional control of the mouse albumin promoter express…”
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Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein by BERTOLETTI, A, CHISARI, F. V, FIACCADORI, F, FERRARI, C, PENNA, A, GUILHOT, S, GALATI, L, MISSALE, G, FOWLER, P, SCHLICHT, H.-J, VIETELLO, A, CHESNUT, R. C

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Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity by Kock, J, Schlicht, H.J

“…Hepadnaviruses contain a relaxed circular DNA genome (RC-DNA) with discontinuities in both strands. Upon infectious entry into a host cell, this genome is…”
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Recombinant Duck Interferon: A New Reagent for Studying the Mode of Interferon Action against Hepatitis B Virus by Schultz, Ursula, Köck, Josef, Schlicht, Hans-Juergen, Staeheli, Peter

“…Although interferon is widely used to treat chronic hepatitis B virus infections, its mode of action against hepadnaviruses is largely unknown, This deficit is…”
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Detection of the human hepatitis B virus X-protein in transgenic mice after radioactive labelling at a newly introduced phosphorylation site by Schmitteckert, Eva Maria, Schlicht, Hans-Jurgen

“…Department of Virology, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany 1 Author for correspondence: Eva Schmitteckert. Present address:…”
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Long-term expression of the hepatitis B virus core-e- and X-proteins does not cause pathologic changes in transgenic mice by Reifenberg, Kurt, Löhler, Jürgen, Pudollek, Hans-Peter, Schmitteckert, Eva, Spindler, Gabriele, Köck, Josef, Schlicht, Hans-Jürgen

“…Background/Aims: Chronic infections with the human hepatitis B virus can result in liver cirrhosis and primary hepatocellular carcinoma. The reasons for these…”
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The Hepatitis B Virus X Protein Transactivates Viral Core Gene Expression In Vivo by Reifenberg, K, Wilts, H, Löhler, J, Nusser, P, Hanano, R, Guidotti, L G, Chisari, F V, Schlicht, H J

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The secretory core protein of human hepatitis B virus is expressed on the cell surface by SCHLICHT, H.-J, SCHALLER, H

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Uptake of duck hepatitis B virus into hepatocytes occurs by endocytosis but does not require passage of the virus through an acidic intracellular compartment by Kock, J. (University of Ulm, Ulm, Germany.), Borst, E.M, Schlicht, H.J

“…The infectious entry pathway of duck hepatitis B virus (DHBV) was investigated with primary duck hepatocytes. Virus uptake was measured by a selective PCR…”
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Synthesis and encapsidation of duck hepatitis B virus reverse transcriptase do not require formation of core-polymerase fusion proteins by Schlicht, H J, Radziwill, G, Schaller, H

“…The expression strategy of the duck hepatitis B virus (DHBV) P gene, which is assumed to encode the viral reverse transcriptase, was investigated by mutational…”
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Differential antigen-processing pathways of the hepatitis B virus e and core proteins by DIEPOLDER, H. M, RIES, G, JUNG, M.-C, SCHLICHT, H.-J, GERLACH, J.-T, GRÜNER, N, CASELMANN, W. H, PAPE, G. R

“…Background & Aims: Hepatitis B e antigen (HBeAg) and hepatitis B core antigen (HBcAg) seem to play different roles in the induction and regulation of the…”
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The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation by SCHLICHT, H. J, SALFIELD, J, SCHALLER, H

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Protection against lethal cytomegalovirus infection by a recombinant vaccine containing a single nonameric T-cell epitope by DEL VAL, M, SCHLICHT, H.-J, VOLKMER, H, MESSERLE, M, REDDEHASE, M. J, KOSZINOWSKI, U. H

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