Search Results - "Schlesner, M"

The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing by Vater, I, Montesinos-Rongen, M, Schlesner, M, Haake, A, Purschke, F, Sprute, R, Mettenmeyer, N, Nazzal, I, Nagel, I, Gutwein, J, Richter, J, Buchhalter, I, Russell, R B, Wiestler, O D, Eils, R, Deckert, M, Siebert, R

“…To decipher the mutational pattern of primary CNS lymphoma (PCNSL), we performed whole-exome sequencing to a median coverage of 103 × followed by mutation…”
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Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing by Zamò, A, Pischimarov, J, Schlesner, M, Rosenstiel, P, Bomben, R, Horn, H, Grieb, T, Nedeva, T, López, C, Haake, A, Richter, J, Trümper, L, Lawerenz, C, Klapper, W, Möller, P, Hummel, M, Lenze, D, Szczepanowski, M, Flossbach, L, Schreder, M, Gattei, V, Ott, G, Siebert, R, Rosenwald, A, Leich, E

“…Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15–~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate…”
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Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma by Wagener, R, Alexandrov, L B, Montesinos-Rongen, M, Schlesner, M, Haake, A, Drexler, H G, Richter, J, Bignell, G R, McDermott, U, Siebert, R

“…Here, primary effusion lymphoma (PEL) is a rare large B-cell neoplasm particularly affecting immunodeficient hosts with an increased incidence in young or…”
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Loss of function of PGAP1 as a cause of severe encephalopathy identified by Whole Exome Sequencing: Lessons of the bioinformatics pipeline by Granzow, M., Paramasivam, N., Hinderhofer, K., Fischer, C., Chotewutmontri, S., Kaufmann, L., Evers, C., Kotzaeridou, U., Rohrschneider, K., Schlesner, M., Sturm, M., Pinkert, S., Eils, R., Bartram, C.R., Bauer, P., Moog, U.

“…We evaluated a multiple consanguineous Turkish family with two children, a boy and a girl, affected by severe encephalopathy, hypotonia, microcephaly and…”
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Mutant KIT as imatinib-sensitive target in metastatic sinonasal carcinoma by Dieter, S.M., Heining, C., Agaimy, A., Huebschmann, D., Bonekamp, D., Hutter, B., Ehrenberg, K.R., Fröhlich, M., Schlesner, M., Scholl, C., Schlemmer, H.-P., Wolf, S., Mavratzas, A., Jung, C.S., Gröschel, S., von Kalle, C., Eils, R., Brors, B., Penzel, R., Kriegsmann, M., Reuss, D.E., Schirmacher, P., Stenzinger, A., Federspil, P.A., Weichert, W., Glimm, H., Fröhling, S.

“…Sinonasal carcinomas (SNCs) comprise various rare tumor types that are characterized by marked histologic diversity and largely unknown molecular profiles, yet…”
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TRANSCRIPTIONAL AND GENOMIC INTRA‐TUMOR HETEROGENEITY DRIVES SUBCLONE SPECIFIC DRUG RESPONSES IN DIFFUSE LARGE B CELL LYMPHOMA by Roider, T., Frauhammer, F., Seufert, J., Bordas, M., Stolarczyk, M., Rabe, S., Malm, J., Bruch, P., Hundemer, M., Rippe, K., Goeppert, B., Seiffert, M., Brors, B., Mechtersheimer, G., Müller‐Tidow, C., Fröhling, S., Schlesner, M., Huber, W., Anders, S., Dietrich, S.

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Genome-Wide DNA Methylation Profiling Reveals Distinct Molecular Subgroups of Juvenile Myelomonocytic Leukemia with Clinical Significance by Lipka, D, Witte, T, Toth, R, Yang, J, Baude, A, Wiesenfarth, M, Brocks, D, Mücke, O, Nöllke, P, Assenov, Y, Schlesner, M, Niemeyer, C, Plass, C, Flotho, C

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MUTATIONAL SIGNATURES IN GERMINAL CENTER DERIVED B‐CELL LYMPHOMAS FROM ADULT PATIENTS ANALYZED IN THE ICGC MMML‐SEQ CONSORTIUM by Huebschmann, D., Kleinheinz, K., Wagener, R., Kretzmer, H., Toprak, U.H., Bernhart, S.H., Lopez Gonzales, C., Kreuz, M., Eils, R., Hansmann, M., Hoffmann, S., Hummel, M., Klapper, W., Lawerenz, C., Loeffler, M., Möller, P., Richter, J., Rosenstiel, P., Rosenwald, A., Stilgenbauer, S., Weniger, M., Trümper, L., Küppers, R., Schlesner, M., Siebert, R.

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OS06.7.A PLATFORM-AGNOSTIC METHYLATION CLASSIFICATION OF 184 CLASSES OF CNS TUMOURS by Patel, A, Schrimpf, D, Jäger, N, Loose, M, Wick, W, Krieg, S, Schlesner, M, Pfister, S M, von Deimling, A, Jones, D T W, Sill, M, Sahm, F

“…Abstract BACKGROUND The 2021 WHO classification underscores the importance of methylation-based Central Nervous System (CNS) tumour diagnostics. The Heidelberg…”
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Cell segmentation-free inference of cell types from in situ transcriptomics data by Park, Jeongbin, Choi, Wonyl, Tiesmeyer, Sebastian, Long, Brian, Borm, Lars E., Garren, Emma, Nguyen, Thuc Nghi, Tasic, Bosiljka, Codeluppi, Simone, Graf, Tobias, Schlesner, Matthias, Stegle, Oliver, Eils, Roland, Ishaque, Naveed

“…Multiplexed fluorescence in situ hybridization techniques have enabled cell-type identification, linking transcriptional heterogeneity with spatial…”
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P18.04.B SINGLE CELL TRANSCRIPTOMIC ANALYSIS IDENTIFIES DISTINCT INTRATUMORAL SUBCLONES IN MENINGIOMA by Blume, C, Tang, Y, Dogan, H, Ritter, M, Dentro, S, von Deimling, A, Gerstung, M, Schlesner, M, Sahm, F, Maas, S L N

“…Abstract BACKGROUND Meningiomas arise from the leptomeninges of the brain and spinal cord. Despite being the most common intracranial tumor in adults, risk…”
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1936P Targeted therapy of desmoplastic small round cell tumor guided by multilayered molecular profiling by Renner, M., Oleś, M., Paramasivam, N., Schneider, A., Heilig, C.E., Modugno, C., Herremans, C., Mock, A., Lipka, D., Bauer, S., Kindler, T., Brandts, C.H., Keilholz, U., Boerries, M., Kuster, B., Hübschmann, D., Schlesner, M., Glimm, H., Schlenk, R.F., Fröhling, S.

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NONCODING RNAs IN BURKITT LYMPHOMA by López, C., Kretzmer, H., Chteinberg, E., Bernhart, S.H., Glaser, S., Patil, P., Ammerpohl, O., Burkhardt, B., Schlesner, M., Hoffmann, S., Siebert, R.

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003 - NONCODING RNAs IN BURKITT LYMPHOMA by López, C., Kretzmer, H., Chteinberg, E., Bernhart, S.H., Glaser, S., Patil, P., Ammerpohl, O., Burkhardt, B., Schlesner, M., Hoffmann, S., Siebert, R.

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OS12.7.A Characterization of intra-tumoral heterogeneity and differential immune activation during malignant progression of meningiomas on single cell level by Blume, C, Dogan, H, Schweizer, L, Wick, W, Weller, M, Mann, M, Kalamarides, M, von Deimling, A, Schlesner, M, Sahm, F

“…Abstract BACKGROUND As the most common intracranial tumor, meningiomas have caused increasing interest in the field of medical research. Based on their…”
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PL02.2.A RAPID, COMPREHENSIVE REPORTING OF MOLECULAR DIAGNOSTICS WITH RAPID-CNS2: A PROSPECTIVE VALIDATION COHORT by Patel, A, Hinz, F, Dogan, H, Payne, A, Göbel, K, Schrimpf, D, Ritter, M, Krause, E, Pfeifer, L, Krech, M, Blume, C, Stichel, D, Goidts, V, Schweizer, L, Unterberg, A, Wick, W, Pfister, S, Sill, M, Loose, M, von Deimling, A, Jones, D T W, Schlesner, M, Sahm, F

“…Abstract BACKGROUND The WHO classification of CNS tumours 2021 recommends reporting a wide range of molecular alterations for WHO-compatible diagnoses…”
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DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease by Czeh, Melinda, Stäble, Sina, Krämer, Stephen, Tepe, Lena, Talyan, Sweta, Carrelha, Joana, Meng, Yiran, Heitplatz, Barbara, Schwabenland, Marius, Milsom, Michael D, Plass, Christoph, Prinz, Marco, Schlesner, Matthias, Andrade-Navarro, Miguel A, Nerlov, Claus, Jacobsen, Sten Eirik W, Lipka, Daniel B, Rosenbauer, Frank

“…Dendritic cells (DCs) are heterogeneous immune regulators involved in autoimmune diseases. Epigenomic mechanisms orchestrating DC development and DC subset…”
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JS08.6.A A connectivity signature for glioblastoma by Hoffmann, D C, Hai, L, Wagener, R, Mandelbaum, H, Xie, R, Hausmann, D, Dominguez Azorín, D, Weil, S, Sievers, P, Cebulla, G, Ito, J, Warnken, U, Venkataramani, V, Ernst, K, Reibold, D, Will, R, Suvà, M L, Herold-Mende, C, Sahm, F, Winkler, F, Schlesner, M, Wick, W, Kessler, T

“…Abstract Background Tumor cell extensions called tumor microtubes (TMs) in glioma resemble neurites during neurodevelopment and connect glioma cells to a…”
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Author Correction: Cell segmentation-free inference of cell types from in situ transcriptomics data by Park, Jeongbin, Choi, Wonyl, Tiesmeyer, Sebastian, Long, Brian, Borm, Lars E., Garren, Emma, Nguyen, Thuc Nghi, Tasic, Bosiljka, Codeluppi, Simone, Graf, Tobias, Schlesner, Matthias, Stegle, Oliver, Eils, Roland, Ishaque, Naveed

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34 - Genome-Wide DNA Methylation Profiling Reveals Distinct Molecular Subgroups of Juvenile Myelomonocytic Leukemia with Clinical Significance by Lipka, D., Witte, T., Toth, R., Yang, J., Baude, A., Wiesenfarth, M., Brocks, D., Mücke, O., Nöllke, P., Assenov, Y., Schlesner, M., Niemeyer, C., Plass, C., Flotho, C.

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