Search Results - "Schleimer, Michael"

Single-Ascending-Dose Pharmacokinetics and Safety of the Novel Broad-Spectrum Antifungal Triazole BAL4815 after Intravenous Infusions (50, 100, and 200 Milligrams) and Oral Administrations (100, 200, and 400 Milligrams) of Its Prodrug, BAL8557, in Healthy Volunteers by SCHMITT-HOFFMANN, Anne, ROOS, Brigitte, HEEP, Markus, SCHLEIMER, Michael, WEIDEKAMM, Erhard, BROWN, Tom, ROEHRLE, Michael, BEGLINGER, Christoph

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Multiple-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers by SCHMITT-HOLFMANN, Anne, NYMAN, Lars, ROOS, Brigitte, SCHLEIMER, Michael, SAUER, Jill, NASHED, Norman, BROWN, Thomas, MAN, Anthony, WEIDEKAMM, Erhard

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Single-Dose Pharmacokinetics and Safety of a Novel Broad-Spectrum Cephalosporin (BAL5788) in Healthy Volunteers by SCHMITT-HOFFMANN, Anne, ROOS, Brigitte, SCHLEIMER, Michael, SAUER, Jill, MAN, Anthony, NASHED, Norman, BROWN, Thomas, PEREZ, Antonio, WEIDEKAMM, Erhard, KOVACS, Péter

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Potential inhibitory effects of formulation ingredients on intestinal cytochrome P450 by Mountfield, Richard J., Senepin, Sandrine, Schleimer, Michael, Walter, Isabelle, Bittner, Beate

“…The use of common formulation ingredients (categorized into six groups) for preclinical animal studies has been assessed with respect to cytochrome P450 (CYP)…”
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Enantiomer Separation by Capillary SFC and GC on Chirasil-Nickel: Observation of Unusual Peak Broadening Phenomena by Schleimer, Michael, Fluck, Markus, Schurig, Volker

“…Immobilized chirasil-nickel was used for the separation of enantiomers by capillary supercritical fluid chromatography (SFC) and gas chromatography. It is…”
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Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-(14C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs by Grunwald, Helge, Hargreaves, Patrick, Gebhardt, Klaus, Klauer, Dominique, Serafyn, Arnaud, Schmitt-Hoffmann, Anne, Schleimer, Michael, Schlotterbeck, Goetz, Wind, Mathias

“…A systematic comparison between two labeling approaches for the investigation of the in vitro metabolic pattern of pharmaceutical drugs was performed by…”
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Investigation of the species-dependent in vitro metabolism of BAL30630 by stable isotope labeling and isotope exchange experiments analyzed by capillary liquid chromatography coupled to mass spectrometry by Wind, Mathias, Grunwald, Helge, Gebhardt, Klaus, Illig, Klaus, Spickermann, Jochen, Nuoffer, Claude, Roussel, Patrick, Klauer, Dominique, Fullhardt, Pascal, Schmitt-Hoffmann, Anne, Schleimer, Michael

“…The in vitro metabolic profile of BAL30630, an antifungal piperazine propanol derivative, which inhibits the 1,3-beta- d-glucansynthase, was investigated by…”
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Performance and reliability of splitless microliter gradient pumps in a metabolic stability study using cytochrome P450/3A4 and capillary liquid chromatography–mass spectrometry by Kuhn, Fabian, Oehme, Michael, Schleimer, Michael

“…The performance of two commercially available capillary LC pumps (MicroPro (Eldex, USA), Evolution 200 (ProLab, Switzerland)) generating really splitless…”
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Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-((14)C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs by Grunwald, Helge, Hargreaves, Patrick, Gebhardt, Klaus, Klauer, Dominique, Serafyn, Arnaud, Schmitt-Hoffmann, Anne, Schleimer, Michael, Schlotterbeck, Goetz, Wind, Mathias

“…A systematic comparison between two labeling approaches for the investigation of the in vitro metabolic pattern of pharmaceutical drugs was performed by…”
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Elucidation of the in vitro metabolic profile of stable isotope labeled BAL19403 by accurate mass capillary liquid chromatography/quadrupole time-of-flight mass spectrometry and isotope exchange by Wind, Mathias, Gebhardt, Klaus, Grunwald, Helge, Spickermann, Jochen, Donzelli, Massimiliano, Kellenberger, Laurenz, Muller, Marc, Fullhardt, Pascal, Schmitt-Hoffmann, Anne, Schleimer, Michael

“…The in vitro metabolic pattern of BAL19403, a novel macrolide antibiotic, was investigated by capillary liquid chromatography/quadrupole time‐of‐flight mass…”
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Investigation of low-abundant in vitro metabolites of stable isotope-labelled BAL4815 by accurate mass capillary-LC-ESI-qTof-MS and MS/MS by Wind, Mathias, Spickermann, Jochen, Schleimer, Michael, Donzelli, Massimiliano, Gebhardt, Klaus, Sturm-Haurany, Rima, Klauer, Dominique, Fullhardt, Pascal, Schmitt-Hoffmann, Anne

“…The metabolic profile of BAL4815, an antifungal azole drug, was determined using in vitro rat hepatocyte incubations and subsequent analysis by capillary…”
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The effect of tolcapone on the pharmacokinetics of benserazide by Jorga, Karin M., Larsen, Jan P., Beiske, Antonie, Schleimer, Michael, Fotteler, Bärbel, Schmitt, Monique, Moe, Brit

“…This study investigated the potential interaction between tolcapone, a catechol‐O‐methyltransferase (COMT) inhibitor, and the decarboxylase inhibitor,…”
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Preformulation approaches to improve the oral bioavailability of two novel piperidine renin inhibitors in dog by BITTNER, Beate, CHOU, Ruby, SCHLEIMER, Michael, MORGENROTH, Brita, ZELL, Manfred, LAVE, Thierry

“…Different experimental formulations based on aqueous and oily systems, water miscible solvents, and solid dispersions were investigated for their potential to…”
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