Search Results - "Schleif, W. A"

L-735,524: An Orally Bioavailable Human Immunodeficiency Virus Type 1 Protease Inhibitor by Vacca, J. P., Dorsey, B. D., Schleif, W. A., Levin, R. B., McDaniel, S. L., Darke, P. L., Zugay, J., Quintero, J. C., Blahy, O. M., Roth, E., Sardana, V. V., Schlabach, A. J., Graham, P. I., Condra, J. H., Gotlib, L., Holloway, M. K., Lin, J., I.-W. Chen, Vastag, K., Ostovic, D., Anderson, P. S., Emini, E. A., Huff, J. R.

“…To date, numerous inhibitors of the human immunodeficiency virus type 1 protease have been reported, but few have been studied extensively in humans, primarily…”
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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors by Condra, Jon H, Schleif, William A, Blahy, Olga M, Gabryelski, Lori J, Graham, Donald J, Quintero, Julio, Rhodes, Audrey, Robbins, Helen L, Roth, Elizabeth, Shivaprakash, Malathi, Titus, Donna, Yang, Tao, Tepplert, Hedy, Squires, Kathleen E, Deutsch, Paul J, Emini, Emilio A

“…Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The…”
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Active Human Immunodeficiency Virus Protease is Required for Viral Infectivity by Kohl, Nancy E., Emini, Emilio A., Schleif, William A., Davis, Lenora J., Heimbach, Jill C., Richard A. F. Dixon, Scolnick, Edward M., Sigal, Irving S.

“…Retroviral proteins are synthesized as polyprotein precursors that undergo proteolytic cleavages to yield the mature viral proteins. The role of the human…”
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Simultaneous vs Sequential Initiation of Therapy With Indinavir, Zidovudine, and Lamivudine for HIV-1 Infection: 100-Week Follow-up by Gulick, Roy M, Mellors, John W, Havlir, Diane, Eron, Joseph J, Gonzalez, Charles, McMahon, Deborah, Jonas, Leslie, Meibohm, Anne, Holder, Daniel, Schleif, William A, Condra, Jon H, Emini, Emilio A, Isaacs, Robin, Chodakewitz, Jeffrey A, Richman, Douglas D

“…CONTEXT.— Combination antiretroviral therapy can markedly suppress human immunodeficiency virus (HIV) replication but the duration of HIV suppression varies…”
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Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor by Condra, J H, Holder, D J, Schleif, W A, Blahy, O M, Danovich, R M, Gabryelski, L J, Graham, D J, Laird, D, Quintero, J C, Rhodes, A, Robbins, H L, Roth, E, Shivaprakash, M, Yang, T, Chodakewitz, J A, Deutsch, P J, Leavitt, R Y, Massari, F E, Mellors, J W, Squires, K E, Steigbigel, R T, Teppler, H, Emini, E A

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L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase by YOUNG, S. D, BRITCHER, S. F, PETTIBONE, D. J, O'BRIEN, J. A, BALL, R. G, BALANI, S. K, LIN, J. H, I-WU CHEN, SCHLEIF, W. A, SARDANA, V. V, LONG, W. J, BYRNES, V. W, TRAN, L. O, EMINI, E. A, PAYNE, L. S, LUMMA, W. C, LYLE, T. A, HUFF, J. R, ANDERSON, P. S, OLSEN, D. B, CARROLL, S. S

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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors by NUNBERG, J. H, SCHLEIF, W. A, BOOTS, E. J, O'BRIEN, J. A, QUINTERO, J. C, HOFFMAN, J. M, EMINI, E. A, GOLDMAN, M. E

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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells by LAFEMINA, R. L, SCHNEIDER, C. L, ROBBINS, H. L, CALLAHAN, P. L, LEGROW, K, ROTH, E, SCHLEIF, W. A, EMINI, E. A

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Pyridinone Derivatives: Specific Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors with Antiviral Activity by Goldman, Mark E., Nunberg, Jack H., O'Brien, Julie A., Quintero, Julio C., Schleif, William A., Freund, Kurt F., Gaul, S. Lee, Saari, Walfred S., Wai, John S., Hoffman, Jacob M., Anderson, Paul S., Hupe, Donald J., Emini, Emilio A., Stern, Andrew M.

“…Derivatives of pyridinones were found to inhibit human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) activity and prevent the spread of…”
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L-735,524 : the design of a potent and orally bioavailable HIV protease inhibitor by DORSEY, B. D, LEVIN, R. B, LIN, J. H, CHEN, I.-W, HOLLOWAY, M. K, FITZGERALD, P. M. D, AXEL, M. G, OSTOVIC, D, ANDERSON, P. S, HUFF, J. R, MCDANIEL, S. L, VACCA, J. P, GUARE, J. P, DARKE, P. L, ZUGAY, J. A, EMINI, E. A, SCHLEIF, W. A, QUINTERO, J. C

“…A series of HIV protease inhibitors possessing a hydroxylaminepentanamide transition state isostere have been developed. Incorporation of a basic amine into…”
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Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody by EMINI, E. A, SCHLEIF, W. A, EICHBERG, J. W, MURTHY, K. K, NUNBERGB, J. H, CONLEY, A. J, EDA, Y, TOKIYOSHI, S, PUTNEY, S. D, MATSUSHITA, S, COBB, K. E, JETT, C. M

“…The acquired immunodeficiency syndrome (AIDS) is the late-stage clinical manifestation of long-term persistent infection with the human immunodeficiency virus…”
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An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease:  Computational Analysis and X-ray Crystal Structure of the Enzyme Complex by Smith, Amos B, Hirschmann, Ralph, Pasternak, Alexander, Yao, Wenquing, Sprengeler, Paul A, Holloway, M. Katharine, Kuo, Lawrence C, Chen, Zhongguo, Darke, Paul L, Schleif, William A

“…We have described several potent inhibitors of the HIV-1 protease, based on the novel 3,5-linked bispyrrolinone scaffold which we developed to mimic the…”
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Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors by BYRNES, V. W, SARDANA, V. V, GRAHAM, D. J, GOTLIB, L, RHODES, A, TITUS, D. L, ROTH, E, BLAHY, O. M, QUINTERO, J. C, STASZEWSKI, S, EMINI, E. A, SCHLEIF, W. A, CONDRA, J. H, WATERBURY, J. A, WOLFGANG, J. A, LONG, W. J, SCHNEIDER, C. L, SCHLABACH, A. J, WOLANSKI, B. S

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The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate by Conley, A J, Kessler, 2nd, J A, Boots, L J, McKenna, P M, Schleif, W A, Emini, E A, Mark, 3rd, G E, Katinger, H, Cobb, E K, Lunceford, S M, Rouse, S R, Murthy, K K

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Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents : X-ray crystal structure assisted design by THOMPSON, W. J, FITZGERALD, P. M. D, SCHWERING, J. E, HOMMICK, C. F, NUNBERG, J, SPRINGER, J. P, HUFF, J. R, HOLLOWAY, M. K, EMINI, E. A, DARKE, P. L, MCKEEVER, B. M, SCHLEIF, W. A, QUINTERO, J. C, ZUGAY, J. A, TUCKER, T. J

“…By tethering of a polar hydrophilic group to the P1 or P1' substituent of a Phe-based hydroxyethylene isostere, the antiviral potency of a series of HIV…”
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L-687,908, a potent hydroxyethylene containing HIV protease inhibitor by Vacca, Joseph P, Guare, J. P, DeSolms, S. J, Sanders, W. M, Giuliani, E. A, Young, S. D, Darke, P. L, Sigal, I. S, Schleif, W. A

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A nonnucleoside reverse transcriptase inhibitor active on human immunodeficiency virus type 1 isolates resistant to related inhibitors by GOLDMAN, M. E, O'BRIEN, J. A, RUFFING, T. L, SCHLEIF, W. A, SARDANA, V. V, BYRNES, V. W, CONDRA, J. H, HOFFMAN, J. M, EMINI, E. A

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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells by Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D

“…Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunedeficiency syndrome (AIDS). The unique nature of the replicative cycle…”
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L-696,229 specifically inhibits human immunodeficiency virus type 1 reverse transcriptase and possesses antiviral activity in vitro by GOLDMAN, M. E, O'BRIEN, J. A, RUFFING, T. L, NUNBERG, J. H, SCHLEIF, W. A, QUINTERO, J. C, SIEGL, P. K. S, HOFFMAN, J. M, SMITH, A. M, EMINI, E. A

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Antibody-mediated in vitro neutralization of human immunodeficiency virus type 1 abolishes infectivity for chimpanzees by EMINI, E. A, NARA, P. L, GERETY, R. J, EICHBERG, J. W, ISCHLEIF, W. A, LEWIS, J.A, DAVIDE, J. P, LEE, D. R, KESSLER, J, CONLEY, S, MATSUSHITA, S, PUTNEY, S. D

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